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Surface treatment method of tissue-engineered bioactive implant

A biologically active and tissue engineering technology, applied in prosthetics, medical science, etc., can solve problems such as osseointegration, easy vascularization of bone tissue, etc., achieve the effect of solving low success rate and expanding the scope of application

Inactive Publication Date: 2010-09-01
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
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Problems solved by technology

[0003] The purpose of the present invention is to provide a surface treatment method for tissue-engineered bioactive implants, which can replace implant processing for special patients, so that implants can obtain osseointegration in special implant areas, and solve the problem of implant placement in hosts. The problem of easy vascularization and osseointegration of bone tissue in the region lays the foundation for the later restoration of implant dentures and maxillofacial defects

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  • Surface treatment method of tissue-engineered bioactive implant
  • Surface treatment method of tissue-engineered bioactive implant
  • Surface treatment method of tissue-engineered bioactive implant

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Embodiment Construction

[0022] The present invention will be further described below in conjunction with specific examples. It should be understood that the following examples are only used to illustrate the present invention and are not intended to limit the implementation scope of the present invention.

[0023] The method for treating the surface of the tissue engineered bioactive implant of the present invention comprises the following steps:

[0024] (1) Obtain bone marrow stromal stem cells BMMSCs from autologous ilium, or obtain periodontal ligament stem cells PDLSCs from extracted fresh healthy teeth;

[0025] (2) Put bone marrow stromal stem cells BMMSc or periodontal ligament stem cells PDLSCs into culture dish 1 added with α-MEM medium 2, add bone marrow stromal stem cells BMMSc or periodontal ligament stem cells PDLSCs culture dish 1 to promote extracellular secretion stromal factor 4, perform in vitro stratified growth of bone marrow stromal stem cells or periodontal ligament stem cells,...

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Abstract

A surface treatment method of a tissue-engineered bioactive implant comprises the following steps of: (1) obtaining marrow stromal cells from autologous ilium or obtaining periodontal ligament stem cells from a fresh healthy tooth which is pulled off; (2) putting the marrow stromal cells or the periodontal ligament stem cells into a culture dish in which Alpha-MEM culture medium is added, and adding factors promoting the secretion of extracellular matrix into the marrow stromal cells or the periodontal ligament stem cells so as to form marrow stromal cell aggregate or periodontal ligament stemcell aggregate; (3) wrapping an implant with the marrow stromal cell aggregate or the periodontal ligament stem cell aggregate; (4) placing the wrapped implant in the culture medium; and (5) adding vitamin C and hexadecadrol into the culture medium to promote the secretion of the extracellular matrix, thereby causing the marrow stromal cell aggregate or the periodontal ligament stem cell aggregate together with the implant to form tissue-engineered implant with bioactivity. The surface treatment method solves the problem that patients suffering from osteoporosis and diabetes and recovering from radiation treatment have low implant success rate.

Description

technical field [0001] The invention relates to a medical method for a craniomaxillofacial implant, in particular to a method for treating the surface of a tissue engineered bioactive implant. Background technique [0002] Pluripotent stem cells with multidirectional differentiation and tissue regeneration capabilities, as seed cells for tissue engineering, have achieved good results in promoting tissue repair and treating systemic diseases, and have gradually been widely used and developed. Cell aggregate technology is a new technology for constructing regenerative tissue using seed cells in tissue engineering. Using this technology, a large number of seed cells can be compounded on suitable scaffold materials to construct tissue engineered tissues in vitro. At present, the existing craniofacial implants mainly include titanium, titanium alloy and zirconium ceramic materials, which are processed by surface physics (acid-etching sandblasting), chemical (micro-arc oxidation) ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/38
Inventor 赵铱民周炜宋应亮冯雪
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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