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Micropore ceramics and method for sustained-release of medicament or biological preparation and use thereof

A technology of microporous ceramics and biological preparations, applied in the field of microporous ceramics, can solve the problems of high price, large drug damage, affecting the activity of biological preparations, etc., and achieve the effect of reducing side effects

Inactive Publication Date: 2009-06-24
卢建熙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the curative effect of sustained-release drugs has been affirmed. However, the production of sustained-release drugs is complicated, the price is expensive, the drug loss is large, and the drug capacity in the sustained-release preparations is limited, and other unfavorable factors will affect the activity of biological agents, which cannot be achieved. Tissue and organ repair and reconstruction

Method used

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  • Micropore ceramics and method for sustained-release of medicament or biological preparation and use thereof
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  • Micropore ceramics and method for sustained-release of medicament or biological preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Adopt the tricalcium phosphate of powder grain 1-2 micron as ceramic raw material, make the cylindrical microporous ceramic box of diameter 30 millimeters and height 20 millimeters, wall and lid thickness are 5 millimeters ( image 3 ). The micropore diameter is 1-2 microns, and the microporosity is 5%.

[0033] Specific steps are as follows:

[0034] 1) Make corresponding molds according to the shape and size of the product;

[0035] 2) 65% ceramic powder + 30% pure water + 5% dispersant and binder were stirred for 3 hours to prepare a slurry;

[0036] 3) The slurry is poured into the mold, dried for 10 hours to form, demolded and trimmed to obtain a ceramic green body;

[0037] 4) Move the green body into the debinding furnace and heat up to 370°C to eliminate organic matter;

[0038] 5) Move it into a high-temperature sintering furnace, gradually heat up to 1000°C, and sinter for 3 hours to form a microporous ceramic product.

Embodiment 2

[0040] Adopt tricalcium phosphate (85%) of powder 1-2 micron and charcoal of 2-4 micron as microporous agent (15%), make the cylindrical microporous ceramic box of diameter 30 millimeters and height 20 millimeters, wall thickness 5 mm, the drug storage cavity is cylindrical with a diameter of 20 mm and a height of 10 mm, and a drug injection hole with a diameter of 0.5 to 1.5 mm communicated with the drug storage cavity on the top ( figure 2 -A). The micropore diameter is 1-3 microns, and the microporosity is 15%.

[0041] Specific steps are as follows:

[0042] 1) Make corresponding molds according to the shape and size of the product;

[0043] 2) 85% ceramic powder + 15% microporous agent was stirred for 3 hours to make a mixture;

[0044] 3) Pour the mixture into the mold, continue to press at 100MPa for 30 minutes, and demould to form a ceramic green body;

[0045] 4) Move the green body into the debinding furnace and heat up to 500°C to eliminate organic matter;

[...

Embodiment 3

[0048] Tricalcium phosphate with a powder size of 2-4 microns is used as a ceramic raw material, and PMMA spherical particles with a size of 300-500 microns are used as a pore-forming agent. Make a cylindrical microporous ceramic box with a diameter of 30 mm and a height of 20 mm. The wall thickness is 5 mm. Injection hole ( figure 2 -B). The microporous ceramic part has a pore size of 1-3 microns and a porosity of 15%. The porous ceramic part has a pore size of 350-450 microns and a porosity of 65%.

[0049] Specific steps are as follows:

[0050] 1) Make corresponding molds according to the shape and size of the product;

[0051] 2) Place PMMA spherical particles in the mold cavity, add acetone for 10 minutes, and rinse with pure water to obtain a cylindrical porous framework;

[0052] 3) 65% ceramic powder + 30% pure water + 5% dispersant and binder, mixed for 3 hours to prepare a slurry;

[0053] 4) placing the porous framework in the cavity of the mold and pouring ...

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Abstract

The invention relates to microporous ceramics capable of slowly releasing medicines and biological agents, a method for preparing the same and application thereof. By utilizing the slow release effect of the microporous biological ceramics and accurately controlling the size and density of micropores, microporous biological ceramic products with different forms, structures and sizes are prepared; and the medicines and the biological agents are loaded in the microporous biological ceramic products. In the method, a ceramic blank is added with a soluble or volatile fine grain, or the size of ceramic power grains is controlled, or the sintering temperature is controlled, so that the size and density of the micropores, which are required in design, are formed in the biological ceramics. By the mold pressing method and the grouting method, products with different forms, structures and sizes can be prepared; furthermore, the single microporous ceramics, microporous / porous composite ceramics, microporous / compact substance composite ceramics, or microporous / porous / compact substance composite ceramics can be prepared; and the effects of medicine storage and slow release are achieved by the micropore, and the double biological reconstruction of bone defect and slow release of the medicine is completed.

Description

technical field [0001] The present invention relates to a microporous ceramic for sustained release of drugs and biological agents, method and use thereof. The main functions of the microporous ceramics are: 1) using the cavity of the ceramic to display the drug storage function; 2) using the micropores of the ceramic to express the sustained release effect; 3) utilizing the configuration and strength of the ceramic to achieve the function of repairing and rebuilding. It belongs to the field of bioceramics. technical background [0002] Among the organic diseases of the human body, a considerable part is local lesions. The traditional treatment method is through oral, arteriovenous and anorectal administration, but most of the drugs are consumed by human organs, and the corresponding concentration cannot be reached at the treatment site. In this way, super-large doses of drugs are forced to be administered, and the therapeutic effect can be achieved, but the toxicity and s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/00C04B38/06A61L27/10A61L27/56A61L27/54
Inventor 卢建熙王臻金芳纯肖建如谢幼专
Owner 卢建熙
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