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Microfluidic biological chip sperm quality analyser

A technology of biochip and sperm quality, which is applied in the direction of microbial determination/inspection, biological testing, biochemical equipment and methods, etc., can solve complex problems, achieve low cost, improve accuracy and repeatability

Active Publication Date: 2010-06-09
深圳创怀医疗科技有限公司
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Problems solved by technology

This method requires the addition of some reactants and requires a complex process to complete
And similar to the method described in the above-mentioned patent, the results can only be roughly judged by comparing the colors with the naked eye to see if the sperm density exceeds 20 million per milliliter

Method used

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  • Microfluidic biological chip sperm quality analyser
  • Microfluidic biological chip sperm quality analyser
  • Microfluidic biological chip sperm quality analyser

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Embodiment Construction

[0026] Various preferred embodiments of the present invention will be described in more detail below in conjunction with the accompanying drawings.

[0027] Male sperm cells, due to the membrane capacitance characteristics of the cell membrane, the whole cell is non-conductive in the electric field of direct current and low frequency (according to the experimental results, for human sperm cells, the low frequency is below 5MHz). The principle of particle counting and analysis based on the non-conductivity of cells and other non-conductive particles is Coulter's principle. The principle is as figure 1 (a) and figure 1 As shown in (b), due to the effect of vacuum pressure, the cells / particles 22 suspended in the electrolyte 18 are sucked into the rear pool 23 from the front pool 21 through the micropore 20, and when the cells / particles 22 pass through the micropore 20 , the impedance at the micropore 20 will rise, and this impedance change leads to a pair of electrodes that de...

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Abstract

The invention discloses a microfluidic biological chip sperm quality analyser, which comprises a biological chip and a measurement host. The biological chip comprises a sample input module and a microchannel. The measurement host comprises a chip butt module, a fluid driving module, a signal detection processing module and a result display recording module. Driven by the fluid driving module, a sperm sample flows at a set flow velocity and in a set mode in the microchannel of the biological chip, and the sperm amount, the sperm concentration and the sperm motility in the tested sperm sample are obtained by the coulter principle and a unique algorithm. The invention also provides a sperm quality analysis method. The analyser of the invention realizes fully automatic high-throughout rapid analysis of the sperm sample. A user only needs to insert the biological chip comprising the sample into the host, then the analyser can rapidly output a test result report. The analyser has simple and convenient operation and low testing cost and is suitable for medical establishments at all levels and households.

Description

technical field [0001] The invention is a new type of medical testing equipment, which relates to the innovative application of microfluidic biochip technology in the field of sperm quality detection and analysis. Background technique [0002] Sperm information is the basis for diagnosing male fertility. Most sperm tests are done in hospitals. The test items include sperm density, activity rate, and deformity rate. The main detection methods used in the sperm examination in the hospital are microscope manual microscopy and computer-aided sperm quality analysis system (CASA). Microscopic examination has simple equipment and low cost, but human error is relatively large, and there are many factors that affect the test results, and the accuracy of the results is not high. With 100 cells, the same doctor may have an error of more than 50% in the two inspection results of the same sample, and the detection error between different doctors is even greater. Since the 1980s, the co...

Claims

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Application Information

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IPC IPC(8): G01N33/48G01N27/04C12Q1/02
Inventor 庄斌
Owner 深圳创怀医疗科技有限公司
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