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Magnesium isoglycyrrhizinate cream and preparation method and use thereof

A magnesium glycyrrhizinate cream and a technology of magnesium isoglycyrrhizinate are applied in the field of external preparations of magnesium isoglycyrrhizinate, which can solve the problems of dry and cracked skin and incompatibility, and achieve the effects of improving compliance and being convenient to use.

Active Publication Date: 2009-05-06
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the gel is easy to cause dry and cracked skin, it is not suitable for topical administration of hypertrophic lichenification such as psoriasis. We have studied other external preparations suitable for the treatment of psoriasis and dermatitis, such as ointment, cream, transdermal patch, Film agent, film coating agent and paint, have overcome above-mentioned defective, thus completed the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Embodiment 1: water-soluble base type ointment

[0075] Prescription (200g):

[0076] Magnesium Isoglycyrrhizinate 2g

[0077] Macrogol 4000 60g

[0078] Macrogol 400 90g

[0079] Water-soluble Azone 4g

[0080] Ethylparaben 0.2g

[0081] 10% ammonia water appropriate amount

[0082] Glycerin 10g

[0083] Distilled water up to 200g

[0084] Preparation method: 1. Dissolve magnesium isoglycyrrhizinate and an appropriate amount of 10% ammonia water in distilled water, dissolve ethylparaben in glycerin, mix well, add water-soluble azone, and stir well.

[0085] 2. Mix polyethylene glycol 4000 and polyethylene glycol 400, heat to about 70°C on a water bath, and stir well.

[0086] 3. Add (1) into (2), add water to 200g, stir until condensed, and you get it.

Embodiment 2

[0087] Embodiment 2: water-in-oil cream

[0088] Prescription (200g):

[0089] Magnesium Isoglycyrrhizinate 2g

[0090] Span 80 4g

[0091] Chlorocresol 0.4g

[0092]Beeswax 15g

[0093] Liquid paraffin 50g

[0094] White Vaseline 10g

[0095] Glyceryl monostearate 30g

[0096] 5% sodium hydroxide appropriate amount

[0097] Distilled water 88g

[0098] Preparation method: 1. Put beeswax, glyceryl monostearate, liquid paraffin, white vaseline and Span 80 into the oil phase, put it in an evaporating dish, and heat it to about 80°C on a water bath.

[0099] 2. Dissolve magnesium isoglycyrrhizinate plus an appropriate amount of 5% sodium hydroxide in distilled water, add chlorocresol, heat to about 80°C on a water bath, stir to dissolve, and form a water phase.

[0100] 3. Slowly add the water phase into the oil phase at about 80°C, and keep stirring on a water bath until it becomes a milky white semi-solid, and then stir at room temperature until it is nearly condensed....

Embodiment 3

[0101] Embodiment 3: Filled closed type magnesium isoglycyrrhizinate transdermal patch

[0102] The patch described in this embodiment is composed of a backing layer, a drug storage layer, a release-controlling film, an adhesive layer and a protective layer. The materials used for each layer are as follows:

[0103] Backing layer: aluminum foil / polyethylene composite film

[0104] Protective layer: polyester film

[0105] Controlled Release Membrane: Ethylene-vinyl acetate copolymer membrane

[0106] Adhesive layer: silicone pressure sensitive adhesive

[0107] Drug storage layer (200g):

[0108] Magnesium Isoglycyrrhizinate 20g

[0109] Carbomer 4g

[0110] Appropriate amount of triethanolamine

[0111] Glycerin 20g

[0112] Azone 4g

[0113] 5% sodium hydroxide appropriate amount

[0114] Distilled water up to 200g

[0115] Preparation method:

[0116] 1. Prepare the drug storage layer:

[0117] (1) Slowly add carbomer to 50% distilled water under stirring to ma...

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PUM

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Abstract

The invention relates to a magnesium isoglycyrrhetate emulsifiable paste preparation which contains the magnesium isoglycyrrhetate, a water-in-oil type substrate and a pH regulator; wherein, the weight of the magnesium isoglycyrrhetate accounts for 1 to 10 percent and the pH value is 6.5 to 8; an emulsifier used in the water-in-oil type substrate is span 80 and monostearin.

Description

[0001] This application is a divisional application of an invention patent application with an application date of September 28, 2005, an application number of 200510106110.7, and an invention title of "magnesium isoglycyrrhizinate external preparation and its preparation method and application". technical field [0002] The invention relates to an external preparation of magnesium isoglycyrrhizinate, including ointment, cream, transdermal patch, film, film coating and paint, as well as its preparation method and application in medicine. technical background [0003] Glycyrrhizic acid has pharmacological effects such as anti-inflammation, anti-allergy, immune regulation, anti-biological oxidation and inhibition of mutation. Clinically, diammonium glycyrrhizinate has been administered intravenously to treat psoriasis and dermatitis, such as eczema, and has a good effect. Oral preparations of glycyrrhizic acid, such as compound glycyrrhizin tablets (trade name Meineng), are al...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/704A61P17/06A61P17/00A61P37/08
Inventor 程艳菊张来芳张喜全
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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