Cefmenoxime hydrochloride preparation for injection and preparation method thereof

A technology of cefmenoxime hydrochloride and cefmenoxime, which is applied in the field of pharmaceutical preparations, can solve the problems of large usage, hemolytic anemia, agranulocytosis and the like, and achieve the effects of improving safety and reducing adverse reactions

Inactive Publication Date: 2009-06-03
HAINAN LINGKANG PHARMA CO LTD
View PDF0 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, cefmenoxime in China is a powder preparation for injection, and the amount of use is relatively large. According to the instruction manual of cefmenoxime, the daily dosage of adult mild infection is 1-2g; the dosage of moderate and severe infection can reach 4g. Cause some serious adverse reactions, such as neutropenia or agranulocytosis, and even hemolytic anemia

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Preparation composition:

[0015] Cefmenoxime 100g

[0016] Soy Lecithin 600g

[0017] Cholesterol 200g

[0018] Disodium hydrogen phosphate appropriate amount

[0019] Weigh soybean lecithin and cholesterol in proportion, add an appropriate amount of absolute ethanol to dissolve, heat to evaporate the ethanol, add an appropriate amount of disodium hydrogen phosphate buffer, adjust the pH value to 6.5-7.5, and pass through a 0.8 μm microporous membrane after fully hydrating Two times to prepare blank liposomes.

[0020] Add prescription amount cefmenoxime and a certain amount of NaHCO in blank liposome 3 Solution, adjust the pH value to 6.5-7.5, mix under shaking, add appropriate amount of water for injection, keep warm in 70°C water bath for 20 minutes, then immediately cool down with cold water to obtain cefmenoxime liposome preparation.

[0021] The above-mentioned cefmenoxime liposome preparation is sterilized by a filter membrane with a...

Embodiment 2

[0023] Preparation composition:

[0024] Cefmenoxime 100g

[0025] Soy Lecithin 900g

[0026] Cholesterol 400g

[0027] Sodium bicarbonate amount

[0028] Weigh soybean lecithin and cholesterol in proportion, add an appropriate amount of absolute ethanol to dissolve, heat to evaporate the ethanol, add an appropriate amount of sodium bicarbonate buffer, adjust the pH value to 6.5-7.5, and pass through a 0.8 μm microporous membrane for two times after fully hydrating. Repeat to prepare blank liposomes.

[0029] Add prescription amount cefmenoxime and a certain amount of NaHCO in blank liposome 3 Solution, adjust the pH value to 6.5-7.5, mix under shaking, add appropriate amount of water for injection, keep warm in 70°C water bath for 20 minutes, then immediately cool down with cold water to obtain cefmenoxime liposome preparation.

[0030] The above-mentioned cefmenoxime liposome preparation is sterilized by a filter membrane with a pore size of 0.22...

Embodiment 3

[0032] Preparation composition:

[0033] Cefmenoxime 100g

[0034] Soy Lecithin 200g

[0035] Cholesterol 100g

[0036] Sodium bicarbonate amount

[0037] Weigh soybean lecithin and cholesterol in proportion, add an appropriate amount of absolute ethanol to dissolve, heat to evaporate the ethanol, add an appropriate amount of sodium bicarbonate buffer, adjust the pH value to 6.5-7.5, and pass through a 0.8 μm microporous membrane for two times after fully hydrating. Repeat to prepare blank liposomes.

[0038] Add cefmenoxime and a certain amount of NaHCO to the blank liposome 3 Solution, adjust the pH value to 6.5-7.5, mix under shaking, add appropriate amount of water for injection, keep warm in 70°C water bath for 20 minutes, then immediately cool down with cold water to obtain cefmenoxime liposome preparation.

[0039] The above-mentioned cefmenoxime liposome preparation is sterilized by a filter membrane with a pore size of 0.22 μm, then canned...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a cefmenoxime hydrochloride preparation for injection and a preparation method thereof. The main components of the cefmenoxime hydrochloride preparation are soyabean lecithin for injection, cholesterin and cefmenoxime, and the weight ratio of the soyabean lecithin, the cholesterin and the cefmenoxime is 10-2:4-1:1. The preparation method comprises the following steps: dissolving the soyabean lecithin and the cholesterin with absolute ethyl alcohol, adding buffer solution for complete hydration, and filtering with a microporous filter membrane of 0.8mum twice to obtain a blank liposome, then adding the cefmenoxime and NaHCO3 solution, adding water for injection after being evenly mixed, preserving heat in a water bath, and promptly cooling with cold water to obtain a cefmenoxime liposome preparation. The cefmenoxime hydrochloride preparation can achieve the same curative effect as the conventional cefmenoxime for injection at a low dose of the cefmenoxime and reduces adverse reaction caused by the cefmenoxime, thus causing the products to be safer and more effective.

Description

technical field [0001] The invention belongs to pharmaceutical preparations, and relates to a new preparation of cefmenoxime, in particular to a preparation of cefmenoxime hydrochloride for injection and a preparation method thereof. Background technique [0002] Cefmenoxime is the third-generation cephalosporin developed by Takeda Corporation of Japan. It was first listed in Japan in 1983, and then successively listed in the United States, South Korea and other countries. Spectrum antibiotics, its antibacterial spectrum is wider than other second-generation cephalosporins, has the same antibacterial power as other third-generation cephalosporins, and its antibacterial effect is bactericidal. [0003] The antibacterial spectrum of cefmenoxime is similar to that of cefotaxime, and it has strong antibacterial effect on Gram-negative bacteria such as Escherichia coli, Klebsiella, Proteus mirabilis, and Haemophilus influenzae; Genus, Serratia, Citrobacter, typhoid and other Sal...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/546A61K47/24A61P31/04
Inventor 陶灵萍
Owner HAINAN LINGKANG PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap