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Method for stabilization of reduced coenzyme Q10

A technology of reduced and oxidized coenzymes, applied in chemical instruments and methods, microcapsules, pharmaceutical formulations, etc., can solve the problem of high toxicity and achieve the effect of low possibility and high safety

Active Publication Date: 2009-05-13
KANEKA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dehydroascorbic acid or oxalic acid produced by its decomposition is different from ascorbic acid and highly harmful

Method used

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  • Method for stabilization of reduced coenzyme Q10
  • Method for stabilization of reduced coenzyme Q10

Examples

Experimental program
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preparation example Construction

[0066] In addition, the preparation method of the present invention comprises containing oxidized coenzyme Q 9 (relative to oxidized coenzyme Q 10 not less than 0.6% by weight) and / or oxidized coenzyme Q 11 oxidized coenzyme Q 10 Steps to restore. Through this step, the reduced coenzyme Q containing coenzyme Q that coexists with (a) and / or (b) can finally be obtained 10 Compositions.

[0067] Of course, can contain oxidized coenzyme Q 9 and / or oxidized coenzyme Q 11 oxidized coenzyme Q 10 The reduction method (step) and the reduced coenzyme Q prepared separately 9 and / or reduced coenzyme Q11 The methods (steps) for adding are adopted in combination.

[0068] Co-existing reduced coenzyme Q described in the present invention 9 and / or reduced coenzyme Q 11 reduced coenzyme Q 10 The form of the composition is not particularly limited, and may be crystals; dissolved or suspended in a solvent; a melt at not lower than the melting point; or a form for administration to mam...

Embodiment

[0120] The present invention is illustrated in detail by the following examples, but is not limited thereto.

[0121] In an embodiment, reduced coenzyme Q 10 Purity, reduced coenzyme Q 10 and oxidized coenzyme Q 10 The weight ratio of is determined by HPLC analysis described below. However, the resulting reduced coenzyme Q 10 The purity does not limit the limit value of the purity of the present invention, the same, reduced coenzyme Q 10 and oxidized coenzyme Q 10 The weight ratio of reduced coenzyme Q in 10 The ratio does not limit its upper limit.

[0122] (HPLC analysis conditions)

[0123] Column: SYMMETRY C18 (manufactured by Waters) 250 mm (length) 4.6 mm (inner diameter), mobile phase: C 2 h 5 OH:CH 3 OH=4:3(v:v), detection wavelength: 210nm, flow rate: 1ml / min, reduced coenzyme Q 10 Retention time: 9.1min, oxidized coenzyme Q 10 Retention time: 13.3min.

preparation example 1

[0125] oxidized coenzyme Q 10 (100 g) and L-ascorbic acid (60 g) were added to 1000 g of ethanol, and the mixture was stirred at 78° C. to perform a reduction reaction. After 30 hours, the mixture was cooled to 50°C, and 400 g of ethanol was added maintaining the same temperature. This ethanol solution (containing 100g reduced coenzyme Q 10 ) was cooled to 2° C. with stirring at a cooling rate of 10° C. / hour to obtain a white slurry. The resulting slurry was filtered under reduced pressure, and the wet crystals were washed with cold ethanol, cold water, and cold ethanol in sequence (the temperature of the cold solvent used for washing was 2° C.), and dried under reduced pressure (20-40° C., 1- 30mmHg) to obtain white dry crystals (95g). All manipulations were performed under nitrogen atmosphere except drying under reduced pressure. Reduced coenzyme Q in the resulting crystals 10 / oxidized coenzyme Q 10 The weight ratio is 99.4 / 0.6.

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Abstract

Disclosed are a method and a composition for stabilizing a reduced coenzyme Q10 which is useful as a food, a food with a nutrient function, a food for specified health uses, a nutritional supplement, a nutritional product, a veterinary drug, a beverage, a feeding stuff, a cosmetic, a pharmaceutical product, a therapeutic agent, a prophylactic agent and the like. The method is characterized by allowing a reduced coenzyme Q10 to coexist with a reduced coenzyme Q9 and / or a reduced coenzyme Q11. The composition comprises a reduced coenzyme Q10 and a reduced coenzyme Q9 and / or a reduced coenzyme Q11.

Description

technical field [0001] The present invention relates to stable reduced coenzyme Q 10 method, and containing reduced coenzyme Q 10 The composition, the reduced coenzyme Q in the composition 10 It is stable against oxidation. Reduced coenzyme Q 10 compared to oxidized coenzyme Q 10 Showing high oral absorbability, it is used as an excellent food, nutritional functional food, food for specific health use, nutritional supplement, nutritional supplement, animal drug, beverage, feed, pet food, cosmetics, pharmaceuticals, therapeutic drug, preventive Pharmaceutically useful compounds. Background technique [0002] It is known that the following method can obtain reduced coenzyme Q 10 : For example, coenzyme Q is obtained by known methods such as synthesis, fermentation, and extraction from natural substances 10 Afterwards, the reduced coenzyme Q separated in the effluent was separated by chromatography 10 Concentration is performed (Patent Document 1). It is described in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C41/46A23K1/16A23K1/165A61K8/35A61K9/48A61K9/50A61K31/122A61P3/02C07C41/26C07C41/34C07C43/23A23L1/30A61K8/34A61K31/05A61K47/14A61K47/24A61K47/42A61K47/44A61P9/00A61P9/04A61P39/06A61Q19/00
CPCA61K31/00A61K38/43A61K9/4858A61K31/047A61P3/02A61P39/06A61P9/00A61P9/04C07C41/46A61K8/35
Inventor 植田尚宏北村志郎久保博司细江和典
Owner KANEKA CORP
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