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Chinese medicine glue rapid-release preparation for oral cavity and method for producing the same

A technology for immediate-release preparations and glues, which can be used in pharmaceutical formulations, drug delivery, medical preparations containing active ingredients, etc., and can solve problems such as disappearance and variety shrinkage.

Active Publication Date: 2012-06-20
何煜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] In the current improvement of traditional Chinese medicine, only donkey-hide gelatin has more improved preparations, and other traditional Chinese medicine glues have been improved very little. With the improvement of people's quality of life, these varieties may gradually shrink until they disappear

Method used

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  • Chinese medicine glue rapid-release preparation for oral cavity and method for producing the same
  • Chinese medicine glue rapid-release preparation for oral cavity and method for producing the same
  • Chinese medicine glue rapid-release preparation for oral cavity and method for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0146] Embodiment 1: the manufacture method of donkey-hide gelatin preparation

[0147] (1) Material preparation: 200kg of main ingredients (6 parts of donkey-hide gelatin, 7 parts of hawthorn, 2 parts of wolfberry, 2 parts of jujube), auxiliary materials (100 kg of xylitol, 150 kg of hydrogenated vegetable oil, 10 kg of lecithin)

[0148] (2) Slurry preparation: refinement first - using semi-dry method, roller grinding method (see Figure 6). Specifically: crush 200kg of main ingredients to 100-200 meshes, add 100kg of xylitol and 90kg of hydrogenated vegetable oil (36-60°C) and mix them, and pre-grind them in a two-roll mill (or three-roll mill) to 60-150 microns , and then enter the five-roll mill (or three-roll mill) for grinding to 20-33 microns. Liquefaction—put the material into a refiner (blender) for refining (stirring) for 3 to 6 hours, during which the remaining hydrogenated vegetable oil and lecithin are gradually added according to the viscosity of the material ...

Embodiment 2

[0150] Embodiment 2: the manufacture method of deer horn glue preparation

[0151] (1) Material preparation: 200kg of main ingredients (9 parts of deer horn glue, 1 part of microcrystalline cellulose), auxiliary materials (300kg of sugar, 300kg of refined vegetable oil, 10kg of lecithin)

[0152] (2) Slurry preparation: refinement and liquefaction at the same time - using wet method and fine grinding method (see Figure 7 ). Specifically: mix and grind 200kg of the main ingredients to 15-200 meshes, add 300kg of sugar powder and 270kg of refined vegetable oil (38-60°C) successively (or add them after mixing) and grind them to 26-30 microns. Reserve 30kg of refined vegetable oil and add it together with lecithin 1 hour before the end.

[0153] (3) Molding: after fine grinding, the material is discharged, poured into the preformed aluminum-plastic mold and sealed, cooled and shaped, 10g / piece.

Embodiment 3

[0154] Embodiment 3: the manufacture method of tortoise shell gum preparation

[0155] (1) Materials: 200kg tortoise shell glue, auxiliary materials (200kg isomalt, 100kg lactose, 300kg cocoa butter, 10kg lecithin)

[0156] (2) Slurry preparation: refinement and liquefaction at the same time -: wet method, ball milling method (see Figure 8 ). Specifically: crush 200kg of tortoise shell gum to 10-200 mesh, add 200kg of isomalt, 100kg of lactose and 300kg of cocoa butter (39-60°C) successively (or add after mixing) into a ball mill and grind to 30-33 microns . Lecithin is added successively during the grinding process.

[0157] (3) Molding: Discharge after ball milling, pour into a pre-set mold after temperature adjustment, then cool and solidify, take out the package, 10g / piece.

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Abstract

The invention relates to a mouth immediate-release preparation of a traditional Chinese medicine jelly, and a preparation method thereof. Basic raw materials of the preparation include a main material and a subsidiary material. The main material is mainly jelly, and the subsidiary material is mainly oil dispersant and can be added with water-soluble dispersant, flavoring and surface active agent when necessary; and the weight percentage of the main material is 0.1 percent to 80 percent, and the weight percentage of the subsidiary material is 20 percent to 99.9 percent. The detail operating steps are as below: (1) preparation of the materials; (2) preparation of a sizing agent: thinning and liquefying are included, final fineness of the thinning is less than 600 microns in the case of 70 percent of the preparation by weight, the liquefying is that solid grains are dispersed in the oil dispersant by means of mixing, and the weight percentage of the addition of the oil dispersant meets the condition that oil content in a finished product is not less than 15 percent; and (3) formation: the finished preparation is obtained by adopting a cooling forming method or a powder forming method. The mouth immediate-release preparation improves the dispersing speed of the traditional Chinese medicine jelly in the mouth in the precondition of good mouth taste, no water drinking is needed, andthe taking of the mouth immediate-release preparation is convenient.

Description

(1) Technical field: [0001] The invention provides a traditional Chinese medicine gel oral quick-release preparation and a manufacturing method thereof, the main raw material of which is a gel Chinese medicinal material, which belongs to the technical field of medicine, food and health food preparations. (two) background technology: [0002] Donkey-hide gelatin, also known as basin cover glue, Fuzhi glue, donkey skin glue (or donkey glue), is called donkey-hide gelatin because it is produced in Dong'e County, Shandong Province and boiled with water from Ajing. Because it is made from the skin of animals, it is called a product of flesh and blood in Chinese medicine. The production and medicinal use of donkey-hide gelatin has a history of more than 2,000 years. It has been proved that donkey-hide gelatin is a treasure of blood. [0003] This product was first recorded in "Shen Nong's Materia Medica" and listed as top grade. "Famous Doctors" records: "Ejiao was born in Dongp...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K47/44A61K35/36A61K35/32A61K35/56A61K35/586A61K35/60
Inventor 何煜
Owner 何煜
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