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Extraction method for joint production of coptis chinensis with coptis chinensis fibrous root as raw material

A technology of Coptis alkaloids and an extraction method is applied in the field of extracting Coptis alkaloids, can solve problems such as few technical reports on extracting jatrorrhizine and Coptis alkaloids, etc., and achieves the effects of low product cost, low production cost and sufficient resource utilization.

Inactive Publication Date: 2009-05-13
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, although there are many and mature techniques for extracting berberine, the extracted raw materials are mainly three needles or Cortex Phellodendri; there are few reports on the techniques for extracting jatrorrhizine and berberine
Coptidis rhizome root as raw material, simultaneous extraction of jatrorrhizine monomer, berberine monomer and Coptidis compound alkaloid co-production technology, has not been reported yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Add 3 liters of 1% sulfuric acid solution to 1 kg of Coptidis root, heat up to 100°C for reflux extraction for 0.1 hour, filter to obtain the first extract; the residue is then extracted with 3 liters of 1% sulfuric acid solution and heated to 100°C to obtain the first extract For the second extraction, repeat the extraction twice according to the method for the second extraction to obtain the third and fourth extractions respectively; merge the first and second extractions (three extractions and four extractions are used for the next extraction) The processing of batch raw materials); the combined solution is neutralized with milk of lime to the pH=4 of the solution, statically stratified for 3 hours, and filtered; the supernatant is applied to the cation exchange resin according to the speed of 0.001 times the resin volume per minute, after the adsorption is saturated, Fully wash with 10 times the amount of tap water (the washing speed is the same as that of the upper ...

Embodiment 2

[0033] Add 15 liters of 0.05% sulfuric acid solution to 1 kg of Coptidis root, soak at room temperature for 24 hours, filter to obtain the first extract; the residue is then extracted with 10 liters of 0.05% sulfuric acid to obtain the second extract, according to Repeat the extraction twice for the second extraction method to obtain the third and fourth extracts respectively; combine the first and second extracts (three extractions and four extractions are used for the processing of the next batch of raw materials); The combined liquid was neutralized with milk of lime until the pH of the solution was 10, statically stratified for 24 hours, and filtered; the supernatant was applied to the cation exchange resin at a speed of 0.1 times the volume of the resin per minute, and after the adsorption was saturated, it was fully washed with 10 times the amount of tap water (the washing speed is the same as the upper column speed); then use the sodium carbonate-sodium bicarbonate buffe...

Embodiment 3

[0035]Add 10 liters of 0.4% sulfuric acid solution to 1 kg of coptis root, heat up to 60°C for reflux extraction for 1 hour, and filter to obtain the first extract; the residue is then heated to 60°C with 10 liters of 0.4% sulfuric acid solution to obtain the second extract. Second extraction, repeat extraction twice again according to the extraction method for the second time, obtain the third and fourth extraction respectively; Merge the first and second extraction (three extractions and four extractions are used for the next batch of raw materials) treatment); the combined solution was neutralized with milk of lime to the pH=6 of the solution, statically stratified for 12 hours, and filtered; the supernatant was applied to the cation exchange resin at a rate of 0.01 times the volume of the resin per minute, and after adsorption was saturated, 10 times the amount of Fully wash with tap water (the washing speed is the same as the column speed); then use 1mole / L concentration o...

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Abstract

The invention relates to an extraction process technology for the combined production of coptis alkaloid by taking coptis roots as a raw material, which comprises the following process flow: the coptis roots, adding of proper amount of 0.05 to 1 percent sulfuric acid for soaking, precipitate neutralization and impurity removal, entrance to an anion separation column, stepwise elution, separation decolorization of components, recovery of a solvent, fractional precipitation and crystallization, drying, and a jateorrhizine monomer, a jamaicin monomer, and a coptis composite alkaloid. In the process, the contents of the jateorrhizine monomer and the jamaicin monomer are more than 90 percent, and the total alkali content of the composite alkaloid is more than 50 percent. In the extraction process, the efficiency of separation on the column is improved through the operation step of neutralization and impurity removal; the stepwise elution realizes the separation of an alkaloid monomer; and a product realizes the separation of alkaloid through the fractional separation on the column.

Description

technical field [0001] The invention belongs to biological extraction technology, and in particular relates to a process for extracting coptis alkaloids from coptis root. Background technique [0002] Coptis chinensis is bitter in taste and cold in nature. It has the functions of purging fire, detoxifying, clearing away heat and drying dampness. It is listed as the top grade in "Shen Nong's Materia Medica". Shizhu is the main production area of ​​Coptis chinensis in my country. Shizhu Coptis chinensis has completed the acceptance of the GAP standardized cultivation base and obtained the national geographical landmark product. Coptis chinensis in Shizhu produces a large amount of fibrous roots of coptis by-product when it is harvested. The results of modern medicinal chemistry research show that the composition of the active ingredients (alkaloids) of Coptis chinensis is similar to that of Coptis chinensis, and also contains berberine, jatrorrhizine, coptisine and palmatine ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D455/03A61K36/718
Inventor 李学刚叶小利
Owner SOUTHWEST UNIV
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