Ethyl acetate extract of Chinese caterpillar fungus, preparation method and use thereof in antiviral medicine

A technology of ethyl acetate extraction and ethyl acetate, which is applied to antiviral agents, pharmaceutical formulations, plant raw materials, etc., can solve the problems of incomplete extraction of active ingredients and few reports on research on antiviral effects, and achieve no plasma coagulation activity. , good antiviral ability, improve the effect of drug efficacy

Inactive Publication Date: 2009-06-10
孟繁宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical feature of the extraction and preparation technology of the active components of the original Cordyceps militaris is that the Cordyceps militaris mycelium is boiled and alcohol-precipitated to extract various active components of proteins and polysaccharides in the Cordyceps militaris, and the active components are often incompletely extracted.
In addition, the pharmacological effects of active ingredients in Cordyceps militaris are limited to improving the body's immunity, and there are few reports on its antiviral effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of ethyl acetate extract of Cordyceps militaris:

[0032] (1) Grind the dried Cordyceps militaris mycelium to obtain 20 g of mycelium powder, add 200 ml of ethyl acetate, extract with a Soxhlet extractor at 77° C. for 8 hours under reflux, and filter to obtain filtrate 1.

[0033] (2) Extract 25.8 g of the filter residue with 258 ml of deionized water at 100°C for 3 hours, and filter to obtain filtrate 2.

[0034] (3) Filtrate 1 and filtrate 2 were combined, and concentrated under reduced pressure to constant weight to obtain the ethyl acetate extract of Cordyceps militaris.

Embodiment 2

[0036] Preparation of ethyl acetate extract of Cordyceps militaris:

[0037] (1) Grind the dried Cordyceps mycelium, take 35 g of mycelium powder, add 350 ml of ethyl acetate, extract with a Soxhlet extractor at 93° C. for 11 h under reflux, and filter to obtain filtrate 1.

[0038] (2) Extract 40.5 g of filter residue with 405 ml of deionized water at 100° C. for 3 h, and filter to obtain filtrate 2 .

[0039] (3) Filtrate 1 and filtrate 2 were combined, and concentrated under reduced pressure to constant weight to obtain the ethyl acetate extract of Cordyceps militaris.

Embodiment 3

[0041] Preparation of ethyl acetate extract of Cordyceps militaris:

[0042] (1) Crush the dried Cordyceps militaris mycelium to obtain 43 g of mycelium powder, add 430 ml of ethyl acetate, extract with a Soxhlet extractor at 86° C. for 9 hours, and filter to obtain filtrate 1.

[0043] (2) Extract 48.7 g of filter residue with 487 ml of deionized water at 100° C. for 4.5 h, and filter to obtain filtrate 2.

[0044] (3) Filtrate 1 and filtrate 2 were combined, and concentrated under reduced pressure to constant weight to obtain the ethyl acetate extract of Cordyceps militaris.

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PUM

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Abstract

The invention provides a cordycep militaris ethyl acetate extract and preparing process thereof, further discloses a purpose of the extract for preparing antiviral remedies. The preparing process comprises: smashing the dry cordyceps militaris, adding ethyl acetate, extracting and filtering in back flow manner by a Soxhlet extractor, and getting a filtrate; eluting the residue by ion liquid, filtering and get another filtrate; combining the tow filtrates, decompressing and concentrating to a constant weight to obtain the final extract. Extracting the effective constituents of the cordycep militaris by using ethyl acetate can increase the extraction rates of multiple effective constituents to higher limit, thereby improve medicine effect. The cordycep militaris ethyl acetate extract is a product obtained from natural resources, achieves excellent antivirus capacity, and advantages of no hemolytic activity and no plasma clkotting activity verified by experiment, can be used for preparing medicine for preventing AIDS, hepatitis B and virus form flu. The invention provides a new selection to the medicine for preventing AIDS, hepatitis B and virus form flu utilizing the abundant natural resources in our country.

Description

Technical field: [0001] The invention relates to an ethyl acetate extract of Cordyceps militaris, a preparation method and its application in antiviral drugs, which belong to the technical field of extraction and application of effective components of traditional Chinese medicine, and also belong to the field of biochemical pharmacy. Background technique: [0002] Cordyceps militaris (Cordyceps militaris), also known as Cordyceps militaris and Cordyceps militaris, belongs to Ascomycotina, Clavicipitaceae, and Cordyceps. Under the condition that the supply of Cordyceps sinensis is in short supply, Cordyceps militaris, which is as famous as Cordyceps sinensis, has attracted more and more attention in the world. Its development and production have developed new sources of nutrition and medicine for the fields of human health care and medicine. "Compendium of Xinhua Materia Medica" records that Cordyceps militaris is "flat in nature, sweet in taste, beneficial to the lungs and k...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/068A61P31/12
Inventor 孟繁宇
Owner 孟繁宇
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