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Aftosa vaccine immunopotentiator

An immune enhancer and foot-and-mouth disease vaccine technology, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of low protection rate, large side effects, and short protection period of foot-and-mouth disease vaccines, and achieve the effects of eliminating toxic and side effects, convenient use, and clearing intracellular infection viruses

Inactive Publication Date: 2009-10-14
BEIJING UNIV OF AGRI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The object of the present invention is to provide a kind of foot-and-mouth disease vaccine immunopotentiator, containing chondroitin sulfate, astragalus polysaccharide, ginsenoside Rb1 in this immunopotentiator; Make the body produce the expected immune response, and solve the shortcomings of the existing foot-and-mouth disease vaccines, such as short protection period, low protection rate and large side effects

Method used

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  • Aftosa vaccine immunopotentiator
  • Aftosa vaccine immunopotentiator
  • Aftosa vaccine immunopotentiator

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of foot-and-mouth disease vaccine immunostimulant is characterized in that, contains in this enhancer: astragalus polysaccharide, chondroitin sulfate, ginsenoside Rb1, danshensu; The weight ratio of each component in this enhancer is:

[0026] Astragalus polysaccharide 4-40, chondroitin sulfate 4-40, ginsenoside Rb1 1-20,

[0027] Danshensu 1-20;

[0028] The weight unit used in this embodiment is microgram, also can be milligram, also can be gram.

[0029] The astragalus polysaccharides, chondroitin sulfate, ginsenoside Rb1, and danshensu described in this example all have a purity of more than 95%, and were all purchased from Nanjing Zelang Pharmaceutical Technology Co., Ltd.

[0030] The vaccine with the enhancer effect described in this example is the foot-and-mouth disease type O-Asia I bivalent inactivated vaccine, purchased from China Animal Husbandry Industry Co., Ltd. (an enterprise that has passed the GMP inspection of veterinary drugs, and the veterin...

Embodiment 2

[0033] The present embodiment is a preferred scheme based on embodiment 1, and the quality of raw materials (components) used is the same as that of embodiment 1, and the weight ratio of each component in the described foot-and-mouth disease vaccine immunostimulant is:

[0034] Astragalus polysaccharide 5, chondroitin sulfate 5, ginsenoside Rb1 2, danshensu 2;

[0035] The weight unit used in this embodiment is microgram, also can be milligram, also can be gram.

[0036] Following test is to detect the drug effect of described foot-and-mouth disease vaccine immunostimulant:

[0037] Among them, the conclusion of Experiment 1 provides a theoretical basis for Experiment 2. Described test 1 illustrates that described foot-and-mouth disease vaccine immunopotentiator can increase the expression of interferon-γ (IFN-γ) in neonatal rat myocardium microvascular endothelial cells (Rat Myocardial Microvascular Endothelial Cells, RMMVECs), has the effect of enhancing immunity The resul...

Embodiment 3

[0103] The present embodiment is the preferred scheme based on embodiment 1, and the quality of raw material (component) used is identical with embodiment 1, and the weight ratio of each component is in the described foot-and-mouth disease vaccine immune enhancer:

[0104] Astragalus polysaccharide 25, chondroitin sulfate 25, ginsenoside Rb1 13, danshensu 13;

[0105] The weight unit used in this embodiment is microgram, also can be milligram, also can be gram.

[0106] Following test is to detect the drug effect of described foot-and-mouth disease vaccine immunostimulant:

[0107] Animal test: the described foot-and-mouth disease vaccine immunopotentiator acts on mice, and detects the titer of foot-and-mouth disease vaccine in mouse serum by ELISA method;

[0108] The specific operation steps, test animals, reagent parameters, etc. are the same as those in "Test 2" in Example 2;

[0109] Table 7: The concentration (ug / ml) of the foot-and-mouth disease vaccine immunopotentia...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations and particularly relates to an aftosa vaccine immunopotentiator. The immunopotentiator contains astragalus polyose, chondroitin sulfate, ginsenoside Rb1 and Salvianic acid A and the weight ratio of all the components is 4-40:4-40:1-20:1-20. The immunopotentiator has the function of inducing the increase of microvascular endothelial cell interferons. Proved by experimental animals, the immunopotentiator has the function of remarkably improving the titer of aftosa vaccines after first immunization, and can lead the titer of more than 80 percent of immune animal antibodies to meet standards after the existing aftosa vaccines are first used for immunization. Being a compound of traditional Chinese medicine ingredients, the immunopotentiator can eliminate the toxic and side effects of the existing aftosa vaccines and is also convenient for use.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a foot-and-mouth disease vaccine immune enhancer, which contains astragalus polysaccharide, chondroitin sulfate, ginsenoside Rb1 and danshensu. Background technique [0002] Foot and mouth disease (FMD) is an acute, febrile and highly contagious infectious disease of artiodactyla animals caused by Foot-and-Mouth Disease Virus (FMDV), known as "political and economic disease". At present, the disease is prevalent and occurs in many countries and regions in the world, which seriously threatens the development of animal husbandry in all countries in the world and causes huge economic losses. In addition to the direct economic loss caused by the death of animals, the disease caused a decline in meat and milk production during the disease period, a long-term reduction in meat and milk production and loss of seed value after the disease, resulting in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/39A61P31/14A61K39/135
Inventor 穆祥张涛胡格索占伟段慧琴董虹徐巨袁希民王庆波
Owner BEIJING UNIV OF AGRI
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