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Method for synthesizing lauroyl L-carnitine hydrochloride

A technology of lauroyl-L-carnitine and hydrochloride, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve problems such as no lauroyl-L-carnitine hydrochloride synthesis report and the like, and achieve a simple method. Easy operation, high yield and cost saving effect

Inactive Publication Date: 2012-12-12
湖北海力环保科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are no reports on the synthesis of lauroyl L-carnitine hydrochloride at home and abroad

Method used

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  • Method for synthesizing lauroyl L-carnitine hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] like figure 1 Shown, a kind of method of synthetic lauroyl-L-carnitine hydrochloride, it comprises the steps:

[0024] 1). Add 161.2g of weighed acetic acid into a four-necked flask (the capacity of the four-necked flask is 1L), and add 161.2g of L-carnitine under stirring to dissolve. After it is completely dissolved, add 221g of lauroyl chloride; then heat up to 75°C Constant temperature for 5 hours; after the reaction is completed, evaporate acetic acid in a vacuum of -0.09Mpa and a temperature below 80°C, add 600g of acetone when the temperature is lowered to 40°C, stir and disperse for 0.5 hours, cool down to below 5°C (including 5°C) for crystallization, and Insulate at 0-5°C for 2 hours; filter, wash the material with acetone, and suction-filter to obtain the crude product, and dry it under vacuum -0.09Mpa, 80-105°C to obtain 372.7g of the crude product of lauroyl-L-carnitine hydrochloride, with a yield of 98.1% .

[0025] 2). Take 200g of the crude product of ...

Embodiment 2

[0033] A method for synthesizing lauroyl L-carnitine hydrochloride, it comprises the steps:

[0034] 1). Add 200g of weighed acetic acid into a four-necked flask, and add 161.2g of L-carnitine to dissolve under stirring. After it is completely dissolved, add 263g of lauroyl chloride dropwise; then raise the temperature to 70°C for 8 hours; Vacuum -0.09Mpa, temperature below 80°C to evaporate acetic acid to precipitate a large number of crystals, cool down to 40°C, add 600g of acetone, fully stir and disperse for 0.5 hours, cool down to below 5°C to crystallize, and keep warm at 0-5°C for 2 hours; filter , to obtain the crude product by suction filtration, and dried at 80° C. with a vacuum of -0.09Mpa to obtain 374 g of the crude product of lauroyl-L-carnitine hydrochloride, with a yield of 98.4%.

[0035] 2). Take 200g of crude lauroyl-L-carnitine hydrochloride, add it into a reactor filled with 420g of anhydrous methanol and stir to dissolve; raise the temperature to 65°C and...

Embodiment 3

[0037] The charge of lauroyl chloride was 218.76g, and the other implementation steps were the same as in Example 2, with a total yield of 92.5%, and the mass content measured under the same high-efficiency liquid phase conditions as in Example 1 was 99.23%. Optical rotation: -25.3° (c=10, H2O), pH value: 2.5, white crystalline powder.

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Abstract

The invention relates to a method for synthesizing an aminocarboxylic acid class compound, in particular to a method for synthesizing lauroyl L-carnitine hydrochloride, which belongs to the technical field of the preparation of a medicine intermediate and a food additive. The method for synthesizing the lauroyl L-carnitine hydrochloride is characterized by comprising the following steps of: (1) taking L-carnitine as a raw material and acetic acid as a solvent, adding lauroyl chloride, decompressing after heating and reacting, distilling off the acetic acid, adding acetone, stirring, dispersing, cooling, crystallizing, then leaching and drying to obtain a crude product; and (2) heating the obtained crude product by using ethanol or methanol, dissolving, leaching when heating to obtain filtrate, decompressing, distilling, concentrating, distilling off part of the ethanol or the methanol, then cooling, adding the acetone, stirring evenly, cooling, crystallizing, then filtering and dryingto obtain a pure product of the lauroyl L-carnitine hydrochloride. The invention has the characteristics of simple and easy operation, little pollution, short reaction period and low cost and is suitable for the industrial scale-up production, and the yield at least reaches 92 percent.

Description

technical field [0001] The invention relates to a method for synthesizing aminocarboxylic acid compounds, in particular to a method for synthesizing lauroyl-L-carnitine hydrochloride, which belongs to the technical field of preparation of pharmaceutical intermediates and food additives. Background technique [0002] There have been many reports on the efficacy of L-carnitine (L-carnitine, L-carnitine). L-carnitine is an important food nutrition enhancer and has been widely used in the food industry, such as baby milk powder, diet food, athletes Nutritional products and nutritional supplements for middle-aged and elderly people, as well as in the feed processing industry, in addition to medical effects, cardiovascular diseases, liver diseases, kidney diseases, hyperlipidemia, diabetes, neuromuscular diseases, etc. can all be treated by taking L-meat Alkaline series of new products have improved symptoms, and it has been reported that L-carnitine can also improve reproductive ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/22C07C227/18
Inventor 周拥军史铁京刘传红靖志强吴莎莎
Owner 湖北海力环保科技股份有限公司
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