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Biological degradable metal stent coated with rapamycin-probucol composite medicament

A metal stent, drug coating technology, applied in stents, coatings, medical science and other directions, can solve the problem of stents prone to local inflammation, and achieve good biodegradability, good corrosion resistance, high fatigue resistance and fracture resistance. The effect of capacity and tensile strength

Active Publication Date: 2009-07-22
LEPU MEDICAL TECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, further research on drug-eluting stents is needed to solve the problems of stents prone to local inflammation and late stent thrombosis

Method used

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  • Biological degradable metal stent coated with rapamycin-probucol composite medicament
  • Biological degradable metal stent coated with rapamycin-probucol composite medicament
  • Biological degradable metal stent coated with rapamycin-probucol composite medicament

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The base part of the metal stent described in this embodiment is laser-engraved with L605 cobalt-chromium alloy as an open-loop design shape.

[0026] First take the mixture of rapamycin, probucol and polyglycolide (PGA) respectively according to the weight ratio of 1:1:3 and dissolve them in trichloroethane, the total weight concentration is 1.5%, mix at room temperature Disperse evenly, and then ultrasonically spray on the surface of the metal stent. Cured in air for 30min. Repeat the above operation process until the drug loading of the stent reaches the requirement (rapamycin 1.6ug / cm 2 , Probucol 2.0ug / cm 2 , coating thickness 5mm). Finally, the scaffold was dried in a vacuum oven for 0.5 h. figure 1 Scanning electron micrograph of the completed drug-coated stent, figure 2 A cross-sectional view of the coated stent.

[0027] Among them, polyglycolide (PGA) can be replaced by polylactide (PLA) or polycaprolactone (PCL), or a copolymer of two or three of the t...

Embodiment 2

[0030] The base part of the metal bracket described in this embodiment is laser-engraved with 316L stainless steel to form a hollow diamond structure.

[0031] First take the mixture of rapamycin, probucol and polylactide (PLA) in the weight ratio of 20:5:60 and dissolve them in methanol, the total weight concentration is 2.0%, mix and disperse evenly at 40°C, and then Ultrasonic spraying on the surface of the metal stent. Cured in air for 50min. Repeat the above operation process until the drug loading of the stent reaches the requirement (rapamycin 1.2ug / cm 2 , Probucol 2.0ug / cm 2 , coating thickness 3mm). The scaffolds were then dried in a vacuum oven for 16 hours.

Embodiment 3

[0033] The base part of the metal stent described in this embodiment is laser-engraved with a nickel-titanium alloy into a "Z" corrugated shape.

[0034]First take the mixture of rapamycin, probucol and polycaprolactone (PCL) in a weight ratio of 40:30:50 and dissolve them in tetrahydrofuran, the total weight concentration is 3.0%, and mix and disperse evenly at 60°C. Then it is ultrasonically sprayed on the surface of the metal stent. Cured in air for 30min. Repeat the above operation process until the drug loading of the stent reaches the requirement (rapamycin 2.0ug / cm 2 , Probucol 1.0ug / cm 2 , coating thickness 1mm). The scaffolds were then dried in a vacuum oven for 32 hours.

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Abstract

The invention provides a biodegradable rapamycin-probucol composite medicine coated metal stent, which comprises a metal stent, active ingredients which coat on the surface of the metal stent, and a slow release vector, wherein the active ingredients are rapamycin and probucol; and the slow release vector is in vivo degradable fatty cluster polymers. The coated metal stent not only maintains the advantage of preventing restenosis of the medicine coated stent but also solves the problem of late stent thrombus along with complete release of a slow release coating; and the probucol in the coating has the function of inhibiting local inflammatory reaction caused by the vector and a medicine. The coated metal stent is mainly used for interventional therapy of coronary heart disease, prevention of restenosis, and reduction of formation of late thrombus after the stent is implanted.

Description

technical field [0001] The invention relates to a metal stent provided with a sustained-release drug coating. The sustained-release drug coating refers to a composite drug coating containing rapamycin and probucol, and the coating has a sustained-release effect. It is mainly used for interventional treatment of coronary heart disease, prevention of restenosis, and reduction of late thrombus formation after stent placement. Background technique [0002] With changes in lifestyle, the incidence of atherosclerosis continues to increase. Coronary atherosclerosis has become the primary factor threatening human life. The development of interventional therapy for coronary heart disease has brought good news to such patients. Scientific progress has promoted the development of coronary interventional therapy, but the problem of postoperative restenosis still plagues clinical treatment. Whether it is simple balloon expansion or bare metal stent placement, the endothelial tear caus...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/54A61F2/82A61L27/04
Inventor 张正才王玲赵丽晓昌仁操张昱昕蒲忠杰
Owner LEPU MEDICAL TECH (BEIJING) CO LTD
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