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Slow-release growth factor double-layer artificial skin

A growth factor and artificial skin technology, applied in the field of medical devices, can solve the problems of high processing cost and immune rejection, and achieve the effects of good waterproofness, strong repairability and low rejection.

Active Publication Date: 2014-10-22
SHENZHEN QIKANG MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many of these products are obtained from allogeneic or heterogeneous skins through processing, and there are problems such as high processing costs and immune rejection.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1, artificial skin

[0044] Epidermis preparation:

[0045] (1) Apply a layer of concentrated sulfuric acid on the upper side of the polyurethane layer with a cotton swab, leave it for 2 hours, and clean it.

[0046] (2), adding the mixed solution of silk fibroin and chitosan in the mould, the concentration of the two in the mixed solution is 4% and 1% respectively.

[0047] After gradient drying, a uniform silk fibroin and chitosan film is prepared, and the film has a microporous structure.

[0048] (3) The above-mentioned two-layer film is compounded by applying pressure to prepare a skin layer, solidified with methanol solution, and dried in vacuum to remove methanol.

[0049] The preparation steps of the growth factor-loaded microspheres of the dermis:

[0050] (4) Mix 3% alginic acid solution and growth factor EGF to prepare alginic acid / EGF solution, the concentration of growth factor is 30ug / ml.

[0051] (5) The alginic acid / EGF solution was droppe...

Embodiment 2

[0055] Embodiment 2, artificial skin

[0056] Epidermis preparation:

[0057] (1) Apply a layer of concentrated sulfuric acid on the upper side of the silicone rubber with a cotton swab, leave it for 1 hour, and clean it.

[0058](2), add the mixed solution of silk fibroin and chitosan in the mould, the concentration of the two in the mixed solution is 3% and 1% respectively

[0059] After gradient drying, a uniform silk fibroin / chitosan film is prepared, which has a porous structure.

[0060] (3) The above-mentioned two-layer films are prepared by applying pressure and compounding to obtain a skin layer, and solidified with methanol solution, and then vacuum-dried to remove methanol.

[0061] The preparation steps of the growth factor-loaded microspheres of the dermis:

[0062] (4) Mix 1% alginic acid solution with growth factor EGF to prepare alginic acid / EGF solution, the concentration of growth factor is 30ug / ml.

[0063] (5) Drop the alginic acid / EGF factor solution i...

Embodiment 3

[0068] Embodiment 3, artificial skin

[0069] Epidermis preparation:

[0070] (1) Apply a layer of concentrated sulfuric acid on the upper side of the silicone rubber with a cotton swab, leave it for 1 hour, and clean it.

[0071] (2), adding the mixed solution of silk fibroin and chitosan in the mould, the concentration of the two in the mixed solution is 5% and 3% respectively.

[0072] After gradient drying, a uniform silk fibroin / chitosan film is prepared, which has a porous structure.

[0073] (3) The above-mentioned two-layer films are prepared by applying pressure and compounding to obtain a skin layer, and solidified with methanol solution, and then vacuum-dried to remove methanol.

[0074] The preparation steps of the growth factor-loaded microspheres of the dermis:

[0075] (4) Mix 1% alginic acid solution with growth factor EGF to prepare alginic acid / EGF solution, the concentration of growth factor is 30ug / ml.

[0076] (5) Drop the alginic acid / EGF factor solut...

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Abstract

The invention relates to a growth factor slow-release type double-layered artificial skin which is used for repairing injured skin with related growth factor slow-release functions and a preparation method thereof. The artificial skin is divided into two layers of an epidermal layer and an enderonic layer, wherein the epidermal layer is constituted by a micropore double-layered thin film with the functions of water proofing, ventilation and enderonic protection; the materials of the upper layer which contacts with air is polyurethane, or silicon rubber, or polyethylene glycol, or ethylene terephthalate and other medical materials; the lower layer which contacts with the dermis is a natural biological macromolecule thin film which is constructed by silk fibroin and chitosan; the enderonic layer of the artificial skin is constituted by collagen, polysaccharide and microspheres carrying growth factors related to skin regeneration and repairing; the microspheres have good slow-release function, and the slow-release period is equal to or slightly longer than the degradation period of the collagen and polysaccharide and can be matched with the skin regeneration and repairing period; and the thickness of the artificial skin is in a range of 0.5-1.5mm and can be regulated according to requirements.

Description

technical field [0001] The invention belongs to the field of medical equipment. More specifically, the present invention relates to an artificial skin for repairing skin damage and having related growth factor slow release function and its preparation method. technical background [0002] The skin not only protects a person from dirt or bacteria, but also keeps moisture from escaping from the body. As an important tissue and organ covering and protecting the body surface, the skin is very vulnerable to damage from trauma, burns, inflammation and other factors. When a large area of ​​skin is severely burned or damaged, doctors must immediately infuse fluids and protect the wound. If only a superficial layer of skin is damaged, new skin will regenerate. If a patient has suffered a severe burn, the skin cannot repair itself, and superficial skin from another part of the body is usually grafted onto the wound. [0003] Since there is no alternative source of skin, autologous ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/54A61L27/60A61F2/10
Inventor 佘振定谭荣伟王明波
Owner SHENZHEN QIKANG MEDICAL DEVICES
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