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Medicinal composition containing atractylodes rhizome extractive

A kind of Atractylodes Rhizoma extract, extract technology, applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc.

Inactive Publication Date: 2013-02-27
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] In the various pharmaceutical compositions for treating diabetes in the prior art, although there are three medicinal materials Anemarrhena, Cortex Phellodendron and Atractylodes Rhizome, there is no pharmaceutical composition mainly composed of the three medicinal materials Zhimu, Phellodendron Phellodendron and Atractylodes Rhizoma Atractylodis, let alone The medicinal composition which is composed of the extracts of these three kinds of medicinal materials and the active ingredients is compatible and has significant medicinal effects for the prevention and treatment of diabetes

Method used

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  • Medicinal composition containing atractylodes rhizome extractive
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  • Medicinal composition containing atractylodes rhizome extractive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Embodiment 1 timosaponin A-III, B-II and B-III content determination

[0100] Column: Diamonsil TM C 18 (200mm×4.6mm, 5μm). Column temperature: 25°C, flow rate 1.0ml / min. ELSD detector, drift tube temperature 70°C, atomizing gas flow rate 1.8SPLM. The injection volume is 20 μl.

[0101] Mobile phase A: acetonitrile; mobile phase B: 0.2% formic acid aqueous solution; equilibrated with 30% mobile phase B, 30 minutes linear gradient elution, 90% mobile phase B terminated.

[0102] Accurately weigh 20.0 mg each of timosaponin A-III, B-II and B-III standard substances, put them in a 10ml measuring bottle, add an appropriate amount of methanol, sonicate to dissolve, let cool, add methanol to dilute to the mark, shake well, Reconfigure it into 0.2mg / ml timosaponin B-II, B-III, A-III reference substance solution, set aside.

[0103] Accurately weigh 20 mg of total saponins extract of Anemarrhena, put it in a 25ml volumetric flask, add an appropriate amount of methanol, d...

Embodiment 2

[0107] Embodiment 2 Determination of mangiferin content

[0108] Chromatographic column: Diamonsil from Dima Company R C 18 Column (250mm×4.6mm, 5μm); column temperature is 20°C.

[0109] Mobile phase: acetonitrile-water (15:85, v / v), (adjust pH=3.0 with phosphoric acid); flow rate: 1 ml / min; injection volume: 20 μL.

[0110] Detection wavelength: 254nm.

[0111] Precisely weigh 5.2 mg of mangiferin reference substance, put it in a 25ml measuring bottle, add appropriate amount of methanol, sonicate to dissolve, let it cool, add methanol to dilute to the mark, shake well, and prepare 0.208mg / ml mangiferin reference substance solution, set aside .

[0112]Accurately weigh 20 mg of total flavonoids extract of Anemarrhena, put it in a 25ml volumetric flask, add an appropriate amount of methanol, sonicate to dissolve, let it cool, add methanol to dilute to the mark, shake well, and then dilute to an appropriate concentration, then it is total flavonoids of Anemarrhena Sample s...

Embodiment 3

[0116] Embodiment 3 berberine content determination

[0117] High-performance liquid chromatography: Agilent 1100 system; Hangzhou British Spectrum chromatography workstation.

[0118] Column: Diamonsil TM C 18 (250mm×4.6mm, 5μm); the column temperature is 20°C; the injection volume is 20μl.

[0119] Mobile phase: water-acetonitrile-glacial acetic acid-triethylamine (67:33:0.3:0.8, v / v), detection wavelength: 345nm; flow rate: 1ml / min.

[0120] Precisely weigh 10.0mg of berberine hydrochloride, put it in a 25ml measuring bottle, add methanol to dissolve and make up to the mark, and configure it as a 0.4mg / ml stock solution, accurately draw 1.0ml of berberine stock solution, add methanol to dissolve and make up to 20ml , make 1ml of reference substance solution containing 20μg of berberine.

[0121] Precisely weigh 20 mg of Phellodendron Phellodendri extract, put it in a 25ml volumetric flask, add appropriate amount of methanol, sonicate to dissolve, let it cool, add metha...

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Abstract

The invention provides a medicinal composition containing an atractylodes rhizome extractive, which can be composed of the atractylodes rhizome extractive, timosaponin B-II and berberine, can be also composed of the atractylodes rhizome extractive, a rhizoma anemarrhenae extractive and a phellodendron bark extractive, or can be obtained by directly extracting from atractylodes rhizome, rhizoma anemarrhenae and phellodendron bark. The composition of the invention has obvious effect of reducing blood sugar, high content of effective ingredients, easy quality control, easy industrialization of preparation process; and the composition can be applied to the medicine for preventing and treating diabetes.

Description

technical field [0001] The present invention relates to a composition composed of various plant extracts, in particular to a pharmaceutical composition containing Atractylodes atractylodis extract, which is used for the prevention and treatment of diabetes. Background technique [0002] Diabetes Mellitus (DM) is a series of clinical syndromes caused by absolute or relative insufficiency of insulin in the body. Among diabetic patients, type II diabetes (Diabetes type II, non-Insulin Dependent Diabetes Mellitus, NIDDM) patients account for the vast majority. Due to the disorder of glucose metabolism, some complications will also be caused during the development of the disease, such as: hypoglycemia (Hypoglycemia), ketoacidosis (Ketoacidosis), nonketotic hyperosmolar coma (Nonketotic Hyperosmolar Coma), cardiac Vascular disease, chronic renal failure, retinopathy, neuropathy and microvascular disease, etc. There are three main types of drugs commonly used in the treatment of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/284A61P3/10A61K31/7048A61K31/4375A61K31/704
Inventor 黄成钢范明松唐意红李志雄孙兆林吴斌
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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