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Application of notoginseng and extract thereof in preparing medicament for curing and/or preventing diabetic microangiopathies

A technology for microvascular disease and diabetes, which is applied in the field of preparing medicines for treating and/or preventing diabetic microangiopathy, can solve the problems of lack of action mechanism of components, complex components, research and other problems, and achieves improvement of renal function, inhibition of fibrin synthesis, improvement of The effect of microcirculation

Active Publication Date: 2013-02-20
许淑清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complexity of the ingredients in the total saponins of Panax notoginseng, it is not yet clear which ingredients play the main therapeutic role, and no one has done a comprehensive study on the mechanism of action between the ingredients.

Method used

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  • Application of notoginseng and extract thereof in preparing medicament for curing and/or preventing diabetic microangiopathies
  • Application of notoginseng and extract thereof in preparing medicament for curing and/or preventing diabetic microangiopathies
  • Application of notoginseng and extract thereof in preparing medicament for curing and/or preventing diabetic microangiopathies

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0138] Take notoginseng and grind it into 1000g of coarse powder, add 7000ml of 65% ethanol to extract for 7 hours, collect the extract, filter, take the filtrate to recover the ethanol until it has no alcohol smell, add water to make a solution containing 0.5g of crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, gradient elution with different concentrations of ethanol, the ethanol concentration is adjusted from 5% to 95% within 6 hours , flow rate 4.5BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and concentrate To a clear paste with a relative density of 1.13 (60° C.), the active ingredient of Panax notoginseng saponins is obtained, and water for injection is added to adjust to contain 100 m...

Embodiment 2

[0141] Take notoginseng and grind it into 1000g of coarse powder, add 10000ml of 50% ethanol to extract for 6 hours, collect the extract, filter, take the filtrate to recover the ethanol until it has no alcohol smell, add water to make a solution containing 0.4g of crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, carry out gradient elution with different concentrations of ethanol (the ethanol concentration is adjusted from 5% to 95% within 5.5 hours ), the flow rate is 5.0BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and Concentrate to a clear paste with a relative density of 1.15 (60°C), dry it to obtain the active ingredient of Panax notoginseng saponins, add water for injection to adjust t...

Embodiment 3

[0144] Take notoginseng and grind it into coarse powder 1000g, add 75% ethanol 7500ml to extract for 8 hours, collect the extract, filter, take the filtrate to recover ethanol until it has no alcohol smell, add water to make a solution containing 0.6g crude drug per 1ml, and use a macroporous resin column (Class D macroporous resin, resin volume 3000ml, resin bed height to diameter ratio is about 8) and alumina adsorption, carry out gradient elution with different concentrations of ethanol (the ethanol concentration is adjusted from 5% to 95% within 6.5 hours ), the flow rate is 4.0BV / h, discard the eluate containing ethanol concentration other than 30% to 70%, collect the eluate containing ethanol concentration above 30% to below 70%, recover the solvent under reduced pressure below 65°C and Concentrate to a clear paste with a relative density of 1.16 (60°C) to obtain the active ingredient of Panax notoginseng saponins, add 0.30% (weight ratio) of activated carbon for injectio...

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Abstract

The invention relates to a new application of pseudo-ginseng, pseudo-ginseng extract, panax notoginseng saponins, and panax notoginseng saponins composite, namely, a new application in preparing medicament for curing and / or preventing diabetic microangiopathies.

Description

technical field [0001] The present invention relates to new uses of notoginseng, notoginseng extracts, total notoginseng saponins and a composition of notoginseng total saponins, especially in the preparation of medicines for treating and / or preventing diabetic microangiopathy. Background technique [0002] Panax notoginseng is a plant of Araliaceae, which has the effects of promoting blood circulation, dispelling blood stasis, reducing inflammation and relieving pain. In addition to the above effects, it also has the special effect of reducing human blood coagulation factors. Fg is a plasma globulin synthesized by the liver. Its main function is to participate in the blood coagulation process. Elevated fg can increase the incidence of heart and cerebrovascular diseases. Oral administration of raw Panax notoginseng powder can reduce the level of fg, which is beneficial to control the occurrence of cardiovascular and cerebrovascular diseases. Wang Nan, Wan Jianbo, Li Ming...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61P3/10A61P9/00A61P9/10A61P13/12A61K125/00
Inventor 许淑清赵学伟陈明
Owner 许淑清
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