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Polymer electrostatic spinning film, preparation and use in biological detection

An electrospinning and polymer technology, which is applied in the field of polymer electrospinning film and its preparation, and the post-processing field of polymer electrospinning, can solve the problems that cannot be directly applied and difficult to operate, and achieve low production cost, Low cost, uniform thickness

Active Publication Date: 2009-04-22
BEIJING NANO ACE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of spinning, due to the electrostatic repulsion of the spinning belts, the obtained electrospun non-woven fabrics generally have a very fluffy structure, which is difficult to operate and cannot be used directly.

Method used

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  • Polymer electrostatic spinning film, preparation and use in biological detection
  • Polymer electrostatic spinning film, preparation and use in biological detection
  • Polymer electrostatic spinning film, preparation and use in biological detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Use as attached figure 1 The electrospinning device shown in the electrospinning device adopts the method involved in the present invention to carry out electrospinning, and its flow process is as follows Figure 5 As shown, the prepared polycarbonate (PC) electrospun film is as follows figure 2 , 4 shown. Specific steps are as follows:

[0045]a). Prepare a polycarbonate solution for electrospinning, dissolve 20g polycarbonate in 80g chloroform to obtain a 20wt% polycarbonate solution, and carry out electrospinning with this solution. During electrospinning, the prepared The polycarbonate spinning solution 1-2 is contained in the spinning tube 1-1, and the spinning solution is propelled by a syringe pump; the distance between the spinning nozzle 1-3 and the surface receiving the aluminum foil 5-2 is 10 cm, and the spinning nozzle 1-3 3 Connect the positive pole of the high voltage generator 1-4 as the anode, accept the aluminum foil 5-2 and connect the negative po...

Embodiment 2

[0051] The polystyrene (PS) electrostatic spinning film is prepared by adopting the method involved in the invention. Specific steps such as

[0052] Down:

[0053] a). Prepare polystyrene solution for electrospinning, dissolve 14g polystyrene in 86g dimethylformamide (DMF), prepare 14wt% polystyrene solution, carry out electrospinning with this solution, apply The voltage was 10-30kV, and electrospinning was performed for 15 minutes. During the electrospinning process, the polystyrene solution is formed into nanofibers under the action of an electric field, with an average spinning diameter of 200 nm and a film thickness of 15 μm;

[0054] b). Place the fluffy polystyrene spinning film obtained in step a) flatly on the platform, cover the polystyrene spinning film with aluminum foil, and apply a weight on it with a pressure of 600Pa. The pressure was maintained for 5 hours, the flat polystyrene spun film obtained by removing the weight and covering the spun aluminum foil; ...

Embodiment 3

[0059] The polymethyl methacrylate (PMMA) electrostatic spinning film is prepared by adopting the method involved in the invention.

[0060] Specific steps are as follows:

[0061] a). Prepare a polymethyl methacrylate solution for electrospinning, dissolve 10g polymethyl methacrylate in 90g tetrahydrofuran (THF), and prepare a 10wt% polymethyl methacrylate solution. Perform electrospinning, apply a voltage of 10-30 kV, and electrospin for 20 minutes. During the electrospinning process, the polymethyl methacrylate solution is formed into nanofibers under the action of an electric field, with an average spinning diameter of 300 nm and a film thickness of 15 μm;

[0062] b). Place the fluffy polymethyl methacrylate spinning film obtained in step a) flatly on the platform, cover the polymethyl methacrylate spinning film with aluminum foil, and apply a weight on it with a pressure of 600Pa. The pressure was maintained for 5 hours, and the heavy objects were removed and the alumi...

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Abstract

The invention relates to a macromolecular electrostatic spinning film, a preparation method thereof and an application of the macromolecular electrostatic spinning film to bioinstrumentation. The macromolecular electrostatic spinning film is a membranoid substance which is formed by disorderly interlacing macromolecular electrostatic spinning which are not water-soluble; and the diameter of the macromolecular electrostatic spinning is between 50 and 1,000 nanometers, and the thickness of the film is between 5 mu m and 1 millimeter. The preparation method comprises the following steps: electrostatic spinning is performed in an electrostatic spinning device, and the spinning obtained is subjected to pressing, waterlogging and secondary pressing to obtain the dense and smooth macromolecular electrostatic spinning film with strong operability. The film can be applied to bioinstrumentation and taken as a protein absorbing vector, and has a larger absorption quantity compared with the prior protein absorbing vector film. The preparation method for the film is simple, has low cost, can solve the problems that the electrostatic spinning is puffy, unsmooth and easy to fall off, converts electrostatic spinning non-woven fabrics into the electrostatic spinning film used for bioinstrumentation, and can also be applied in the fields of tissue engineering, bioinstrumentation, catalyst load, filter materials and so on.

Description

technical field [0001] The present invention relates to a polymer electrospinning film and its preparation method, in particular to a post-processing method of water-insoluble polymer electrospinning to obtain a flat and dense electrospinning film, which can be used for biological detection. Background technique [0002] Electrospinning technology is widely used to prepare polymer fiber non-woven fabrics. This method has simple equipment and low cost. This non-woven fabric has a large specific surface area and a large porosity. It has good performance in many aspects. Applications, such as in biological detection, tissue culture, medical bandages and other fields. (References: D. Li, Y. Xia, Adv. Mater. 2004, 16, 1151). Polymer materials have been widely used in biological detection, such as in the adsorption of proteins. Traditional protein adsorption carriers include nitrocellulose membrane (NC membrane) and diazobenzyloxymethylcellulose paper (DBM paper). , Nylon membr...

Claims

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Application Information

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IPC IPC(8): D04H3/10D01D5/00D01F6/06D01F6/04D01F6/18D01F6/62D01F6/64G01N33/53G01N21/64D04H1/4291D04H1/43D04H1/435D04H1/728
Inventor 蒋兴宇仰大勇牛鑫刘颖昳宋炉胜
Owner BEIJING NANO ACE TECH CO LTD
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