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Novel use of salvia root extract

A technology for extracts and uses, applied in the field of new uses of salvia miltiorrhiza extracts, can solve problems such as less research

Inactive Publication Date: 2009-04-22
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In summary, although it has been reported that Danshen has the function of protecting the heart, previous studies were mostly limited to the protection of Danshen on myocardial ischemia or myocardial ischemia-reperfusion and its mechanism. Myocardial toxicity due to doxorubicin has been less studied

Method used

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  • Novel use of salvia root extract
  • Novel use of salvia root extract
  • Novel use of salvia root extract

Examples

Experimental program
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Effect test

preparation example Construction

[0040] The preparation method of Salvia miltiorrhiza extract can adopt the method known to those skilled in the art, such as the method of extracting from plants, or the method of chemical synthesis. Preferably, the method of direct extraction from plants can be used.

[0041] use

[0042] The present invention provides the use of salvia miltiorrhiza extract for preparing a composition for reducing the formation of myocardial vacuoles.

[0043] Myocardial vacuolation is a factor that produces myocardial damage, which is caused by protein degradation. The salvia miltiorrhiza extract described herein can prevent the formation of myocardial vacuoles to avoid myocardial damage or alleviate the degree of myocardial damage.

[0044] In addition, the salvia miltiorrhiza extract can also be used for: inhibiting the weight loss of mammals caused by doxorubicin; inhibiting the weight loss of mammalian hearts; improving mammalian bradycardia; or reducing the content of creatine kinase, ...

Embodiment 1

[0067] Protective effect of salvianolic acid on doxorubicin-induced cardiotoxicity in mice

[0068] In this example, the cardioprotective effect of salvianolic acid was studied.

[0069] animal

[0070] Clean grade KM mice, body weight 20g±2, male. Purchased from Shanghai Laboratory Animal Center, Chinese Academy of Sciences.

[0071] reagent

[0072] Salvianolic acid (SA) extraction method: 100-mesh salvia powder sample (purchased from Pingyi Salvia plantation base, Shandong) 30g, dissolved in 70% ethanol (1000ml), refluxed for 1 hour, and the extraction amount was determined by weight loss method.

[0073] Identification of salvianolic acid: The extract was filtered with a 0.45 μm microporous membrane, and identified by Agilent 1100 HPLCsystem (Agilent Technologies, Palo Alto, CA, USA). The obtained liquid chromatogram is shown in figure 1 shown.

[0074] Doxorubicin (doxorubicin hydrochloride for injection): purchased from Zhejiang Hisun Pharmaceutical Co., Ltd., batch...

Embodiment 2

[0093] Protective effect of tanshinone IIA sodium sulfonate injection on doxorubicin-induced cardiotoxicity in mice

[0094] In this example, the cardioprotective effect of tanshinone IIA sodium sulfonate injection was studied.

[0095] animal

[0096] Clean grade KM mice, body weight 20g±2, male. Purchased from Shanghai Laboratory Animal Center, Chinese Academy of Sciences.

[0097] reagent

[0098] Tanshinone IIA Sodium Sulfonate Injection: purchased from Shanghai No. 1 Biochemical Pharmaceutical Co., Ltd., batch number 070701.

[0099] Doxorubicin (doxorubicin hydrochloride for injection): purchased from Zhejiang Hisun Pharmaceutical Co., Ltd., batch number 061102.

[0100] experimental method

[0101] Fifty-four KM mice, weighing 20g ± 2g, male, were randomly divided into four groups after being adapted to feeding for 3 days:

[0102] Normal group (Control, n=13);

[0103] Doxorubicin group (DXR, n=15);

[0104] 5mg / kg tanshinone IIA sodium sulfonate group (low dos...

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Abstract

The invention belongs to the field of pharmacology and discloses novel application of radix salviae miltiorrhizae extract. The radix salviae miltiorrhizae extract is used for preparing a composition for reducing myocardial vacuolation. The inventor accidentally finds out that the radix salviae miltiorrhizae extract has superior effect on reducing myocardial vacuolation and has no side effect. The radix salviae miltiorrhizae extract can be combined with adriamycin for use, and greatly reduce the toxic and side effect after application of the adriamycin, so that the radix salviae miltiorrhizae extract can inhibit tumor and simultaneously reduce myocardial vacuolation.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and more particularly, the invention relates to a new use of Salvia miltiorrhiza extract. Background technique [0002] Salvia miltiorrhiza Bunge is the root and rhizome of Salvia miltiorrhiza Bge. Its chemical composition contains tanshinone I, IIA, IIB (tanshinone I, IIA, IIB) isotanshinone I, IIA (isotanshinone I, IIA), cryptotanshinone (cryptotanshinone), isocryptotanshinone (isocryptotanshin-one), methyl tanshinone (methyItanshinone), Hydroxytanshinone, etc. In traditional Chinese medicine, Salvia miltiorrhiza functions and treats mainly: dispelling blood stasis and relieving pain, promoting blood circulation and clearing meridians, clearing the heart and eliminating vexation. It is used for irregular menstruation, amenorrhea dysmenorrhea, accumulation of Zhengjia, tingling pain in the chest and abdomen, heat pain, sore swelling and pain, hepatosplenomegaly, angina pectoris. [0003] Acc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K31/704A61P9/00A61P35/00A61K31/343A61K125/00
Inventor 果德安姜宝红吴婉莹
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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