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Medicament for inhibiting asodilatatioin

A technology of vasodilation and medicine, which is applied in the field of medicines for preparing its main active ingredients from P. loropetalum, and can solve problems such as unseen

Active Publication Date: 2010-05-19
景德镇市农牧渔业科学研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, no one has used Pyramida or its extracts for the purpose of inhibiting vasodilation or promoting vasoconstriction

Method used

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  • Medicament for inhibiting asodilatatioin
  • Medicament for inhibiting asodilatatioin
  • Medicament for inhibiting asodilatatioin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 The extraction of the crude extract of Pyracha chinensis

[0030] The crude matter of P. saponifera was extracted by biological enzymatic hydrolysis. The specific process is: raw material sampling analysis and testing before the production line → raw material acceptance → deep cleaning → enzymatic hydrolysis of combined bacteria → inactivation → dynamic temperature immersion extraction → low-temperature concentration → instant freezing → high-speed centrifugal sedimentation separation → spray drying → packaging inspection → Baihuahua Crude wood extract.

[0031] The specific extraction method is to crush the fresh material of P. chinensis. The biobroken product of P. candidum was obtained by enzymatic hydrolysis with combined bacteria, extracted by dynamic warm soaking method (temperature 85°C, time 120m, pH value 6.5±0.2), warm soaking extraction time was 16 hours, and the extract was obtained. First use alcohol extraction and water precipitation method to ...

Embodiment 2

[0035] Example 2 Preliminary Analysis Report on Chemical Components of P.

[0036] 1. Sample preparation

[0037] Finely weigh 1.06 mg of crude powder, dissolve in 1 mL of 50% methanol, and pass through a 0.45 μm microporous membrane to obtain the product.

[0038] 2. Chromatographic conditions

[0039] High-performance liquid chromatography: Agilent 1200 series high-performance liquid chromatography (Agilent Technologies, USA), including a diode array detector, a quaternary gradient pump, an online degasser, and an autosampler.

[0040] Column: YMC-Pack Pro C 18 (150mm×3.0mm ID, 5μm);

[0041] Mobile phase: A (methanol), B (0.1% formic acid H 2 O)

[0042] Gradient elution (0→35min, A: 10%→98%; 35min-40min, A: 98%→98%;);

[0043] Flow rate 0.3mL / min;

[0044] UV scanning range: 200-400nm;

[0045] Detection wavelength: 200-400nm; Column temperature: 40°C.

[0046] 3. Mass Spectrometry Conditions

[0047] 1. Mass spectrometer: QTRAP TM Type quadrupole-linear ion tra...

Embodiment 3

[0069] Example 3 Effects of the crude extract of P. chinensis on the vasodilation induced by bradykinin in rats

[0070] 1. Materials

[0071] Animals: Wistar rats, male, weighing 250 g, provided by the Institute of Experimental Animals, Chinese Academy of Medical Sciences, certificate number, SCXK (Beijing) 2008-0004.

[0072] Tested product: Crude extract of P. chinensis, brown powdery solid, provided by Jiangxi Deyu Group. Prepare to the required concentration with normal saline before use.

[0073] Experimental liquid:

[0074] 1) KH solution (in 2000ml distilled water, add NaCl: 13.7918g; KCl: 0.7008g; CaCl2: 0.56605g; anhydrous MgSO4: 0.2841g; KH2PO4: 0.3212g; NaHCO3: 4.1803g; Glucose: 4.3994g. magnetic stirring, spare)

[0075] 2) Bradykinin with a final concentration of 3 μmol / L, prepared with physiological saline, stored at -20°C;

[0076] 3) Potassium chloride solution with a final concentration of 60mmol / L.

[0077] 2. Method

[0078] 1) Rats were anesthetize...

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Abstract

The invention relates to a medicament for inhibiting asodilatatioin. A main active component of the medicament is prepared from Loropetalum chinense. Through animal experiments and in vitro experiments on crude extract of the Loropetalum chinense, the crude extract of the Loropetalum chinense is verified to have obvious effect of inhibiting the asodilatatioin, have good safety, and not to influence platelet aggregation of animals or blood coagulation.

Description

Technical field: [0001] The invention relates to a medicine for inhibiting vasodilation, in particular to a medicine whose main active ingredient is prepared from loropetalum. Background technique: [0002] Loropetalum has tenacious vitality, strong natural regeneration and bonding ability, and the most amazing phenomenon is that loropetalum and loropetalum can fuse and grow together. White loropetalum, also known as white flower loropetalum, is a kind of loropetalum. [0003] According to the theory of traditional Chinese medicine, P. chinensis has the effect of astringent and hemostasis, which can be used to heal wounds inside and outside the body. [0004] However, no one has used Pyramida or its extracts for the purpose of inhibiting vasodilation or promoting vasoconstriction. Invention content: [0005] The purpose of the present invention is to develop a kind of medicine that is prepared by using P. loropetalum as raw material. [0006] The present invention finds...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P9/00A61K127/00A61K133/00A61K135/00
Inventor 刘浩元李晓滨曲淑娟
Owner 景德镇市农牧渔业科学研究所
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