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Traditional Chinese medicine combination for treating leukemia and preparation method thereof

A composition, leukemia technology, applied in the direction of drug combination, pharmaceutical formula, medical preparation containing active ingredients, etc.

Active Publication Date: 2009-12-02
INCREASEPHARM (ZHUHAI) PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there is no unified basis for syndrome differentiation, the general trend of syndrome differentiation in traditional Chinese medicine is still mainly the deficiency of both qi and yin, the deficiency of both qi and blood, the accumulation of heat and toxin, and the stagnation of blood stasis.

Method used

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  • Traditional Chinese medicine combination for treating leukemia and preparation method thereof
  • Traditional Chinese medicine combination for treating leukemia and preparation method thereof
  • Traditional Chinese medicine combination for treating leukemia and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Realgar 0.08kg, Qingdai 2kg, Angelica 9kg, Chuanxiong 6kg

[0043] Add 5 times the amount of water to Angelica and Chuanxiong, decoct for 2 hours, filter, add 4 times the amount of water to the filter residue, decoct for 1 hour, filter, discard the filter residue, combine the filtrates twice, concentrate the filtrate under reduced pressure to 15L, add ethanol to make The alcohol concentration of the medicinal solution is 70%, let it stand, filter, concentrate to a thick paste with a relative density of 1.30-1.35 (50°C), dry under reduced pressure (60°C, -0.08Mpa), and obtain the extracts of Angelica sinensis and Rhizoma Chuanxiong ;

[0044] Heat and melt 20kg polyethylene glycol 4000 and 8kg polyethylene glycol 6000, add angelica, chuanxiong extract, realgar, and Qingdai fine powder, mix well, keep warm at 60-80°C, drop into the cooled simethicone, wait After the dropping pills are cooled, take them out, drain and wipe off the simethicone oil to obtain the dropping pi...

Embodiment 2

[0046] Realgar 0.05kg, Qingdai 2kg, Angelica 12kg, Chuanxiong 6kg

[0047] Add 5 times the amount of water to angelica and chuanxiong, decoct for 2 hours, filter, add 4 times the amount of water to the filter residue, decoct for 1 hour, filter, discard the filter residue, combine the filtrates twice, concentrate the filtrate under reduced pressure to 18L, add ethanol to make The alcohol concentration of the medicinal solution is 70%, let it stand, filter, concentrate to a thick paste with a relative density of 1.30-1.35 (50°C), dry under reduced pressure (60°C, -0.08Mpa), and obtain the extracts of Angelica sinensis and Rhizoma Chuanxiong ;

[0048] Crush angelica, chuanxiong extract, realgar, and Qingdai into fine powder, add appropriate amount of honey, mix well, and make pills.

Embodiment 3

[0050] Realgar 0.1kg, Qingdai 2kg, Angelica 9kg, Chuanxiong 6kg

[0051] Soak Angelica and Rhizoma Chuanxiong in water for 4 hours, use a volatile oil extractor to use petroleum ether (30, -60°C) as a solvent, and distill with water for 6 hours, collect the volatile oil, evaporate the petroleum ether at 60°C to obtain volatile oil, and wrap it with beta cyclodextrin Combined to make beta cyclodextrin inclusion complex; filter the residue after distillation to obtain filtrate 1, add 70% ethanol to the dregs, reflux extraction for 1.5 hours and then filter to obtain filtrate 2, combine the filtrates twice, and concentrate To a thick paste with a relative density of 1.30-1.35 (50°C), dry under reduced pressure (60°C, -0.08Mpa), pulverize, add beta-cyclodextrin inclusion compound, and obtain Angelica and Chuanxiong extracts;

[0052] Grind angelica, chuanxiong extract, realgar, and Qingdai into fine powder, add 15kg of lactose, mix well, granulate with 95% ethanol, dry, and pack i...

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Abstract

The invention discloses a traditional Chinese medicine combination for treating leukemia and a preparation method thereof. The combination is prepared by realgar, indigo naturalis, angelica and ligusticum wallichii according to a certain weight proportioning. The combination can be prepared into any kind of usual dosage form. The traditional Chinese medicine combination of the invention has the functions of clearing heat, detoxicating and invigorating blood circulation and is applied to treating various chronic and acute leukemias.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating leukemia and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Leukemia is a malignant disease of blood-forming tissues. It is characterized by the unlimited proliferation of a large number of leukemia cells in the bone marrow and other hematopoietic tissues, and enters the peripheral blood, while the production of normal blood cells is significantly inhibited. Viruses may be the main pathogenic factor, but there are many factors such as radiation, chemical poisons (benzene, etc.) or drugs, genetic quality, etc. may be pathogenic cofactors. According to the degree of immaturity of leukemia cells and the natural course of leukemia, it is divided into two categories: acute and chronic. According to the type of proliferating cells, it can be divided into three types: granulocytic, lymphocytic and monocytic. ...

Claims

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Application Information

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IPC IPC(8): A61K36/315A61K36/70A61K9/20A61K9/48A61P35/02A61K33/36
Inventor 胡杰
Owner INCREASEPHARM (ZHUHAI) PHARM CO LTD
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