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Medical composition containing meptazinol hydrochloride

A technology of meptafol and its composition, which is applied in the field of oral solid pharmaceutical compositions, can solve the problems of difficult preparation of stable oral pharmaceutical preparations, insufficient stability of meptafol, etc., and achieve cheap, easy-to-obtain and good Stability, the effect of good production process

Inactive Publication Date: 2009-03-25
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mebutanol is not stable enough to prepare stable oral pharmaceutical preparations for clinical use

Method used

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  • Medical composition containing meptazinol hydrochloride
  • Medical composition containing meptazinol hydrochloride
  • Medical composition containing meptazinol hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015]

[0016] Preparation:

[0017] Weigh the prescribed amount of mabutamol hydrochloride and stearic acid and mix evenly at high speed, then mix evenly with microcrystalline cellulose, lactose, and crospovidone, use water-based soft materials, granulate with 18 mesh, and oven at 50°C Dry, granulate with 24-mesh sieve, add externally, mix evenly, and press into tablets.

Embodiment 2

[0019]

[0020] Preparation:

[0021] Weigh the prescribed amount of mabutaol hydrochloride and stearic acid and then mix them evenly with microcrystalline cellulose, pregelatinized starch and croscarmellose sodium, and use 8% pregelatinized starch slurry to make soft material, granulated with 18 mesh, oven-dried at 50°C, granulated with 30 mesh sieve, added with talcum powder, mixed evenly, and packed into capsules.

Embodiment 3

[0023]

[0024] Preparation:

[0025] Weigh the prescribed amount of meprotamol hydrochloride and stearic acid and mix them evenly at high speed, then mix them evenly with microcrystalline cellulose, starch and polacrilin potassium, use 10% starch slurry to make soft material, granulate with 18 mesh, 50 Oven-dried at ℃, granulated with a 30-mesh sieve, added with micro-powdered silica gel, mixed evenly, and packed into capsules.

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PUM

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Abstract

The invention discloses a stable oral-taking solid medicine combination which contains meptazinol with effective treatment dosage, salt, organic acid and medicinal auxiliary material. The stable oral-taking solid medicine combination is used for the clinical treatments of intermediate pain, trauma, postoperative pain, obstetrical pain and renal colic.

Description

technical field [0001] The present invention relates to a stable oral solid pharmaceutical composition, especially a pharmaceutical composition containing effective therapeutic dose of meptafol. Background technique [0002] Pain is a common clinical disease, which is mainly caused by cancer, surgery and trauma. Most of the analgesics currently used in clinical practice are accompanied by addiction. In contrast, meprotamol has less side effects and is an ideal substitute product. Meptazinol is a partial agonist of opioid receptors. It has significant analgesic effect. It is often used for moderate or severe pain caused by different reasons. Its analgesic activity is equivalent to that of pentazocine and meptazine. Compared with other opioid analgesics, phenol has less side effects such as respiratory depression and withdrawal addiction, and the dose of inhibiting breathing is 1.8 times that of meperidine. Mainly used for moderate pain, trauma, postoperative, obstetric pain ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/55A61P25/04
Inventor 岳本花
Owner BEIJING D VENTUREPHARM TECH DEV
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