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Application of hydroxybetulinic acid compound in preparation of dermatosis drugs

A technology of betulinic acid and compounds, applied in the field of skin medicine, can solve the problems of increasing the cost and toxicity of drug administration, and high doses of Chinese medicine extracts

Pending Publication Date: 2022-07-08
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional Chinese herbal medicines are used clinically for systemic treatment of skin diseases, however, when using Chinese herbal medicines for systemic treatment, higher doses of Chinese herbal extracts are required compared to topical treatments, thus increasing administration costs and toxicity
There are few studies on the efficacy of topical application of Chinese herbal medicines in allergic skin diseases such as eczema and contact dermatitis

Method used

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  • Application of hydroxybetulinic acid compound in preparation of dermatosis drugs
  • Application of hydroxybetulinic acid compound in preparation of dermatosis drugs
  • Application of hydroxybetulinic acid compound in preparation of dermatosis drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Therapeutic effect of ointment on dermatitis

[0030] Weigh stearic acid, glycerol monostearate, liquid paraffin, and white petrolatum, heat and melt in a water bath at 70 °C as an oil phase, weigh the hydroxy betulinic acid compound powder, glycerin and distilled water, and heat and melt in a water bath at 70 °C. as the aqueous phase. Then, under stirring, the water phase is poured into the oil phase to form an ointment to obtain a hydroxy betulinic acid compound W / O type ointment transdermal preparation. The final concentration of each component is 1% hydroxy betulinic acid compound, 5% stearic acid, 10% glycerol monostearate, 10% liquid paraffin, 10% white petrolatum, and 9% glycerin.

[0031] Thirty-five Balb / c mice were randomly divided into normal control group, model group, dexamethasone positive drug group (7.5mg / kg), hydroxybetulinic acid compound ointment low-dose group (6.6mg / kg), Acid compound ointment high-dose group (13.2 mg / kg), 7 animals in e...

Embodiment 2

[0034] Example 2 Therapeutic effect of skin gel on anaphylactic shock

[0035] Weigh Carbomer 940, sprinkle it in distilled water, and let it stand overnight; dissolve glycerin and propylene glycol in distilled water, pour it into fully swollen Carbomer 940, and use it as a gel matrix for later use. Mix the hydroxybetulinic acid compound powder with distilled water, dissolve the drug solution in the gel matrix under the condition of 40 ℃, stir, then add 10% sodium hydroxide solution to adjust the pH value to 6.2, add distilled water to quantify to 100 g , to obtain a hydroxy betulinic acid compound gel; the final concentration of each component is 1% of hydroxy betulinic acid compound, 1% of carbomer 940, 1% of glycerin, and 1.1% of propylene glycol.

[0036] To study the improvement effect of the above-mentioned gel on the mouse death model induced by excessive DNCB (2,4-dinitrochlorobenzene), the following experiments were designed. Thirty-five Balb / c mice were randomly div...

Embodiment 3

[0037] Example 3 Therapeutic effect of solution spray on eczema

[0038] Weigh the hydroxy betulinic acid compound powder, add distilled water to dissolve, then add glycerin, sodium benzoate, rose essence and mix well, and add water to 1000 mL to obtain the hydroxy betulinic acid compound solution. The final concentration of each component is 0.7% hydroxybetulinic acid compound, 7% glycerin, 0.25% sodium benzoate, and 0.5% rose essential oil. Can be applied to the skin as a smear or spray.

[0039]To study the improvement effect of the drug on DNCB (2,4-dinitrochlorobenzene)-induced mouse eczema model, the following experiments were designed. 35 Balb / c mice were randomly divided into normal control group, model group, dexamethasone positive drug group (7.5 mg / kg), low-dose solution spray group (6.6 mg / kg), and solution spray high-dose group according to body weight. Dosage group (13.2 mg / kg), 7 in each group. One day before the experiment, the skin of the back of the mice w...

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Abstract

The invention belongs to a skin medication technology, and particularly relates to application of a hydroxybetulinic acid compound in treatment of skin diseases, especially eczema, inflammatory skin diseases and allergic shock. According to the invention, various skin external administration dosage forms, including a solution, a gel, an ointment, a patch, an emulsion and a film spraying agent, are designed, are used for local administration of various skin diseases, have the advantages of remarkable drug effect and small toxic and side effects, and particularly solve the problems of digestive tract toxicity and large dosage of the existing oral drug. Researches show that the method for treating the skin diseases is effective, safe and low in treatment cost, and in a mouse model, development of eczema and dermatitis can be restrained, and allergic shock can be relieved.

Description

technical field [0001] The invention belongs to the technology of skin medicine, in particular to the application of a hydroxybetulinic acid compound in the treatment of skin diseases, especially eczema, inflammatory skin diseases and anaphylactic shock. Background technique [0002] Dermatitis is a common skin disease in humans, and irritant contact dermatitis is a non-immune reaction that occurs from direct damage to the skin by chemical substances or physical agents, which is faster than the skin can repair itself. About 80% of contact dermatitis cases are irritant contact dermatitis. Common irritants include soaps, detergents, water, solvents, and certain food ingredients. Currently, the most common treatments for these diseases include systemic or topical corticosteroids or immunomodulators. Although these drugs usually improve clinical symptoms, systemic or local side effects may occur with long-term use. For example, administration of cyclosporine A increases regul...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P17/00A61P37/08A61P9/02A61P29/00
CPCA61K31/704A61K9/0014A61P17/00A61P37/08A61P9/02A61P29/00
Inventor 刘艳丽许琼明丁大伟李恒苏疏影
Owner SUZHOU UNIV
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