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Functional superparamagnetic nano particle with uniform particle size and preparation method thereof

A magnetic nanoparticle and nanoparticle technology, applied in the field of amino superparamagnetic nanoparticles and their preparation, can solve the problems of difficult biological functionalization of surface groups, insufficient uniform particle size, difficult biological application, etc., and achieve biological functionalization. Effect

Inactive Publication Date: 2011-10-05
盐城永鑫塑料制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional superparamagnetic nanoparticles as biosensing materials still have shortcomings such as insufficiently uniform particle size, difficulty in biological applications, and difficulty in biological functionalization of surface groups; for the synthesis of superparamagnetic nanoparticles with uniform particle size, And to make it convenient for biological functionalization has become a hot spot in current research

Method used

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  • Functional superparamagnetic nano particle with uniform particle size and preparation method thereof
  • Functional superparamagnetic nano particle with uniform particle size and preparation method thereof
  • Functional superparamagnetic nano particle with uniform particle size and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1, Fe 3 o 4 Synthesis of biofunctionalized superparamagnetic nanoparticles as magnetic nanoparticle cores

[0063]

[0064] (1) Synthesis of magnetic nanoparticles

[0065] Specific steps are as follows:

[0066] Iron (III) acetylacetonate (1.766g, 0.337mL, 5mmol), 1,2-hexadecanediol (6.461g, 25mmol), oleic acid (4.237g, 4.761mL, 15mmol), oleylamine (4.012g, 4.935mL, 15mmol) was dissolved in 50mL of dibenzyl ether, magnetically stirred under the condition of continuously feeding nitrogen, and the mixed solution was heated to 200°C for 2 hours under the protection of nitrogen, and then heated to 300°C for another hour, and then transferred to Turn on the heat source and cool to room temperature, add 100mL ethanol, a black precipitate is formed. Centrifuge at a speed of 6000 rpm for 10 minutes, centrifuge to separate the black precipitate, and disperse it in 40 mL of n-hexane solution containing 1 mL of oleic acid and 1 mL of oleylamine, and centrifuge at a...

Embodiment 2

[0074] Example 2, CoFe 2 o 4 Synthesis of biofunctionalized superparamagnetic nanoparticles as magnetic nanoparticle cores

[0075]

[0076] (1) Synthesis of magnetic nanoparticles

[0077] Specific steps are as follows:

[0078] Iron (III) acetylacetonate (1.413g, 4mmol), cobalt (II) acetylacetonate (0.5503g, 2mmol), 1,2-hexadecaneol (7.753g, 30mmol), oleic acid (5.084g, 5.713mL , 18mmol), oleylamine (4.814g, 5.922mL, 18mmol) were dissolved in 60mL of dibenzyl ether, magnetically stirred under the condition of continuously feeding nitrogen gas, and the mixed solution was heated to 200°C for 2 hours under the protection of nitrogen gas, and then the temperature was raised Heat at 300°C for another hour, remove the heat source and cool to room temperature, add 100mL of ethanol, a black precipitate is formed. Centrifuge at a speed of 6000 rpm for 10 minutes, centrifuge to separate the black precipitate, and disperse it in 40 mL of n-hexane solution containing 1 mL of olei...

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Abstract

The invention discloses a functionable superparamagnetic nano particle with uniform particle size. The nano particle is provided with a superparamagnetic nano particle core, and the magnetic nano particle core is connected with a plurality of water-soluble polymer chain segments and organic chain segments containing modifiable amino terminal groups respectively; and the magnetic nano-particle core is an MFe2O4 superparamagnetic nano particle, wherein metal M is one of Fe, Co and Mn, namely the magnetic nano particle is one of Fe3O4, CoFe2O4 or MnFe2O4, the particle size of the magnetic nano particle is between 4 and 12nm, and the particle size distribution is not more than 20 percent. The synthesized material can be widely applied to targeted release of medicaments, magnetic fluid hyperthermia, biofluorescent detection and the like. The synthesized magnetic nano-particle has uniform particle size, which ensures that the nano-particle meets the demand of biological application. At the same time, the surface of the nano-particle is modified with an organosilicon compound with an amino group remained at a terminal, and the amino group can be widely combined with bio-functional substances, thereby ensuring that the synthesized magnetic nano-particle can conveniently perform the bio-functionalization.

Description

technical field [0001] The invention belongs to the technical field of biological functional materials, and in particular relates to a superparamagnetic nanoparticle containing modifiable amino groups with a uniform particle size and a preparation method thereof. Background technique [0002] Superparamagnetic nanoparticles have special magnetic properties, and their magnetic properties will change with changes in the external environment, which makes them have broad application prospects in chemical and biological sensing. However, traditional superparamagnetic nanoparticles as biosensing materials still have shortcomings such as insufficient uniform particle size, difficulty in biological applications, and difficulty in biological functionalization of surface groups; for the synthesis of superparamagnetic nanoparticles with uniform particle size, And making it convenient for biological functionalization has become a hotspot of current research. [0003] The invention synt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/34C04B35/26C04B35/622C04B35/628C08F292/00
Inventor 范曲立黄维李波
Owner 盐城永鑫塑料制品有限公司
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