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Application of 2-(alpha- hydroxyl amyl) potassium benzoate in preventing and/or treating senile dementia

A kind of Alzheimer's disease, hydroxyamyl technology, applied in the alleviation and/or treatment of Alzheimer's disease or symptoms, a pharmaceutical composition for alleviation and/or treatment of Alzheimer's disease or symptoms, prevention field, can solve the problem of dl-PHPB that has not yet been seen Treating problems such as Alzheimer's

Inactive Publication Date: 2010-01-20
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there is no report of dl-PHPB treating senile dementia

Method used

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  • Application of 2-(alpha- hydroxyl amyl) potassium benzoate in preventing and/or treating senile dementia
  • Application of 2-(alpha- hydroxyl amyl) potassium benzoate in preventing and/or treating senile dementia
  • Application of 2-(alpha- hydroxyl amyl) potassium benzoate in preventing and/or treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0132] Example 1. Study on chronic cerebral ischemia model: dl-PHPB can improve short-term memory and spatial orientation dysfunction in rats with cerebral insufficiency

[0133] Materials and methods

[0134] 1. Reagents and medicines

[0135] dl-PHPB is provided by the synthesis laboratory of our institute, the chemical purity is 98.5% (as determined by HPLC method), and it is prepared with distilled water. Piracetam tablets, produced by Tianjin Jinshi Pharmaceutical Co., Ltd. Superoxide dismutase (SOD) kits, malondialdehyde (MDA) kits, choline acetyltransferase (ChAT) kits, and Coomassie brilliant blue protein assay kits were purchased from Nanjing Jiancheng Bioengineering Institute. Neutral red and firm blue were purchased from Sigma. Lithium carbonate was produced by Beijing Chemical Reagent Company. Triton X-100 was purchased from Beijing Zhongshan Biotechnology Co., Ltd. Glial fibrillary acidic protein (GFAP) polyclonal antibody was purchased from Chemicon. Brain-...

Embodiment 2

[0178] Example 2. Research on β-amyloid peptide dementia model: dl-PHPB can significantly improve memory and spatial disorientation in rats caused by β-amyloid peptide (25-35)

[0179] Materials and methods

[0180] 1. Reagents and medicines

[0181] dl-PHPB was provided by the synthesis room of our institute and prepared with PBS. Aβ (25-35) Purchased from Sigma Corporation. Superoxide dismutase (SOD) kit, malondialdehyde (MDA) kit, choline acetyltransferase (ChAT) kit, and Coomassie brilliant blue protein assay kit were purchased from Nanjing Jiancheng Bioengineering Institute.

[0182] 2. Instrument

[0183] Morris water maze automatic monitor and microplate reader are the same as above.

[0184] 3. Model building

[0185] Male Wistar rats, 10 months old, weighing about 600 grams, placed 2 animals in each cage, kept the room temperature at 23±1°C, and had free access to food and water. Anesthetize the rat with pentobarbital sodium (45mg / kg), fix its abdominal positio...

Embodiment 3

[0204] Example 3 Research on Rapid Aging Mouse Model: Improvement Effect of dl-PHPB on Learning and Memory Defects of Rapid Aging Mice

[0205] Materials and methods

[0206] 1. Reagents and medicines

[0207] dl-PHPB was provided by the synthesis laboratory of our institute, with a chemical purity of 98.5% (as determined by HPLC method), and was prepared with distilled water. Superoxide dismutase (SOD) kit, malondialdehyde (MDA) kit, choline acetyltransferase (ChAT) kit, adenosine triphosphate (ATPase) kit, Coomassie brilliant blue protein assay kit were purchased from Nanjing Jiancheng Institute of Bioengineering.

[0208] 2. Instrument

[0209] STT-2 platform jumper and water fan were developed by Institute of Materia Medica, Chinese Academy of Medical Sciences. MQX 200 microplate reader is a product of Bio Tek Instruments in the United States.

[0210] 3. Animals

[0211] 10-month-old SAMP8, male, SPF grade, was purchased from Beijing Weitong Lihua Experimental Anima...

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Abstract

The invention discloses application of 2-(alpha- hydroxyl amyl) potassium benzoate salt in preparing a medicament for preventing, alleviating and / or treating senile dementia or symptoms of the senile dementia. The invention also discloses a medicinal composition for preventing, alleviating and / or treating the senile dementia or symptoms of the senile dementia. The medicinal composition contains the effective amount of 2-(alpha-hydroxyl amyl) potassium benzoate salt for prevention or treating, and optional pharmaceutically acceptable carriers and / or auxiliary materials. The invention also discloses a method for preventing, alleviating and / or treating the senile dementia or symptoms of the senile dementia. The method comprises a step of applying the effective amount of 2-(alpha-hydroxyl amyl) potassium benzoate salt for treatment or the medicinal composition containing the effective amount of 2-(alpha-hydroxyl amyl) potassium benzoate salt for treatment to a patient suffering from the senile dementia.

Description

technical field [0001] The invention relates to the application of potassium salt of 2-(alpha-hydroxypentyl)benzoate in the preparation of medicines for preventing, alleviating and / or treating senile dementia diseases or symptoms. The senile dementia is selected from Alzheimer's disease, vascular dementia or a mixed type of both; the senile dementia disease or symptom is selected from memory loss, low cognitive function, slow thinking or spatial orientation disorder. The present invention also relates to a pharmaceutical composition for preventing, alleviating and / or treating senile dementia diseases or symptoms, which contains a preventive or therapeutic effective amount of potassium salt of 2-(α-hydroxypentyl)benzoate, and optionally pharmaceutically acceptable carriers and / or excipients. The pharmaceutical composition may be in a dosage form selected from the group consisting of solutions, suspensions, emulsions, pills, capsules, powders, controlled release or sustained re...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P25/28A61P25/00
Inventor 王晓良赵万红杨靖华王玲李江徐少峰冯楠马士平
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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