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Wild Juglans mandshurica bark water extract used for curing liver cancer

A water extract, a technology for treating liver cancer, applied in the field of wild walnut bark water extract, can solve the problems of inability to meet anti-tumor needs, serious adverse reactions, adverse reactions, etc. The effect of huge market potential

Inactive Publication Date: 2010-05-26
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Malignant tumors have become one of the main factors that threaten human life. Chemical drugs are still one of the main means of anticancer treatment today, but almost all anticancer drugs have relatively serious adverse reactions. Among many side effects, especially Nausea and vomiting are the most common. Others include hair loss and loss of appetite, which bring great pain to users.
Different drugs have great differences in the degree of adverse reactions, but in general chemical drugs have more serious adverse reactions than Chinese herbal medicines. However, there are still few Chinese herbal medicines that can be used to fight tumors, which cannot meet the existing anti-tumor needs.

Method used

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  • Wild Juglans mandshurica bark water extract used for curing liver cancer
  • Wild Juglans mandshurica bark water extract used for curing liver cancer
  • Wild Juglans mandshurica bark water extract used for curing liver cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 Study on anti-hepatocarcinoma efficacy and action mechanism of Juglans chinensis bark decoction

[0017] 1. The culture and passage of human liver cancer cell line SMMC-7721.

[0018] Human liver cancer SMMC-7721 cells were inoculated into RPMI1640 culture medium containing 10% newborn calf serum, 100U / ml penicillin / streptomycin, and placed in a 37°C 5% CO2 incubator. After the cells became full, use 0.25% pancreas. Protease digestion and subculture, subculture once every 3-5 days.

[0019] 2. Morphological observation.

[0020] Digest the cells and inoculate them in a 6-well cell culture plate, place them in a 37°C 5% CO2 incubator for 4 hours, add pecan bark decoction, set up 4 drug experimental groups, 1 PBS negative control group, and a blank The final drug concentrations of the control group and the experimental group were 34mg / L, 17mg / L, 8.5mg / L, 1.7mg / L. The negative control group was added with 10μl PBS, and the blank control group was without any components....

Embodiment 2

[0026] Example 2 Study on the therapeutic effect of Walnut tree bark decoction on tumor growth inhibition, tumor formation and immune stimulation of BALB / c mouse liver cancer model

[0027] 1. In vitro mice transplanted tumor inhibition experiment with a water decoction of walnut tree bark.

[0028] Take 50 SPF grade BALB / c female mice and raise them in an SPF environment. When SMMC-7721 cells are cultured to the logarithmic growth phase, take 2×10 7 The cells were inoculated under the skin of the right back of the experimental mouse, and the administration was started when the tumor tissue grew to about 1×1cm. In the experiment, BALB / c mice were randomly divided into a negative control group (normal saline), a different dose group of walnut tree bark decoction, and a positive control group (cyclophosphamide). Inject drugs into the tumor, once every other day. The subcutaneous tumor mass was removed before treatment, 1 week, 2 weeks, 3 weeks, and 4 weeks after treatment, the aver...

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PUM

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Abstract

The invention discloses a novel wild Juglans mandshurica bark water extract used for curing liver cancer. The water extract is prepared according to the following steps: soaking the Juglans mandshurica bark into water for 24h, wherein the weight of water is 5 times of that of the Juglans mandshurica bark, heating up to 100 DEG C and lasting for 30min, filtering, repeatedly extracting the filter residue once, mixing the filter liquor of the two times, and heating and concentrating. The invention also discloses an application of the wild Juglans mandshurica bark water extract in preparing medicines for curing liver cancer. The Juglans mandshurica bark in China has rich resource and wide source; and the technical scheme provided by the invention fully utilizes the natural medicine material advantage of our country and gives plays to the culture essence of traditional Chinese medical science and traditional Chinese medicine.

Description

Technical field [0001] The invention relates to a water extract of wild walnut tree bark for treating liver cancer. Background technique [0002] Malignant tumors have become one of the main factors threatening human life. Chemical drugs are still one of the main methods of anti-cancer treatment. However, almost all anti-cancer drugs have serious adverse reactions. Among the many side effects, especially Nausea and vomiting are the most common. Others include hair loss and loss of appetite, which cause great pain to the user. Different drugs have different levels of adverse reactions, but in general chemical drugs have more serious adverse reactions than Chinese herbal medicines. However, there are fewer Chinese herbal medicines that can be used for anti-tumor, which cannot meet the existing anti-tumor needs. . Summary of the invention [0003] The technical problem to be solved by the present invention is to provide a novel water extract of wild walnut tree bark for the treatme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61P35/00A61P1/16A61K129/00
Inventor 张咏莉
Owner GUANGDONG PHARMA UNIV
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