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Pharmaceutical composition for enhancing immunity of fowl and coordinating with vaccine for synergy

A technology of composition and immunity, applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of unsatisfactory application effect, decreased immunity, and inability to establish a sufficient immune environment, so as to reduce losses and make the body non-toxic Harmless, humoral immunity boosting effect

Active Publication Date: 2009-07-08
HUNAN AGRI UNIV ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In many cases, most of the existing vaccines are unsatisfactory, such as the body is in a state of immunodeficiency or sub-health, and it is often impossible to establish a sufficient immune environment in poultry or even cause immunity to decline

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4

[0033] The preparation of embodiment 1~4 pharmaceutical composition of the present invention

[0034] Including the following steps:

[0035] (1) Astragalus polysaccharide (purchased from Sichuan Tongtai Plant Chemical Co., Ltd.), glycyrrhizin (purchased from Xi’an Fujie Pharmaceutical Co., Ltd.), icariin (purchased from Shaanxi Senfu Biotechnology Co., Ltd.), propolis (purchased from Dongguang Orchard Natural Beeswax Co., Ltd., Hebei Province), vitamin E (purchased from Zhejiang Pharmaceutical Co., Ltd. Xinchang Pharmaceutical Factory) mixed with 0.5% Tween 80, and then added 5% ethanol to dissolve , to obtain the original liquid medicine;

[0036] (2) Get ethylparaben 0.5g and dissolve in distilled water to obtain antiseptic solution;

[0037] (3) Add the preservative solution in step (2) into the original drug solution in step (1) under stirring, mix and stir evenly, set the volume to 1000ml with distilled water, pack into pots and seal, and sterilize with circulating ste...

Embodiment 5

[0040] Embodiment 5 Pharmaceutical composition of the present invention enhances chicken body immunity and vaccine synergism test:

[0041] 1 Materials and methods

[0042] 1.1 Materials

[0043] 1.1.1 Test animals

[0044] 500 non-immune healthy broiler chickens were purchased from a chicken farm in Langfang and kept in isolation until the required age.

[0045] 1.1.2 Vaccines

[0046] Avian influenza and Newcastle disease recombinant dual live vaccine (rL-H5 strain) were purchased from Harbin Veken Biotechnology Development Company; Bursal of Fabricius vaccine B87 was purchased from Huadu Biotechnology Co., Ltd.

[0047] 1.1.3 Main reagents

[0048] Avian influenza H5 subtype HI antigen and Newcastle disease antigen were purchased from Harbin Veken Biotechnology Development Company; Bursal of Fabricius antigen was purchased from Qianyuanhao Biotechnology Co., Ltd.

[0049] 1.2 Method

[0050] 1.2.1 Grouping and treatment of experimental chickens: 500 non-immune healthy...

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PUM

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Abstract

The invention discloses a pharmaceutical composition with the functions of enhancing the fowl immunity and matching vaccine to enhance the efficacy. The components and the weight percentage thereof are as follows: 0.5 to 5 percent of astragalus polyose, 0.5 to 5 percent of glycyrrhizin, 0.5 to 5 percent of icariine, 0.5 to 3 percent of propolis, 0.02 to 0.1 percent of vitamin E and addition agents. The pharmaceutical composition of the invention can obviously improve both the fowl body cellular immunity and the humoral immunity, and has favorable functions of preventing and controlling the immunosuppressive diseases of the fowl; second, the pharmaceutical composition can be matched with the vaccine to be used to improve the fowl antibody titer, thereby causing the antibodies to be comparatively uniform and to maintain a higher level and showing obvious functions of immunization and efficacy enhancement; and the pharmaceutical composition can be matched with medicines for curing the fowl newcastle disease, the bursa of fabricius, the bird flu and the like, thereby improving treatment effects, increasing the antibody guard time and reducing loss.

Description

technical field [0001] The invention relates to a pharmaceutical composition capable of enhancing poultry immunity and synergizing vaccines. Background technique [0002] In the prevention and control measures of the poultry industry around the world, the use of vaccines for specific prevention of various viral and bacterial diseases plays an important role. In many cases, most of the existing vaccines have unsatisfactory application effects, such as the body is in a state of immunodeficiency or sub-health, and it is often impossible to establish a sufficient immune environment in poultry or even cause immunity to decline. In addition, immunosuppression will directly interfere with the immune response of chickens to vaccines. There are many reasons for immunosuppression, including infectious factors, such as Newcastle disease, infectious bursitis, coccidiosis, etc.; there are also many non-infectious factors , Such as various toxins, malnutrition, stress, etc., in addition ...

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K39/39A61P37/04A61K31/355A61K35/64A61K35/644
Inventor 伍冶金中辉高山松
Owner HUNAN AGRI UNIV ANIMAL PHARMA
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