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Integrated artificial cornea and preparing method thereof

An artificial cornea, one-piece technology, applied in the direction of eye implants, etc., to achieve the effect of preventing separation, preventing leakage and infection, and good biocompatibility

Inactive Publication Date: 2011-08-17
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above situation, the present invention will provide a new form of integrated artificial cornea to solve the above problems

Method used

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  • Integrated artificial cornea and preparing method thereof
  • Integrated artificial cornea and preparing method thereof
  • Integrated artificial cornea and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024]Dissolve 10g of polyvinyl alcohol in 80g of dimethyl sulfoxide (DMSO), add 10g of graphite powder (10-100μm in particle size) and mix well, then add 120g of sodium chloride particles (10-300μm in particle size) and mix well The obtained mixture is put into a special mold for artificial cornea and molded (as shown in the figure, the crescent shape is formed by curved edges with different curvatures), and then frozen together with the mold at -20°C to -40°C for 30 minutes, and then After thawing at room temperature for 30 minutes, take it out of the mold and soak in deionized water for 48-96 hours to completely dissolve and remove sodium chloride, fully dissolve the solvent DMSO and replace it with water to obtain porous polyvinyl alcohol with micropores distributed in the structure Hydrogel porous structure skirt scaffold blank.

[0025] According to the requirements of use, punch a hole with a diameter of 5-7 mm in the center of the above-mentioned skirt bracket blank, a...

Embodiment 2

[0028] Dissolve 10g of polyvinyl alcohol in 83g of dimethylsulfoxide (DMSO), add 7g of graphite powder (10-100μm in particle size) and mix well, then add 150g of sodium chloride particles (10-300μm in particle size) and mix well The obtained mixture is put into a special mold for artificial cornea, and then molded together with the mold at -20°C to -40°C for 30 minutes, then thawed at room temperature for 30 minutes, taken out of the mold and soaked in deionized water for 48 to 48 minutes. After 96 hours, the sodium chloride was completely dissolved and removed, and the solvent DMSO was fully dissolved and replaced by water to obtain a porous polyvinyl alcohol hydrogel porous structure skirt stent blank with micropores distributed in the structure.

[0029] According to the requirements of use, punch a hole with a diameter of 5-7mm in the center of the above-mentioned skirt stent blank, and add an appropriate amount of 20wt% polyvinyl alcohol solution (the solvent is water / DMSO...

Embodiment 3

[0032] Dissolve 10g of polyvinyl alcohol in a mixed solvent of 84g of dimethylsulfoxide and water (water / DMSO mixture containing 20wt% water), add 6g of graphite powder (10-100μm in particle size) and mix well, then add 100g of sodium chloride Particles (particle size range 10-300μm) and stirred evenly to obtain a mixture, take the mixture and put it in a special mold for artificial cornea and mold it, freeze it together with the mold at -20℃~-40℃ for 30min, and then thaw at room temperature for 30min , taken out from the mold and soaked in deionized water for 48 to 96 hours to completely dissolve and remove sodium chloride, fully dissolve the solvent DMSO and replace it with water to obtain a porous polyvinyl alcohol hydrogel porous structure with micropores distributed in the structure Skirt bracket blanks.

[0033] Punch a hole with a diameter of 5-7mm in the center of the above-mentioned skirt bracket blank, add an appropriate amount of 20wt% polyvinyl alcohol solution (th...

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Abstract

The invention relates to an integrated artificial cornea and a preparing method thereof. The optical center of the artificial cornea is polyvinyl alcohol hydrogel containing 80 to 90 weight percent of water; a skirt stent is porous polyvinyl alcohol hydrogel which contains 70 to 90 weight percent of water and 0 to 15 weigh percent of graphite powder and is distributed with micropores; and an neighboring periphery combining part of the optical center part and the skirt stent part is an integrated transitional structure in mutual crossing integration. The integrated artificial cornea is prepared by the following steps: firstly, fully dissolving polyvinyl alcohol by a solvent, adding the graphite powder and a pore forming agent of water soluble particles to perform compression molding, and fully soaking and washing the mixture in deionized water after freezing and thawing to obtain a skirt stent blank; and then, drilling a central hole in the optical center, dripping polyvinyl alcohol solution into the hole and performing compression molding, performing freezing and thawing repeatedly, and fully soaking and washing the skirt stent blank to obtain the artificial cornea. The artificialcornea has better biocompatibility and flexibility, is resistant to tear and drag, is favorable for the biological healing between regenerated tissues and the skirt stent, can prevent the leakage andthe infection of aqueous humor, and can effectively avoid spontaneous dislocation after transplant.

Description

technical field [0001] The invention relates to an artificial cornea and a preparation method thereof. Background technique [0002] Artificial corneas are often the only hope for eventual salvage and restoration of vision after multiple failed corneal transplants, or in conditions such as alkali burns, lack of tears, severe corneal vascularization, etc. [0003] Most of the currently designed artificial corneas are penetrating artificial corneas, which are usually non-integral structures composed of polymethyl methacrylate, quartz and other optical mirror columns and porous polytetrafluoroethylene skirt fixing brackets. The preparation method is complex, the implantation operation is cumbersome, and the compatibility with biological tissues is poor, resulting in various complications after artificial cornea implantation, among which the spontaneous dislocation of artificial cornea is one of the fatal complications after transplantation. First, the main reason is the lack o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/14
Inventor 李玉宝张利左奕李吉东
Owner SICHUAN UNIV
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