Antimycotic patch
A technology of patch and adhesive layer, applied in the field of percutaneous absorption type patch, can solve the problems of easy change of adhesion characteristics, skin irritation, inability to meet drug transfer, etc., and achieve the effect of preventing rapid changes in storage temperature
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Embodiment 1
[0079] A patch was prepared according to the following composition and production method.
[0080] 1. Terbinafine *1 20.0%
[0081] 2. Acrylic adhesive *2 79.7% (solid content)
[0082] 3. Polyisocyanate *3 0.3%
[0083] *1 : Purchased from KANEDA Co., Ltd.
[0084] *2 : Obtained by conventional solution polymerization of 96% 2-ethylhexyl acrylate and 4% acrylic acid at a concentration of 33% in ethyl acetate using 0.5 parts of polymerization initiator lauroyl peroxide. Hereinafter, the numerical value of the adhesive represents the solid content.
[0085] *3 : Coronate HL (Japan Polyurethane Industry Co., Ltd.)
[0086] (Manufacturing method) After weighing the above-mentioned components, the overall solid content was adjusted to 25% in ethyl acetate, and stirred until uniform. Coating was carried out on a 75 μm single-sided silicone-treated PET (polyethylene terephthalate) film (Filmbyna 75E-0010 No.23, Fujimori Industry Co., Ltd.) so that the thickness of...
Embodiment 7
[0094] Terbinafine was 10.0%, a silicone-based adhesive was used as a base, and a patch was prepared using the following composition table and production method.
[0095] 1. Terbinafine *1 10.0%
[0096] 2. Silicone adhesive *4 90.0%
[0097] *1 : Same as
[0098] *4 : BIO-PSA4501 (Dow Corning)
[0099] Combine polydimethylsiloxane with MQ resin (by M unit ((CH 3 ) 3 SiO 1 / 2 ) and Q units (SiO 2 ) Formed branched polysiloxane) with a composition ratio of 60:40 (mass ratio), obtained by polymerization at a concentration of 63% in heptane by a conventional solution polymerization method. Hereinafter, the numerical value of the adhesive represents the solid content.
[0100] (Manufacturing method) After weighing the above ingredients, stir until uniform. Coating was carried out on a 75 μm single-sided silicone-treated PET (polyethylene terephthalate) film (Filmbyna 161-8066FN-75, Fujimori Kogyo Co., Ltd.) so that the thickness of the adhesive layer at the time ...
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