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Chinese medicine granule containing gingko extract and preparation method thereof

A technology of Ginkgo biloba extract and traditional Chinese medicine granules, which is applied in the direction of medical raw materials derived from Ginkgo biloba, drug combination, block delivery, etc., which can solve the problems of low release rate of active ingredients, lack of immediate release characteristics, easy moisture absorption, etc.

Inactive Publication Date: 2009-05-27
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the reasons of the dosage form itself, they have the following problems: ① solid oral preparations (such as tablets, capsules, etc.) have a slow disintegration rate and a low release rate of active ingredients
Such a long time is undoubtedly not helpful for the rapid release of the active ingredients of the drug
②First-pass effect problem
Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Preparation of Ginkgo biloba extract: Take 10,000g of Ginkgo biloba leaves, grind them, heat and extract 5 times the amount of acetone: water (70:30) mixture twice, each time for 2 hours, the temperature is 50-60°C, combine the extracts, and filter , concentrated under reduced pressure into ginkgo biloba extract;

[0060] Preparation of masterbatch: Take the mixture of dextrin and starch with a weight ratio of 1:1 and pass it through a 200-mesh sieve, 65% of which is used as the base material and put into the side spray pot of the fluidized bed, and the starch slurry (15%) is prepared by adding water to the starch Spray it in as a slurry, and sieve out small particles (180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time, use the remaining 35% dextrin from the powder gun Sprinkle with fine powder of starch to make the particle size of the mother core grow, and screen out the master batch wit...

Embodiment 2

[0063] Preparation of Ginkgo biloba extract: take 10000g Ginkgo biloba leaves and crush them, add 5 times the amount of 65% ethanol to reflux and extract twice, each time for 2 hours, the temperature is 60°C, combine the extracts, filter, concentrate under reduced pressure and recover ethanol to obtain Ginkgo biloba leaves Extract;

[0064] Preparation of masterbatch: Take a mixture of micropowder silica gel and chitosan with a weight ratio of 1:1 to pass through a 200-mesh sieve, 65% of which is used as the base material and put into the side spray pot of the fluidized bed, and another PVP K30 is added with water, extract, and prepared Adhesive forming agent-spray in as slurry, and sieve out small particles with a particle size of 120-180μ as the mother nucleus, then put the mother nucleus into the pot, continue to spray starch slurry, and at the same time, spray the remaining 35% from the powder gun The fine powder of micronized silica gel and chitosan is sprinkled in to mak...

Embodiment 3

[0067]Preparation of Ginkgo biloba extract: Take 1000g Ginkgo biloba, add 5 times the amount of water, decoct 2 times, each time for 2 hours, the temperature is 50-60°C, combine the extracts, concentrate, pass through the macroporous adsorption resin (AB- 8) Refining, eluting with 80% ethanol, concentrating the eluent to recover ethanol, and obtaining Ginkgo biloba extract;

[0068] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass through a 200-mesh sieve, 65% of which is put into the side spray pot of the fluidized bed as the bottom material, and starch and extract (after being folded and dried to account for the mother batch) 15% of the grain weight) and water to make a slurry and spray it in, and sieve out small particles (180-250μ) as the mother nucleus, then put the mother nucleus into the pot, continue to spray the starch slurry, and at the same time, spray it from the powder gun Sprinkle the remaining 35% dextrin and s...

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Abstract

The invention provides a traditional Chinese medicine granular preparation with ginkgo biloba extract and a preparation method thereof. Traditional Chinese medicine spheroidized particles are prepared by using the ginkgo biloba extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing ginkgo extract and a preparation method thereof. Background technique [0002] Ginkgo biloba is the leaf of Ginkgo biloba L. Contains flavonoids (more than 20 kinds), terpenoids, phenols, beneficial trace elements and 17 kinds of amino acids and other active ingredients, which can reduce serum cholesterol, increase coronary blood flow, improve cerebral blood circulation, relieve smooth muscle spasm, relax bronchi and Antibacterial and other pharmacological effects. Clinically, it is not only used in the treatment of cardiovascular and cerebrovascular diseases, but also has good effects on the nervous system and respiratory system. Scientists such as France and Germany have confirmed that Ginkgo biloba extract has significant curative effects in the treatment of cerebral ischemia, sequ...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K9/16A61P3/06A61P9/10A61P11/00A61K127/00
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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