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Chitosan uterus-neck antibiotic film and preparation method thereof

An antibacterial film, chitosan technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, pharmaceutical sciences, etc., can solve the problems of easy prolapse of drugs, affecting efficacy, cross-infection, etc., and achieve broad-spectrum effective bactericidal repair function , good adhesion and color sensitivity, the effect of maintaining biocompatibility

Inactive Publication Date: 2009-08-19
杨玉民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tablets, suppositories, and capsules are difficult to reach and stay in the lesion, which greatly affects the curative effect of the medicine, which is also one of the main reasons why the above-mentioned gynecological diseases are prone to recurrence
[0003] In addition, ordinary tablets, suppositories, and capsules are difficult to be held by instruments, so most patients use their hands to send the drugs into the vagina, and fingers can easily bring bacteria and mold into the vagina, and they can also be taken out with the fingers , so it is easy to cause cross-infection, and the fingers cannot accurately deliver the drug to the lesion. varying degrees of pain and injury

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0026] Embodiment: a kind of chitosan cervical antibacterial membrane adopts following weight component formula:

[0027] Gelatin 5%

[0028] Water Soluble Chitosan 5%

[0029] Tween 800.6%

[0030] Glycerin 0.5%

[0031] Shell iodine 1%

[0032] The rest is water.

[0033] Among them, shell iodine is as described in Chinese patent 200610081452.2.

[0034] The following process steps are used:

[0035] Step 1: Under sterile conditions, adjust the pH value of the distilled aqueous solution to 2.0-3.0 with phosphoric acid;

[0036] Step 2: Put the prepared solution into a vacuum stirring container, set the water melting temperature at 50-60°C, then put 5% gelatin in and start the vacuum device to stir for 1-4 hours, so that the gelatin is completely dissolved in the solution;

[0037] Step 3: Add 5% water-soluble chitosan, stir for 2-6 hours, and gradually lower the temperature to 30-35°C, and stir until the water-soluble chitosan is completely dissolved and becomes a gel...

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PUM

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Abstract

The invention discloses a chitosan cervical antibacterial film and a preparation method thereof. The preparation method comprises the steps of adopting a formula of gelatin, water soluble chitosan, shell iodine, Tween 80 and glycerol compositions and controlling the pH value, the temperature and the stirring time under the stirring of a vacuum stirrer to prepare a blending polymeric material. The chitosan cervical antibacterial film can maintain the biocompatibility and degradability of original materials, can also ensure that the polymeric material has good bactericidal performance, is used for preventing and treating common gynaecological diseases (cervicitis, after the physiotherapy and surgical treatment of uterine necks), and is a therapeutic biopolymeric material with excellent dual functions of sterilization and repair.

Description

technical field [0001] The invention relates to a chitosan cervical antibacterial membrane and a preparation method thereof. Background technique [0002] Cervicitis, vaginitis, and cervical ulcer are common diseases in women, and their incidence rate is relatively high. Patients with itching, leucorrhea, and odor are prone to infection, recurrence, and erosion and bleeding, which bring great harm to the patient. Pain, especially for patients with chronic cervicitis, if not treated in time, it is easy to cause cervical cancer. There are two kinds of treatment methods commonly used at present for cervicitis and vaginitis, and a kind of is to lavage with water, and another kind is to insert tablet medicine, suppository medicine, capsule medicine etc. into vaginal lesion position. However, tablets, suppositories, and capsules are difficult to reach and stay in the lesion, thereby greatly affecting the curative effect of the medicine, which is also one of the main reasons for t...

Claims

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Application Information

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IPC IPC(8): A61K31/722A61K47/42A61K9/70A61P15/00A61L15/32A61L15/44A61K33/18
Inventor 杨玉民
Owner 杨玉民
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