Composite biomaterial and preparation method and application thereof
A technology of composite biomaterials and derivatives, applied in the field of medicine, can solve problems such as poor fatigue resistance, poor degradability, and easy fracture, and achieve strong mechanical properties, good biocompatibility, and safe use
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Embodiment 1
[0024] Composite biomaterial composed of 1,4-butanediol diglycidyl ether (BDDE) cross-linked cHA gel and HAP. The preparation method is as follows:
[0025] Method 1.1: (1) Mix 1g of sodium hyaluronate (SH, with an average molecular weight of 1 million Daltons) and 0.25g of HAP (average particle size of 100-500μm), and then mix it with 5ml of 1% NaOH solution containing 50mg of BDDE , reacted at 50°C for 2-4h, added 40ml of distilled water, and stood at 25°C for 8-16h to obtain a block gel. (2) Freeze-dry the bulk gel for 6-12 hours, purify it with physiological saline for 10 hours, dehydrate it with ethanol, dry it under reduced pressure, cut or crush it, and sterilize it with ethylene oxide to obtain the product.
[0026] Method 1.2: (1) According to the step (1) in method 1.1 to obtain block gel. (2) Add an equal volume of 1.8% sodium chloride solution to soak the block gel for 4 hours, then purify it with physiological saline for 4-6 hours, cut or crush it, freeze-dry it...
Embodiment 2
[0037] Composite biomaterial composed of adipate dihydrazide (ADH) cross-linked cHA gel and HAP. The preparation method is as follows:
[0038] Method 2.1: (1) Dissolve 1.25g SH (average molecular weight 1.2 million Daltons) in 50ml distilled water, add ADH 125mg and ethyl (N,N-dimethylaminopropyl) carbodiimide (EDCI) 0.3g, add 0.5mol / L hydrochloric acid solution dropwise to adjust the pH value to 6.0, stir for 4 hours, add an equal volume of PBS with 2 times the isotonic concentration and soak for 4 hours, then purify with isotonic PBS for 4-6 hours, and break to obtain gel particles. (2) Add 0.05g of HAP (average particle size: 10-100μm) and mix evenly, and sterilize with circulating steam at 100°C for 30 minutes to obtain the product.
[0039] Method 2.2: (1) Obtain gel particles according to step (1) in method 2.1. (2) Add 10 g of HAP (average particle size 0.1-10 μm), mix well, and sterilize at 121° C. for 15 minutes to obtain the product.
[0040] Method 2.3: (1) Diss...
Embodiment 3
[0047] Composite biomaterial composed of divinyl sulfone (DVS) cross-linked cHA gel and HAP. The preparation method is as follows:
[0048] Method 3.1: (1) Mix 1g SH (average molecular weight 1,000,000 Daltons) and 0.25g HAP (average particle size 100-500μm), mix with 25ml of 1% NaOH solution containing 0.2g DVS, and store at 25°C After reacting for 1 hour, add 25ml of distilled water and let it stand at 25°C for 8-12 hours to obtain block gel. (2) Freeze-dry the bulk gel for 6-12 hours, purify it with physiological saline for 10 hours, dehydrate it with ethanol, dry it under reduced pressure, cut or crush it, and sterilize it with ethylene oxide to obtain the product.
[0049] Method 3.2: (1) According to the step (1) in method 3.1 to obtain block gel. (2) Purify the block gel with 50% to 70% ethanol for 4 to 12 hours, dehydrate with absolute ethanol, dry under reduced pressure, cut or crush, and sterilize with ethylene oxide to obtain the product.
[0050] Method 3.3: (1)...
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