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Lotus plumule and new application of extractive thereof

A technology for the use of lotus seed heart, applied in the field of bisbenzylisoquinoline-single ether bond alkaloid derivatives or analogs, lotus seed heart alkaloids, to relieve obstructive symptoms, treat seborrheic alopecia, and have clear drug effects Effect

Inactive Publication Date: 2014-12-31
李宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no medicament, health food and food additive for the treatment of benign prostatic hyperplasia, hair loss and acne

Method used

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  • Lotus plumule and new application of extractive thereof
  • Lotus plumule and new application of extractive thereof
  • Lotus plumule and new application of extractive thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 total alkaloids of Lianxin of the present invention

[0038]Take the lotus heart, crush it, add 2 to 6 times of water, decoct 3 times for 0.5 to 2 hours each time, combine the filtrate, reflux to concentrate, filter, add 2 to 8 times of ethanol to make the ethanol concentration in the water extraction solution reach 50 to 60%. Let it stand for 12-24 hours, filter, and recover the ethanol from the filtrate under reduced pressure, concentrate to a relative density of 1.20-1.40, dry under reduced pressure to obtain the lotus heart extract, which is the total alkaloids of lotus heart. The content is determined by ultraviolet spectrophotometry, and the result: the weight percentage of the total alkaloids is 70%, and the weight percentage is 30% based on liensinine.

Embodiment 2

[0039] The preparation of embodiment 2 Lianxin total alkaloids of the present invention

[0040] Take the lotus heart, crush it, use 2-5 times the amount of 70-85% ethanol to reflux extract 2-4 times, each time reflux extraction for 0.5-1.5h, filter the combined filtrate, recover ethanol under reduced pressure, and the relative density of concentration is 1.01-1.10 of concentrate. Adjust the pH of the concentrated solution to 2.0-4.0 with sulfuric acid, stand still, centrifuge, adjust the pH of the centrifuged solution to 8-10 with 10-20% ammonia alkalinity, stand still, filter to collect the precipitate, add ethanol to heat to dissolve, stand still, filter, The filtrate is recovered under reduced pressure to ethanol to the maximum, concentrated to a relative density of 1.20-1.40, and dried under reduced pressure to obtain the lotus heart extract, which is the total alkaloids of lotus heart. The total alkaloid content is 50%, accounting for 10% in terms of liensinine. The co...

Embodiment 3

[0041] The preparation of embodiment 3 Lianxin total alkaloids of the present invention

[0042] Take the lotus heart, crush it, put it into a percolator, add 2-6‰HCl to impregnate and expand for 24-48h, then add new 2-6‰HCl continuously, let it permeate through the medicinal material from top to bottom, from the lower part of the percolator Flow out and collect the leachate, combine all the filtrates, alkalinize with 10-20% ammonia to a pH of 8-10, filter to obtain a precipitate, and dry under reduced pressure to obtain the total alkaloids of lotus heart, the total alkaloid content is 30%, calculated as liensinine 15%. The content was determined by UV spectrophotometry.

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Abstract

The invention provides a new application of lotus plumule, in particular to the application of the lotus plumule, lotus plumule total alkaloid, bisbenzylisoquinoline-(7-0-11')-monoether key alkaloid derivant or analogue in preparing a drug or health care food of 5 alpha-reductase inhibitor. The invention also provides a 5 alpha-reductase inhibitor. The lotus plumule of the invention serves as the 5 alpha-reductase inhibitor and can serve as drug, health care food or food additive. The lotus plumule and the active ingredients thereof of the invention are used for inhibiting 5 alpha-reductase, can reduce prostate gland, can quickly remove the obstruction symptom of benign prostatic hyperplasia, can treat seborrheic alopecia and acne, has specific potency and controllable quality, is safe and provides a new option for clinic.

Description

technical field [0001] The invention provides lotus seed heart and its extract, specifically, lotus seed heart and its extract, lotus seed heart alkaloid, bisbenzylisoquinoline-(7-0-11')-mono-ether bond alkaloid derivative or similar uses. It belongs to the field of medicine. Background technique [0002] Lotus seed heart (PLUMULA NELUMBINIS), also known as lotus heart, is the green and tender germ in the mature seeds of the perennial aquatic herb lotus of the water lily family Nelumbonucifera Gaertn. "Chinese Pharmacopoeia" 2005 edition one recorded, has the functions of clearing the heart and calming the nerves, communicating the heart and kidney, astringent essence and hemostasis. According to reports, lotus seeds mainly contain alkaloids such as liensinine, neferine, isoliensinine and flavonoids such as luteolin and rutin. The medicinal effects of lotus seed heart are mainly antihypertensive and antiarrhythmic effects. [0003] Li Juan, et al., Research Progress on t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/62A61K31/4725A61K9/00A23L1/29A23L1/30A61P13/08A61P17/14A61P17/10A61K131/00A23L33/105
Inventor 李宏
Owner 李宏
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