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Preparation for new antivirus Chinese medicine formulation for animal

An antiviral and traditional Chinese medicine technology, applied in the field of traditional Chinese veterinary medicine, can solve the problems of insufficient therapeutic effect, low bioavailability, extraction and concentration, etc., and achieve the effects of improved clinical efficacy, improved bioavailability, and stable preparations

Active Publication Date: 2009-11-25
BEIJING DABEINONG ANIMAL HEALTH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the veterinary preparations composed of the above traditional Chinese medicines sold on the market all adopt the traditional processing technology, that is, simple crushing and mixing. This process does not extract and concentrate the active ingredients of the raw materials during the processing process, and does not carry out special treatment on the volatile oil components. , the bioavailability is low, the absorption is poor after feeding the mixture, the effect is slow, and the ideal therapeutic effect cannot be achieved; in use, some users first soak the medicinal hot water and then drink the medicinal liquid for livestock and poultry, the effect is better than Direct feeding is slightly better, but it is very troublesome to apply

Method used

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  • Preparation for new antivirus Chinese medicine formulation for animal
  • Preparation for new antivirus Chinese medicine formulation for animal
  • Preparation for new antivirus Chinese medicine formulation for animal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Steam distillation to extract volatile oil Take 4500g Nepeta chinensis, 3000g Bupleurum chinensis, 2500g Chuanxiong, 1500g mint and 2500g notopterygium, crush them separately, pass through a 30-mesh sieve, soak in water for 0.5 hours, heat and reflux for 1 hour, distill under reduced pressure, collect The initial liquid of 3 times the weight of the medicinal materials was re-distilled, and the rectified liquid of 1 times the weight of the medicinal materials was collected, refrigerated for 12 hours, filtered, and the volatile oils of Schizonepeta, Bupleurum, Chuanxiong and Mentha were obtained, and the medicinal residues were stored in a separate container for later use. Store the cooking water for later use;

[0036] (2) Take 3000g of Fangfeng, 2500g of Duhuo, 2500g of Peucedanum, 3000g of Citrus aurantium, and 3000g of Platycodon grandiflora, and grind them into coarse powder and add the dregs obtained in (1), extract 3 times with 95% ethanol, and collect the extra...

Embodiment 2

[0045](1) Extract volatile oil by supercritical extraction method, take 4500g Nepeta chinensis, 3000g Bupleurum chinensis, 2500g Rhizoma Chuanxiong, 1500g mint and 2500g notopterygium, grind them separately, pass through a 30 mesh sieve, and carry out supercritical fluid extraction, control the pressure at 7Ma and the temperature at 45 ℃, cyclic extraction for 3 hours, the volatile oils of Schizonepeta, Bupleurum, Chuanxiong and Peppermint are obtained; the dregs of the medicine are stored in a separate container for later use, and the boiling water is kept for later use;

[0046] (2) Take 3000g of Fangfeng, 2500g of Duhuo, 2500g of Peucedanum, 3000g of Citrus aurantium, and 3000g of Platycodon grandiflorum, and grind them into coarse powder, add (1) dregs at the same time, extract them with 60% ethanol for 3 times, collect the extract to recover ethanol When the density reaches 1.1, the ethanol extract is obtained for future use, and the dregs are stored in another device for ...

Embodiment 3

[0055] (1) The volatile oil is extracted by microwave method. Take 4500g of Nepeta chinensis, 3000g of Bupleurum chinensis, 2500g of Rhizoma chuanxiong, 1500g of mint and 2500g of notopterygium, pulverize them respectively, pass through a 30-mesh sieve, add warm water for 2 hours, and place in a continuous microwave reactor for extraction. The power is 500W, and the time is 30 minutes. The volatile oils of nepeta, bupleurum, chuanxiong and mint are obtained.

[0056] (2) Take 3000g of Fangfeng, 2500g of Duhuo, 2500g of Peucedanum, 3000g of Citrus aurantium, and 3000g of Platycodon grandiflorum, and grind them into coarse powder and add (1) medicinal residues, extract 3 times with 60% ethanol, collect the extract and recycle the ethanol to When the density reaches 1.1, the ethanol extract is obtained for future use, and the dregs are stored in another device for future use;

[0057] (3) Get 4,500 g of Poria cocos and 1,500 g of licorice, and grind them into coarse powder, soak ...

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Abstract

The invention provides a preparation for a new antivirus Chinese medicine formulation for the animal, belonging to the field of the Chinese medicine for animal. The preparation of the invention includes: the volatile oil ingredients in schizonepeta tenuifolia, radix bupleuri, ligusticum wallichii, dried peppermint herb and notopterygium root in the formulation are extracted out, and solidified by the inclusion technology, the other effective ingredients in the above Chinese medicines are extracted out, and the effective ingredients of the other components in the formulation, such as ledebouriella root, pubescent angelica root, hogfennel root, bitter orange, poria cocos wolf, root of balloonflower and glycyrrhiza, are extracted out, at last, the obtained extracts are made into powder, granula or premix, also made into feedstuff premix adding into feedstuff, the clinical trial proves that the new formulation prepared by the method of the invention has improved stability, decreased dose and easy use, because the effective ingredients have increased dissolution rate, the effect is fast, the pharmacological effect is lasting and the bioavailability and the clinical treating effect are greatly improved.

Description

technical field [0001] The invention relates to a preparation method of a novel antiviral traditional Chinese medicine preparation for veterinary use, and belongs to the field of traditional Chinese veterinary medicine. Background technique [0002] The prescription of this new veterinary antiviral traditional Chinese medicine preparation comes from Jingfangbaidu Powder, page 457, Part Two, 2005 edition of Veterinary Pharmacopoeia of the People's Republic of China. The whole prescription of Jingfangbaidu Powder is composed of 12 traditional Chinese medicines including Schizonepetae, Fangfeng, Notopterygium, Duhuo, Bupleurum, Peucedanum, Citrus aurantium, Poria, Campanulaceae, Chuanxiong, Licorice, and Mint. Dispelling dampness, heat-clearing and toxic substances removing, strengthening vital energy and eliminating pathogenic factors. Clinically used for livestock and poultry viral diseases such as: swine influenza, porcine circovirus type II infection, blue ear disease, por...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/538A61P31/12A23K1/16A23K10/30A23K40/10
Inventor 邓利斌秦玉明冯华兵杜继红莫云刘澜葛冰田玲丛日刚葛代兴黄建茹
Owner BEIJING DABEINONG ANIMAL HEALTH TECH
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