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Method for preparing graphene oxide-chitosan composite material

A composite material, chitosan technology, applied in medical science, prosthesis, etc., can solve the problems of high cost and complex processing, and achieve the effects of uniform properties, increased interface bonding force, and orderly arrangement

Active Publication Date: 2016-12-14
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Another object of the present invention is to overcome the defects of high cost, complex processing, mechanical properties and other aspects of existing osteoinductive materials, and provide a novel graphene oxide-chitosan composite material with interfacial bonding, The remarkable feature of this composite material is to activate the carboxyl functional groups on graphene oxide, so that the activated carboxyl graphene oxide reacts with chitosan, cross-links and generates amide bonds, thus endowing graphene oxide-chitosan The strong interfacial bonding of the sugar composite material greatly improves the mechanical properties of the cross-linked composite material compared with the composite material without cross-linking, realizing its use in osteoinductive technology

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0031] A preparation method of graphene oxide-chitosan composite material, comprising the following steps:

[0032] Step 1, get the chitosan solid powder and place it in an oven for drying, sieve to remove impurities, then add a 2% acetic acid solution by volume fraction to prepare a 2% chitosan solution by mass fraction;

[0033]Step 2, take the dried graphene oxide solid and dissolve it in ultra-pure water, ultrasonically for 2 hours, to obtain a graphene oxide solution with a mass fraction of 1% evenly dispersed; while stirring, add the graphene oxide solution with a concentration of 0.03mmol / L of 1-ethyl-(3-dimethylaminopropyl) carbodiimide solution, after the dropwise addition was completed, stirred and reacted for 10min, and then the nitrogen-hydroxysuccinic acid imide solution with a concentration of 0.06mmol / L Add dropwise in the graphene oxide solution, stir and react for 1 hour to obtain the graphene oxide solution of the activated carboxyl group; the volume of the g...

Embodiment 2

[0036] A preparation method of graphene oxide-dopamine composite material, comprising the following steps:

[0037] Step 1. Take the dopamine solid powder and place it in an oven for drying, sieve to remove impurities, and then add deionized water to prepare a dopamine solution with a mass fraction of 2%.

[0038] Step 2, take the dried graphene oxide solid and dissolve it in ultra-pure water, ultrasonically for 2 hours, to obtain a graphene oxide solution with a mass fraction of 1% evenly dispersed; while stirring, add the graphene oxide solution with a concentration of 0.03mmol / L of 1-ethyl-(3-dimethylaminopropyl) carbodiimide solution, after the dropwise addition was completed, stirred and reacted for 10min, and then the nitrogen-hydroxysuccinic acid imide solution with a concentration of 0.06mmol / L Add dropwise in the graphene oxide solution, stir and react for 1 hour to obtain the graphene oxide solution of the activated carboxyl group; the volume of the graphene oxide so...

Embodiment 3

[0041] A preparation method of nucleic acid-carrier protein composite material, comprising the following steps:

[0042] Step 1, adding the carrier protein into deionized water to prepare a carrier protein solution with a mass fraction of 2%;

[0043] Step 2, adding nucleic acid into ultrapure water, stirring to obtain a uniformly dispersed mass fraction of 1% nucleic acid solution; while stirring, adding dropwise 1-ethyl-(3- Dimethylaminopropyl) carbodiimide solution, stirred and reacted for 10 minutes after the dropwise addition was completed, then added the nitrogen-hydroxysuccinimide solution with a concentration of 0.06mmol / L dropwise into the nucleic acid solution, stirred and reacted for 1 hour, and activated The nucleic acid solution of carboxyl; the volume ratio of described nucleic acid solution and 1-ethyl-(3-dimethylaminopropyl) carbodiimide solution is 1:0.5; The volume of nucleic acid solution and nitrogen-hydroxysuccinic acid imide solution Ratio 1:0.1;

[004...

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Abstract

The invention discloses a method for preparing a graphene oxide-chitosan composite material. The method includes the steps that a chitosan solution is prepared; secondly, a graphene oxide solution is prepared, a 1-ethyl-(3-dimethylaminopropyl)carbodiimide (EDC) solution is added into the graphene oxide solution during stirring, stirring reaction is conducted after dropwise addition, then an N-hydroxyl succinimide (NHS) solution is dropwise added into the graphene oxide solution, stirring reaction is conducted, and an activated hydroxyl graphene oxide solution is obtained; thirdly, the activated hydroxyl graphene oxide solution is dropwise added into the chitosan solution and stirred, the mixture is poured into a mould after being cooled to room temperature, and the cross-linked graphene oxide-chitosan composite material is obtained after freezing drying. The novel graphene oxide-chitosan composite material having an interface bonding function is provided, compared with non-cross-linked composite materials, mechanical properties of the composite material are greatly improved, and use of the composite material in the aspect of the bone induction technology is achieved.

Description

technical field [0001] The invention belongs to the field of composite material preparation, and in particular relates to a preparation method of graphene oxide-chitosan composite material. Background technique [0002] Osteoinduction is an important medical technology in the medical field. Nowadays, many osteoinductive materials have been used in clinical operations, but their use is limited due to their weak mechanical properties. Therefore, it is necessary to find a composite material with strong mechanical properties to make up for the shortage of existing osteoinductive materials and expand its wide use. [0003] In the field of biomedicine, graphene and its derivative graphene oxide have attracted more and more attention due to their own unique properties. The main part of graphene oxide is a two-dimensional structure composed of stable six-membered rings, which has certain At the same time, the surface and edge of its two-dimensional structure contain a large number ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/08A61L27/22A61L27/50
Inventor 张红平丁剑平陈盼盼罗学刚林晓艳周建张永德张亚萍
Owner SOUTHWEAT UNIV OF SCI & TECH
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