Polyester type biodegradable shape memory polymeric compounds and methods of formulating same

Abstract

The invention relates to a polyester type biodegradable shape memory polymer and a preparation method thereof. The product is essentially formed by the copolymerization and the cross linking of sebacic acid, propanetriol and diol. The method is as follows: a. the sebacic acid and the diol are copolymerized, and the propanetriol is added for copolymerizing; and b. the product is obtained by moulding, cross linking and solidifying. The product has the advantages of large deformation, the high restoration ratio of deformation and good biocompatibility. The shape restoration temperature is 0 DEG C to 45 DEG C; the tensile strength is 0.5-10MPa; and the degradation time is 30 to 300 days. The polyester type biodegradable shape memory polymer can be used as material for repairing human body soft tissue injury, such as cornea, retina, skin, blood vessel, connective tissue, islet tissue, musculature, nervous tissue, etc. The method has simple technology and convenient operation.

Description

technical field [0001] The invention relates to a biodegradable shape memory polymer and a preparation method thereof. Background technique [0002] At present, the biodegradable shape memory polymers that have been developed include: Langer's research group uses poly-1,4-dioxane-2-ketone oligomer as the stationary phase, polycaprolactone oligomer or polylactide glycol Lactide copolymers are reversibly synthesized multi-block copolymers and polycaprolactone oligomers are reversibly synthesized methacrylate crosslinked polymers (US Patent 6160084); Memory properties, biodegradable and bioabsorbable polylactic acid (US Patent 6281262) and the like. However, the mechanical properties of these materials are only suitable for the performance requirements of the hard tissues (such as bone) of the human body, which are very different from the mechanical properties of the soft tissues of the human body, and are greatly restricted in use; The degradation mechanism of degradable sha...

AI Technical Summary

Problems solved by technology

However, the mechanical properties of these materials are only suitable for the performance requirements of the hard tissues (such as bone) of the human body, which are very different from the mechanical properties of the soft tissues of the human body, and are greatly restricted in use; The degradation mechanism of degradable shape memory polymers belongs to bulk degradation. After implantation in the body, before the quality and shape have changed, the mechanical properties have rapidly decayed, and the overall collapse occurs, which makes the initial implantation purpose unable to be met.

In addition, the shape recovery temperature of these materials is far from the body temperature of the human body, so they cannot be directly used in the living body.