Biodegradable compound powder-style hemostasis material

Abstract

The invention belongs to the technical field of medicine and particularly relates to a biodegradable compound powder-style hemostasis material composed of cross-linked porous corn starch and chitosan / alginic acid compound microballoon. The chitosan adopted by the hitosan / alginic acid compound microballoon can be carboxymethyl chitosan or a compound of a plurality of chitosan with different degrees of deacetylation and different molecular weights, or can be multiaperture chitosan microballoon or other derivatives of chitosan. The cross-linked porous corn starch can be prepared by one or at least two types of the following materials: sweet potate starch, potato starch, cassava starch, corn starch, rice starch, long-shaped rice starch, sago starch, mung bean starch, wheat starch, water caltrop starch, lotus-root starch, sorghum starch and radix puerariae starch, or can be prepared by etherified modified starch or etherified and cross-linked compound modified starch. The biodegradable compound powder-style hemostasis material provided by the invention has simple and convenient preparation process, low cost, quick hemostasis effect and good performance.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a biodegradable high-efficiency compound powder hemostatic material. Background technique [0002] Hemorrhage is not only the first cause of death from war injuries, but also the second cause of death from trauma, and it is also the main cause of death in operating room patients. The treatment of hemorrhage in solid organ wounds is a difficult problem for surgeons. [0003] At present, commonly used hemostatic materials include oxidized cellulose and oxidized regenerated cellulose, collagen material preparations, chitosan and its derivative materials, fibrin glue, gelatin sponge and gelatin fiber mesh, alginate materials and microporous polysaccharides for hemostasis ball. Various animal experiments and clinical applications have been fully affirmed, but different hemostatic materials have different hemostatic mechanisms, as well as the corresponding advantages and limitations...

AI Technical Summary

Problems solved by technology

However, it also has defects: first, the starch granules are small and light, and when sprayed on the bleeding wound, they often float on the surface of the bleeding blood flow, so when using it, the doctor needs to press the hemostatic powder on the wound; second, its hemostatic powder When encountering blood, it often undergoes denaturation, starch itself coalesces, and it is difficult to penetrate into the bleeding site; especially for active bleeding, it is difficult to achieve the purpose of hemostasis; Chlorohydrins are used as cross-linking agents; Fourth, the price is expensive

This seriously affects its hemostatic properties

[0006] At present, there is no powder hemostatic material in China that has a fast onset of hemostatic effect, good adhesion to the wound surface, a certain penetration ability, and a certain promotion effect on wound healing, and is reasonably priced.