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Traditional Chinese drop pills for treating cardiovascular and cerebrovascular diseases and preparation method thereof

A technology of cardiovascular and cerebrovascular and drop pills, which is applied in the field of traditional Chinese medicine, can solve the problems of low bioavailability, low degree of automation, and slow absorption, and achieve the effect of fast dissolution, high degree of automation, and rapid absorption

Active Publication Date: 2011-09-28
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the capsules prepared according to this standard have the disadvantages of low preparation process automation, slow absorption, slow onset of action, and low bioavailability. It is very necessary to take sublingual traditional Chinese medicine drop pills in case of emergency

Method used

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  • Traditional Chinese drop pills for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Traditional Chinese drop pills for treating cardiovascular and cerebrovascular diseases and preparation method thereof
  • Traditional Chinese drop pills for treating cardiovascular and cerebrovascular diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] [embodiment 1] the preparation of dropping pill

[0094] Take 40g of salvia miltiorrhiza, 30g of red peony root, 30g of Polygonum multiflorum, 30g of medlar, 30g of kudzu root, 30g of chuanxiong, 20g of safflower, 30g of Alisma, 30g of Achyranthes bidentata, 30g of earthworm, 3g of turmeric, 30g of polygala (honey-roasted), 9g Iris 30g, jujube seed (fried) 20g, deer heart powder 30g, licorice 20g, the above sixteen flavors, except deer heart powder, Chuanxiong, safflower, Alisma, Achyranthes bidentata, turmeric, polygala, calamus nine knots, The jujube seed and licorice are crushed to 150 mesh and set aside. For the remaining 6 flavors such as Salvia miltiorrhiza, add 4 times the amount of water to decoct for 2 hours using the dynamic countercurrent extraction method, filter, and concentrate the filtrate into a thick paste. Add the above-mentioned thick ointment, drug fine powder and deer heart powder into molten polyethylene glycol 4000 in a ratio of 4:7, mix evenly, ...

Embodiment 2

[0095] [embodiment 2] the preparation of dropping pill

[0096] Take 40g of salvia miltiorrhiza, 30g of red peony root, 30g of Polygonum multiflorum, 30g of medlar, 30g of kudzu root, 30g of chuanxiong, 20g of safflower, 30g of Alisma, 30g of Achyranthes bidentata, 30g of earthworm, 3g of turmeric, 30g of polygala (honey-roasted), 9g Iris 30g, jujube seed (fried) 20g, deer heart powder 30g, licorice 20g, the above sixteen flavors, except deer heart powder, Chuanxiong, safflower, Alisma, Achyranthes bidentata, turmeric, polygala, calamus nine knots, The jujube seed and licorice are crushed to 120 mesh and set aside. Add the remaining 6 flavors of Salvia miltiorrhiza, add water and decoct three times, the first time for 3 hours, the second time for 2 hours, and the third time for 1 hour, combine the decoction, filter, and concentrate the filtrate into a thick paste. Add the above-mentioned thick ointment, drug fine powder and deer heart powder into molten polyethylene glycol 40...

Embodiment 3

[0097] [embodiment 3] the preparation of dropping pill

[0098] Take 40g of salvia miltiorrhiza, 30g of red peony root, 30g of Polygonum multiflorum, 30g of medlar, 30g of kudzu root, 30g of chuanxiong, 20g of safflower, 30g of Alisma, 30g of Achyranthes bidentata, 30g of earthworm, 3g of turmeric, 30g of polygala (honey-roasted), 9g Iris 30g, jujube seed (fried) 20g, deer heart powder 30g, licorice 20g, the above sixteen flavors, except deer heart powder, Chuanxiong, safflower, Alisma, Achyranthes bidentata, turmeric, polygala, calamus nine knots, The jujube seed and licorice are crushed to 150 mesh and set aside. For the remaining 6 flavors such as Salvia miltiorrhiza, add 6 times the amount of water to decoct for 1 hour using the dynamic countercurrent extraction method, filter, and concentrate the filtrate into a thick paste. Add the above-mentioned thick ointment, drug fine powder and deer heart powder into molten polyethylene glycol 6000 in a ratio of 4:7, mix evenly, kee...

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PUM

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Abstract

The invention discloses a new form of a traditional Chinese medicine compound and a preparation method thereof. The new form of traditional Chinese medicine compound is used for activating the circulation of blood, dissolving the blood stasis, promoting the restoration of consciousness, taking away the pain, dilating the blood vessel, increasing the coronary artery blood flow and treating the coronary heart disease and the cerebral arteriosclerosis. The preparation method of the traditional Chinese drop pills comprises the following steps: grinding szechuan lovage rhizome, safflower, alisma orientale, achyranthes, radix curcumae, polygala tenuifolia, rhizoma anemones altaicae, spina date seeds and liquorice powder into medical fine power of 150 mesh for later use; adding water to decoct aalvia miltiorrhiza, red paeony root, prepared radix polygoni multiflori, barbary wolfberry fruit, kudzu-vine root and earthworm for 2 hours with a dynamic counter current extraction method, wherein the water is four times the total amount of the aalvia miltiorrhiza, the red paeony root, the prepared radix polygoni multiflori, the barbary wolfberry fruit, the kudzu-vine root and the earthworm; filtering the decoction; concentrating the filtered decoction into thick paste; adding and evenly stirring the thick paste, the medical fine power and dear heart powder to molten polyethylene glycol 4000,wherein the proportion of the thick paste, the medical fine power and the dear heart powder to the molten polyethylene glycol 4000 is 4:7; uniformly mixing; keeping the temperature of the mixture at 70 DEG C; dripping the mixture into liquid paraffin at constant speed; leaching the prepared traditional Chinese drop pills and wiping out the liquid paraffin. Test proves that the traditional Chinesedrop pills are more markedly improved in the curative effect and the bioavailability than the original capsules.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine drop pill for treating cardiovascular and cerebrovascular diseases and a product thereof, belonging to the technical field of traditional Chinese medicine. Background technique [0002] With the improvement of social living standards and the aging of the population, the incidence of cardiovascular diseases shows an upward trend. Especially coronary heart disease, angina pectoris and cerebral arteriosclerosis have seriously threatened the health of middle-aged and elderly people, affecting the normal life of many middle-aged and elderly people, and also brought a lot of misery to families. [0003] Due to the large number of patients with this disease, the long course of the disease, and the low cure rate, there are many drugs used to treat this type of disease, and the therapeutic effects are also uneven, and most of the drugs are expensive, so choose one that has a definit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61K36/9066A61K47/34A61K47/12A61K47/42A61K9/20A61K35/34A61P9/10A61K35/62A61K47/10
Inventor 付立家付建家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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