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Method for preparing colon positioning compression-coated tablets

A colon positioning and chip-packing technology, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, drug delivery, etc., can solve the problems of early release of drugs, rapid expansion in contact with water, etc., and achieves low price, simple preparation process, A wide range of effects

Inactive Publication Date: 2009-05-20
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of konjac glucomannan alone has disadvantages such as too fast expansion in water, which will lead to early release of the drug

Method used

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  • Method for preparing colon positioning compression-coated tablets
  • Method for preparing colon positioning compression-coated tablets
  • Method for preparing colon positioning compression-coated tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A method for preparing a colon-positioned compressed package chip, comprising the following steps:

[0025] (1) Preparation of colon-positioned compressed package chip wrapping material: take 40% blended polysaccharide (KGM:XG=7:3) by weight percentage, and mix 60% lactose to obtain mixture 1; will account for mixture 1 weight Add 30% of water into mixture 1 for wet granulation, dry to constant weight, pass through a 20-mesh sieve for granulation; then mix evenly with talcum powder accounting for 1% of the granule weight after granulation, and 3% magnesium stearate to obtain Colon positioning pressing package chip wrapping material;

[0026] (2) Preparation of drug-containing disintegrating tablet core: take 90% raw material drug and 10% sodium starch glycolate by weight percentage, and mix uniformly to obtain mixture 2; add water accounting for 20% by weight of mixture 2 to mixture 2 Wet granulation, drying to constant weight, passing through a 20-mesh sieve for granu...

Embodiment 2

[0030] Prepare three copies of colon-targeted compressed package chips with different proportions of blended polysaccharides, and the preparation steps of each copy are as follows:

[0031](1) Preparation of colon-positioned compression package chip wrapping material: take 40% blended polysaccharide (KGM:XG ratios are 3:7, 5:5 and 7:3 respectively) and 60% lactose by weight percentage Obtain mixture 1 evenly; add water accounting for 30% of the weight of mixture 1 into mixture 1 for wet granulation, dry to constant weight, pass through a 20-mesh sieve for granulation; The magnesium stearate is mixed uniformly to obtain the colon-positioning pressing package chip wrapping material;

[0032] (2) Preparation of drug-containing disintegrating tablet core: take 90% raw material drug and 10% sodium starch glycolate by weight percentage, and mix uniformly to obtain mixture 2; add water accounting for 20% by weight of mixture 2 to mixture 2 Wet granulation, drying to constant weight,...

Embodiment 3

[0038] Prepare three copies of colon-targeted compressed package chips with different lactose contents, and the preparation steps of each part are as follows:

[0039] (1) Preparation of the colon-positioned compression package chip wrapping material: the blended polysaccharide (KGM:XG=3:7) is 40%, 35% and 30% respectively, and the lactose is 60% and 65% respectively according to the weight percentage Mix with 70% evenly to obtain mixture 1; add 30% of the weight of mixture 1 to the mixture 1 for wet granulation, dry to constant weight, pass through a 20-mesh sieve for granulation; and then add 1% of talc powder, and 3% magnesium stearate are mixed evenly to obtain the colon-positioned pressing package chip wrapping material;

[0040] (2) Preparation of drug-containing disintegrating tablet core: take 90% raw material drug and 10% sodium starch glycolate by weight percentage, and mix uniformly to obtain mixture 2; add water accounting for 20% by weight of mixture 2 to mixture ...

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PUM

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Abstract

The invention discloses a method for preparing a colon-specific pressed coated tablet. The method comprises the following steps: (1) mixing Konjac Glucomannan, xanthan gum or carrageenan and a diluting agent; adding an adhesive to the mixture, pelletizing the mixture by a wet method, drying the mixture until constant weight, finishing pellets, and adding a lubricating agent to the mixture to evenly mix, so as to obtain a coating material of the colon-specific pressed coated tablet; (2) evenly mixing bulk drugs and a disintegrant, adding an adhesive to the mixture, pelletizing the mixture by the wet method, drying the mixture until constant weight, finishing pellets, and adding the lubricating agent to the mixture to evenly mix, so as to obtain a drug-contained tablet core; and (3) coating the coating material of the colon-specific pressed coated tablet outside the drug-contained tablet core to be prepared into the colon-specific pressed coated tablet. The colon-specific pressed coated tablet prepared by the method has the characteristic of obvious colon-specific release effect, can conveniently regulate the release process of the tablet through changing the thickness of a coating outer layer, the proportion of blending amylose and the content of the diluting agent. The method has the advantages of wide drug loading system, wide raw material source, low price and simple preparation process.

Description

technical field [0001] The invention relates to a method for preparing a colon-positioned pressing bag chip by using a blended polysaccharide, which belongs to the application technology of new auxiliary materials. Background technique [0002] Oral colon-specific drug delivery system (OCDDS) is a method that uses physical or chemical means to make the drug not release the drug in the upper gastrointestinal tract after oral administration, but starts to release the drug after reaching the ileocecal or colon of the human body. method of administration. The development of OCDDS is widely used in the treatment of localized colonic lesions. In addition, some protein drugs (such as insulin, etc.) are easily inactivated in the stomach and small intestine due to the influence of digestive enzymes, and some drugs (such as anticancer drugs, etc.) have severe stimulation and toxic side effects on the gastrointestinal tract, making OCDDS research has become a hot topic. At present, ...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K47/36A61K47/38
Inventor 王康范江洋何志敏
Owner TIANJIN UNIV
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