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Safe blood or blood component storage container and preparation method thereof

A blood component and storage container technology, applied in the field of medical devices, can solve the problems of easy damage, leakage, high production cost of storage containers, high material cost, etc., and achieve reduced adsorption and coagulation, excellent blood compatibility, and mechanical properties excellent effect

Active Publication Date: 2009-09-23
SHANDONG WEIGAO GROUP MEDICAL POLYMER +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] (1) The heat resistance of the material is poor, and the prepared blood and blood component storage bags will be deformed after high-temperature steam sterilization
[0007] (2) The mechanical properties of the material are poor
The prepared non-polyvinyl chloride blood and blood component storage bags are not high in strength, and are prone to damage and leakage during application
[0008] (3) The anti-hemolysis performance of the material is poor. The small molecule ester compounds added to improve the anti-hemolysis performance, such as: butyryl tri-n-hexyl citrate and citric acid ester, will penetrate into the blood or liquid medicine and cause harm to the human body. potential hazard
[0009] (4) The cost of materials is much higher than that of polyvinyl chloride materials, resulting in high production costs for storage containers
[0010] (5) The dielectric constant of the material is generally small, and the simple and low-cost high-frequency welding cannot be used. The blood bag production process is more difficult and the cost is higher.
The above-mentioned non-polyvinyl chloride materials use polyolefin as the main substrate, and their bonding performance is not good, which is not conducive to the connection between bags and the assembly of accessories
[0011] The use of non-polyvinyl chloride blood bag materials to prepare single-layer plastic films cannot meet the requirements of blood component storage containers

Method used

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  • Safe blood or blood component storage container and preparation method thereof
  • Safe blood or blood component storage container and preparation method thereof
  • Safe blood or blood component storage container and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Weigh A1 and B1 materials and add them to the double-layer co-extrusion blow molding unit respectively. The screw diameter of the extruder unit is 40mm, the length-to-diameter ratio is 36, and the head is the center feed of the inner layer and the side feed of the outer layer for co-extrusion. Blow-molded structure. Set the temperature of the feed section of the extruder for material A1 to 150-160°C, the temperature of the compression section to 160-170°C, and the temperature of the metering section to 170-185°C; set the temperature of the feed section of the extruder for material B1 to 140-155°C, The temperature of the compression section is 150-165°C, the temperature of the metering section is 160-175°C; the temperature of the double-layer co-extrusion blow molding head is set at 170-180°C. After drying the polyurethane and polyvinyl chloride with a weight ratio of 1:4, add them to the hopper of the polyurethane extruder and the hopper of the polyvinyl chloride extrud...

Embodiment 2

[0041] Weigh A1 and B2 materials and add them to the double-layer co-extrusion blow molding unit respectively. The screw diameter of the extrusion unit is 40mm, and the length-to-diameter ratio is 36. plastic structure. Set the temperature of the feed section of the extruder for material A1 to 150-160°C, the temperature of the compression section to 160-170°C, and the temperature of the metering section to 170-185°C; set the temperature of the feed section of the extruder for material B2 to 140-155°C, The temperature of the compression section is 150-165°C, the temperature of the metering section is 160-175°C; the temperature of the double-layer co-extrusion blow molding head is set at 170-180°C. After drying the polyurethane and polyvinyl chloride with a weight ratio of 1:7, add them to the hopper of the polyurethane extruder and the hopper of the polyvinyl chloride extruder of the double-layer co-extrusion blow molding unit, start the machine, and set the polyurethane extrud...

Embodiment 3

[0045] Weigh the A2 and B1 materials and add them to the double-layer co-extrusion blow molding unit respectively. The screw diameter of the extruder unit is 40mm, the length-to-diameter ratio is 36, and the head is the center feed of the inner layer and the side feed of the outer layer for co-extrusion. Blow-molded structure. Set the temperature of the feed section of the extruder for material A2 to 150-160°C, the temperature of the compression section to 160-170°C, and the temperature of the metering section to 170-185°C; set the temperature of the feed section of the extruder for material B1 to 140-155°C, The temperature of the compression section is 150-165°C, the temperature of the metering section is 160-175°C; the temperature of the double-layer co-extrusion blow molding head is set at 170-180°C. After drying the polyurethane and polyvinyl chloride with a weight ratio of 1:7, add them to the hopper of the polyurethane extruder and the hopper of the polyvinyl chloride ex...

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Abstract

The invention provides a safe blood or blood component storage container and a preparation method thereof. The storage container comprises a storage bag and a tube; wherein, the storage bag is made of a polyurethane / polyvinyl chloride double-layer composite cylinder film; the tube is made of a polyurethane / polyvinyl chloride double-layer composite tube; the inner layer of the polyurethane / polyvinyl chloride double-layer composite cylinder film is made of polyurethane, and the corresponding outer layer thereof is polyvinyl chloride; the inner surface of the polyurethane / polyvinyl chloride double-layer composite tube is a polyurethane layer, and the outer surface thereof is a polyvinyl chloride layer. The polyurethane / polyvinyl chloride double-layer composite cylinder film is prepared by a co-extrusion blow molding method, and the polyurethane / polyvinyl chloride double-layer composite tube is prepared by a co-extrusion method. The storage container has excellent blood compatibility, can avoid micromolecules such as phthalate di (2- ethylhexyl), plasticizer and the like to pollute the blood, meets the requirements of humid hot sterilization on heat resistance, has the advantages of high mechanical strength, easy bonding and low manufacturing cost, and is suitable for high frequency soldering.

Description

technical field [0001] The invention relates to a medical device, in particular to a safe blood or blood component storage container and a preparation method thereof. Background technique [0002] Polyvinyl chloride is cheap and has excellent comprehensive properties, and is widely used as a material for disposable infusion sets and blood transfusion sets. With the extensive and in-depth clinical application and the development of related medical science and technology, it has been found that the polyvinyl chloride material itself has potential safety hazards, and there are also many defects in processing and use performance. A small amount of vinyl chloride monomer will be produced in the production or processing of polyvinyl chloride resin, which has been proved to be a carcinogen. In order to obtain soft polyvinyl chloride products, plasticizers must be used in processing, among which, bis(2-ethylhexyl phthalate) (DEHP) plasticizers are used the most, and such plasticize...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J1/05
Inventor 栾世方殷敬华石恒冲
Owner SHANDONG WEIGAO GROUP MEDICAL POLYMER
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