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Antimycotic patch

A technology of patch and adhesive layer, applied in the field of percutaneous absorption type patch, can solve the problems of easy change of adhesion characteristics, skin irritation, inability to meet drug transfer, etc., and achieve the effect of preventing rapid changes in storage temperature

Inactive Publication Date: 2009-09-23
NICHIBAN KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most drugs lack skin penetration by themselves and often must be formulated with penetration enhancers
Moreover, although the penetration enhancer is combined to improve the transferability of the drug to the nail, it cannot satisfy the transfer of the drug to the nail bed side.
[0012] On the other hand, the above-mentioned preparation using a dissolving agent is not developed as a preparation that can be applied on the nails for the purpose of treating and / or preventing onychomycosis because its main goal is to stick to the skin. did not solve the above problems
[0013] In addition, the treatment of onychomycosis carried out by local administration has the following disadvantages: the penetration of the drug to the thick hard keratin layer, that is, the nail plate, is hindered, and the medicament is difficult to transfer to the nail bed; Additives such as additives, difficult to control adhesion to nails and / or skin; also has the disadvantage of skin irritation
In addition, since these additives are liquid or oily, there are disadvantages such as the additives ooze from the adhesive and the adhesive properties are easy to change when the storage temperature of the patch changes sharply and the storage time is long.
In addition, depending on the amount added, the phenomenon of "pasty residue" sometimes occurs when the preparation is peeled off

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] A patch was prepared according to the following composition and production method.

[0080] 1. Terbinafine *1 20.0%

[0081] 2. Acrylic adhesive *2 79.7% (solid content)

[0082] 3. Polyisocyanate *3 0.3%

[0083] *1 : Purchased from KANEDA Co., Ltd.

[0084] *2 : Obtained by conventional solution polymerization of 96% 2-ethylhexyl acrylate and 4% acrylic acid at a concentration of 33% in ethyl acetate using 0.5 parts of polymerization initiator lauroyl peroxide. Hereinafter, the numerical value of the adhesive represents the solid content.

[0085] *3 : Coronate HL (Japan Polyurethane Industry Co., Ltd.)

[0086] (Manufacturing method) After weighing the above-mentioned components, the overall solid content was adjusted to 25% in ethyl acetate, and stirred until uniform. Coating was carried out on a 75 μm single-sided silicone-treated PET (polyethylene terephthalate) film (Filmbyna 75E-0010 No.23, Fujimori Industry Co., Ltd.) so that the thickness of...

Embodiment 7

[0094] Terbinafine was 10.0%, a silicone-based adhesive was used as a base, and a patch was prepared using the following composition table and production method.

[0095] 1. Terbinafine *1 10.0%

[0096] 2. Silicone adhesive *4 90.0%

[0097] *1 : Same as

[0098] *4 : BIO-PSA4501 (Dow Corning)

[0099] Combine polydimethylsiloxane with MQ resin (by M unit ((CH 3 ) 3 SiO 1 / 2 ) and Q units (SiO 2 ) Formed branched polysiloxane) with a composition ratio of 60:40 (mass ratio), obtained by polymerization at a concentration of 63% in heptane by a conventional solution polymerization method. Hereinafter, the numerical value of the adhesive represents the solid content.

[0100] (Manufacturing method) After weighing the above ingredients, stir until uniform. Coating was carried out on a 75 μm single-sided silicone-treated PET (polyethylene terephthalate) film (Filmbyna 161-8066FN-75, Fujimori Kogyo Co., Ltd.) so that the thickness of the adhesive layer at the time ...

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Abstract

A nail and / or skin patch for preventing or treating mycoses is provided that is able to maintain a drug concentration in the nails and / or skin horny layer at a high concentration for a long period of time without adding a dissolving agent that prevents precipitation of drug crystals or permeation enhancer that promotes penetration of drug into the nails and / or skin, retains superior adhesion even when adhered for a long period of time and has causes little skin irritation. A nail and / or skin patch for preventing or treating mycoses, which contains an antimycotic, having an octanol / water partition coefficient in the form of a logKo / w value of 4 or more, in a dissolved state in an acrylic-based pressure-sensitive adhesive layer or silicone-based pressure-sensitive adhesive layer.

Description

technical field [0001] The present invention relates to a percutaneous absorption type patch for preventing and / or treating fungal infections in nails and / or skin (hereinafter referred to as mycoses). More specifically, it relates to a percutaneous absorption type patch having good drug penetration into nails and cuticles and high therapeutic effects. Background technique [0002] Among the fungal diseases infected by the majority of Japanese, tinea pedis, skin candidiasis, and purpura can be listed as representatives, but tinea tinea is the most common among them, and 1 in 4 Japanese people is infected with tinea tinea. And it is said that 1 out of 8 people will suffer from onychomycosis, which is difficult to cure, and 1 out of 2 people over the age of 60 will suffer from white tinea. [0003] In recent years, due to the remarkable progress of antifungal drugs, the treatment results of tinea pedis, which is the most important disease among fungal diseases, have been signi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/137A61K47/32A61P31/10
CPCA61K9/7061A61K9/7069A61K31/137A61P17/00A61P31/10
Inventor 川原康慈岛田纪子
Owner NICHIBAN KK
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