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Alpha-calcium sulfate hemihydrates/beta-tertiary calcium phosphate porous granular-type composite artificial bones and preparation method thereof

A technology of tricalcium phosphate particles and calcium sulfate hemihydrate, which is applied in the field of medical materials, can solve the problem of difficulty in controlling the osteogenic performance and degradation performance of composite artificial bones, affecting product quality, inability to effectively control the spraying dosage of α-calcium sulfate hemihydrate, Spray uniformity β-tricalcium phosphate particle porosity and pore diameter to achieve the effect of ensuring in-situ curing performance and degradation performance, controllable degradation, and shortening the preparation cycle

Active Publication Date: 2009-12-09
BEIJING ZHONGNUO HENGKANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the preparation method of the invention has the following defects: first prepare β-tricalcium phosphate particles and α-calcium sulfate hemihydrate powder respectively, then stir them into a paste with dehydrated alcohol and α-calcium sulfate hemihydrate, and directly mix them with β-phosphate The surface of the tricalcium phosphate particles is sprayed with α-calcium sulfate hemihydrate. This method can only form a layer of α-calcium sulfate hemihydrate powder on the surface of the β-tricalcium phosphate particles, but cannot completely enter the internal pores of the β-tricalcium phosphate particles, and cannot Effectively control the spray dosage, spray uniformity and β-tricalcium phosphate particle porosity and pore diameter of α-calcium sulfate hemihydrate, which makes it difficult to control the osteogenesis and degradation properties of the composite artificial bone, which affects product quality

Method used

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  • Alpha-calcium sulfate hemihydrates/beta-tertiary calcium phosphate porous granular-type composite artificial bones and preparation method thereof
  • Alpha-calcium sulfate hemihydrates/beta-tertiary calcium phosphate porous granular-type composite artificial bones and preparation method thereof
  • Alpha-calcium sulfate hemihydrates/beta-tertiary calcium phosphate porous granular-type composite artificial bones and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 Preparation of α-calcium sulfate hemihydrate / β-tricalcium phosphate porous granular composite artificial bone

[0050] (1) Take a healthy bovine femur and remove its surface soft tissue. Use a trephine with an inner diameter of 8mm to drill the femoral head and cancellous bone at the distal end of the femur. After soaking in sodium and hydrogen peroxide solution to remove cells and degrease, rinse with distilled water, boil in distilled water for 10 hours, rinse with running water for 3 hours, rinse with deionized water twice, dehydrate with 70%-100% gradient alcohol, and then dry at 50°C for 4 sky. The above-mentioned processed material was preliminarily calcined in a high-temperature calciner at a heating rate of 10°C / min, and calcined at 800°C for 3 hours. The calcined bone was taken out and soaked in 1M (NH 4 ) 2 HPO 4 In the solution for 24 hours, remove the excess liquid, take out the material and dry it again at 50°C for 4 days. The dried material ...

Embodiment 2

[0062] Embodiment 2: physical and chemical properties and index detection

[0063] Test the new product, provide test results and photos, and prove that the purpose of the invention has been achieved.

[0064] The single-phase β-TCP porous particles prepared in Example 1 were subjected to scanning electron microscopy, X-ray diffraction (XRD), porosity and biomechanical detection respectively. Scanning electron microscope at low magnification (×40) shows that the obtained material is a honeycomb porous structure, which retains the porous space structure of natural cancellous bone. The pore size and porosity are similar to that of cancellous bone, and the size of the macropores is between 50-600um. , under a high magnification lens (×3000), it can be seen that the walls of the macropores of the material are densely covered with microporous structures, the size of which is about 1um, and the connectivity between the pores is good, such as Figure 8 shown. Compared with the stan...

Embodiment 3

[0066] Embodiment 3: Degradation experiment in vitro and in vivo

[0067] The α-CSH / β-TCP composite artificial bone prepared in Example 1 was prepared as a standard with a size of 12×8 mm, placed in a simulated body fluid with an initial pH value of 7.4, and kept at a constant temperature in a 37°C incubator without changing the fluid. Measure once a day in the first week, and then measure the pH value of the soaking solution with a pH meter every week until the pH value is constant and does not change. Then place the above test pieces in 50ml SBF solution with an initial pH value of 7.4, place them in an incubator at 37°C, store them at a constant temperature, change the solution every 2 days, and change the solution 30ml each time; at 4w, 8w, Measure the residual weight (Wr) of the specimen after drying to constant weight at 12w and 16 weeks, and calculate the in vitro degradation rate W% of the material = [100(Wo-Wr) / Wo].

[0068] During the degradation process of α-CSH / β-...

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Abstract

The invention discloses a method for preparing alpha-calcium sulfate hemihydrates (alpha-CSH) / beta-tertiary calcium phosphate (beta-TCP) porous granular-type composite artificial bones, which is characterized in that the alpha-CSH is directly synthesized on the surface and / or in the pores of the beta-TCP granules synchronously by the hydrothermal synthesis process and finally the alpha-CSH / beta-TCP porous granular-type artificial bones is prepared. The invention has the advantages that the preparation process is simpler, the preparation period can be effectively reduced, and the preparation efficiency is improved; the proportion between alpha-CSH and beta-TCP phases of the granular-type composite artificial bones can be effectively controlled, thereby controlling the pore structure of the artificial bone granules; meanwhile, the invention guarantees the in-situ solidifying performance and degrading performance of the composite artificial bones, controls the evenness of the product and the porosity and pore diameter of the beta-TCP granules, improves the bone-formation performance and degrading performance of the composite artificial bones and further improves the quality of the product, thereby finally obtaining the composite artificial bones having self-solidifying performance and controllable degradation and having a certain biomechanical strength. The invention has good application and market prospect.

Description

technical field [0001] The present invention relates to a preparation method of composite artificial bone and the products prepared therefrom. Specifically, the porous particles of β-tricalcium phosphate are directly synthesized into α-calcium sulfate hemihydrate / β-tricalcium phosphate by hydrothermal synthesis method. The invention relates to a calcium porous particle type composite artificial bone, which belongs to the field of medical materials. Background technique [0002] Inorganic composite artificial bone belongs to the category of bioceramic materials. In the past 50 years, bioceramics has undergone considerable development. The initial research targets are materials that are not biologically active and have minimal interaction with the body. These bioceramics are referred to as first-generation biomaterials. The research on the second generation of bioceramic materials began in the 1980s. Its research goal is to have a positive interaction with living tissues. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/56A61L27/54A61L27/02A61L27/12
Inventor 毛克亚王征王岩李江涛杨云
Owner BEIJING ZHONGNUO HENGKANG BIOTECH
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