Garlic oil enteric pellet capsule and preparation method thereof

Abstract

The invention relates to the field of antibacterial agent, in particular to a garlic oil enteric pellet capsule and a preparation method thereof. Wherein the garlic oil pellet capsule is composed of a coated pellets and a coating layer, the coated pellets comprises pharmaceutically active ingredients of garlic oil and coated pellet minor ingredient; wherein the coated pellet minor ingredient comprises pellet core, bonding agent, absorbing agent, disintegrating agent, antioxygen agent and antiplastering aid while the coating layer comprises an enteric coating and an isolated layer; the coated pellet comprises the following components according to weight percentage: 5-40% of garlic oil, 10-60% of pellet core, 2-10% of binding agent, 20-50% of absorbing agent, 0.5-5% of antioxygen agent, 0.5-10% of disintegrating agent and 2-20% of antiplastering aid.Compared with the existing allicin dosage form, the garlic oil enteric pellet capsule of the invention enjoys more advanced dosage form, thus ensuring effectiveness and stability of the capsule and high bioavailability; in addition, with the enteric pellet capsule of the invention, harm done to gastric mucosa as the capsule is dissolved inside the stomach is avoided and the allicin is not damaged by gastric acid so that drug effect of the capsule is not affected.

Description

technical field [0001] The invention relates to the field of antibacterial drug preparations, in particular to a garlic oil enteric-coated pellet capsule and a preparation method thereof. Background technique [0002] Allicin (Allicin), also known as allicin, chemical name diallyl trisulfide (CH2=CH2CH22S2S2S2CH22CH=CH2), is a volatile oily substance extracted from the spherical bulb of garlic, and is the main active ingredient of garlic. In addition to garlic's traditional antibacterial, antiviral, and antiprotozoal effects, allicin has been proven by modern medicine to have antitumor, lower blood lipids, and improve body immunity. It is known as "natural broad-spectrum antibiotics". Pure allicin The bactericidal effect of garlic is 100 times that of penicillin. In today's situation where antibiotics are abused and antibacterial properties are continuously enhanced, garlic oil is considered to be an ideal and safe alternative. In recent years, scholars at home and abroad h...

AI Technical Summary

Problems solved by technology

[0003] 1. Ordinary tablets, capsules, and soft capsules are disintegrated in the stomach, and the main drug has poor stability and easy degradation under acidic conditions, making it difficult to play its due role;

[0004] 2. Although enteric-coated tablets can avoid gastric acid damage, the retention time in the stomach is called micro-pills, and the release in the intestine is not as uniform as micro-pills; enteric-coated capsules are easy to open in the stomach, and thus partially destroyed

[0005] 3. Enteric-coated capsules may also be broken due to food extrusion. Even if they are opened in the intestine, the drug distribution concentration is much more concentrated than that of micropills, which is not conducive to the absorption of drugs, so there is no drug effect of micropill preparations at the same dose

[0006] Publication No. CN101006994 Chinese patent application for allicin enteric-coated capsules and its preparation method discloses a kind of allicin enteric-coated capsules and its preparation method, the patent application is to coat garlic oil with β-cyclodextrin, and then Then make granules or micropills, and finally cover the capsule shell to get it. After the micropills of this enteric-coated capsule are dissolved in the intestine, the cost of using β-cyclodextrin and garlic oil is relatively high, and the cost of β-cyclodextrin packaging is relatively high. Poor packaging and compatibility lead to easy degradation of allicin and poor stability

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