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Alficetin soft capsules

A technology of chloramphenicol and soft capsule, which is applied in the field of external medicine for the treatment of vaginitis, can solve the problems of hardening of the capsule shell, affecting the drug release rate, and high toxicity of polyethylene glycol, and achieves good uniformity, beautiful appearance, and human body less toxic effect

Active Publication Date: 2009-01-21
SUNSHINE LAKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The document whose application number is 200410010643.0 discloses a medicine for treating bacterial vaginosis and its preparation method, wherein polyethylene glycol 400 is used as a soft capsule filler, but due to the difference in the molecular weight of polyethylene glycol, it is selectively absorbed in the capsule shell Moisture is also different, resulting in different hardening of the capsule shell, which affects the rate of drug release
Also, low molecular weight polyethylene glycols are the most toxic

Method used

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  • Alficetin soft capsules

Examples

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Effect test

Embodiment 1

[0032] 1. Chloramphenicol soft capsules, the content of each 1000 soft capsules is prepared from the following parts by mass:

[0033] Chloramphenicol 50g

[0034] 1.2-Propanediol 140g

[0035] Macrogol 600 60g

[0036] Wherein, the chloramphenicol according to C 11 h 12 Cl 2 N 2 o 5 count:

[0037] The gelatin liquid formula of described capsule is:

[0038] Gelatin: glycerin: water = 0.9: 0.5: 1.1.

[0039] Two, the preparation method is as follows:

[0040] 1. Preparation of gelatin solution:

[0041] Gelatin: glycerin: water = 0.9: 0.5: 1.1

[0042] Add weighed purified water and glycerin into a clean glue mixing tank, heat to about 50°C, keep warm, start stirring, add gelatin while stirring, seal the glue mixing tank, wait until the gelatin is completely swollen and dissolved, turn off the stirring , turn on the vacuum pump, evacuate, and remove the air bubbles in the gelatin solution. Leave for about 1 hour until the air bubbles in the gelatin solution are c...

Embodiment 2

[0053] 1. Chloramphenicol soft capsules, the content of each 1000 soft capsules is prepared from the following parts by mass:

[0054] Chloramphenicol 75g

[0055] 1.2-Propanediol 160g

[0056] Macrogol 600 80g

[0057] Wherein, the chloramphenicol according to C 11 h 12 Cl 2 N 2 o 5 count:

[0058] The gelatin liquid formula of described capsule is with embodiment 1;

[0059] Two, preparation method is the same as embodiment 1.

Embodiment 3

[0061] 1. Chloramphenicol soft capsules, the content of each 1000 soft capsules is prepared from the following parts by mass:

[0062] Chloramphenicol 90g

[0063] 1.2-Propanediol 200g

[0064] Macrogol 600 100g

[0065] Wherein, the chloramphenicol according to C 11 h 12 Cl 2 N 2 o 5 count:

[0066] The gelatin liquid formula of described capsule is with embodiment 1;

[0067] Two, preparation method is the same as embodiment 1.

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Abstract

The invention refers to a chloramphenicol vaginal soft capsule. The content of the soft capsule is composed of the following components by weight proportion: 50-200g of chloramphenicol; 140-560g of 1.2-propylene glycol and 60-240g of polyethelene glycol 600; the formula of gelatin liquid is that gelatin: glycerol: water is equal to 0.5-1.5:0.4-0.6:0.5-1.5; the preparation method and the formula are scientific and precise, and the dosage form is novel. Compared with suppository, the soft capsule is characterized by higher bioavailability, accurate content, good uniformity and beautiful appearance, which is especially applied to the treatment of bacterial vaginitis, trichomonal vaginitis, colpitis mycotica and senile vaginitis.

Description

technical field [0001] The invention relates to the field of external medicines for treating vaginitis, in particular to chloramphenicol soft capsules. Background technique [0002] Vaginitis is an inflammation of the vaginal mucosa and submucosal connective tissue, and is a common disease in gynecological clinics. [0003] The most effective drugs for treating bacterial vaginosis are mostly metronidazole or tinidazole, which are sensitive to most anaerobic bacteria in the vagina, and reduce the pH of the vagina to inhibit the growth and reproduction of Gardnerella vaginalis. However, studies have shown that: chloramphenicol has a broad-spectrum antibacterial effect, and its effect on gram-negative bacilli such as influenza bacillus and Salmonella is stronger than that of gram-positive bacteria such as staphylococcus; chloramphenicol is still effective against anaerobic bacteria, including fragile Bacteroides, etc. are also effective; it also has antimicrobial effects on Ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61K9/48A61K47/34A61K47/42A61P15/02A61P31/04A61P33/02A61P31/10A61K47/10
Inventor 王超志
Owner SUNSHINE LAKE PHARM CO LTD
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