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Composite coating magnesium/magnesium alloy biology device and preparation method thereof

A biomedical and composite coating technology, applied in coatings, medical science, blood vessels, etc., can solve the problems of degradation time and strength, disproportionate rigidity, poor controllability of degradation, poor processing stability, etc., to avoid premature failure, The effect of preventing surface degradation and less damage

Active Publication Date: 2009-01-07
LEPU MEDICAL TECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when used as a scaffold, degradable polymer materials have the following problems: 1. Low strength, low hardness and rigidity; The device fails prematurely; 3. The processing stability is poor, and the processing of degradable polymer materials requires special processing environment and equipment

Method used

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  • Composite coating magnesium/magnesium alloy biology device and preparation method thereof
  • Composite coating magnesium/magnesium alloy biology device and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] The preparation method of the composite coating magnesium alloy medical stent mainly includes 1) the processing and preparation of the magnesium alloy stent; 2) the coating of the degradable polymer film on the surface of the magnesium alloy; 3) the preparation of the iron film by magnetron sputtering.

[0038] After the AZ31B magnesium alloy is polished, it is laser-engraved into a vascular stent. Then cleaning includes (1) cleaning with a medical ethanol solvent with a concentration of 75%; (2) cleaning with an analytically pure acetone solution with a concentration of 99.5%; (3) cleaning with deionized water in an ultrasonic wave with an ultrasonic frequency of 50khz. The cleaning time of each step is 10 minutes, and the cleaned bracket is placed in a dryer to dry.

[0039] Use tetrahydrofuran as a solvent to dissolve the degradable polymer PLGA with a concentration of 1.5% (mass percentage), shake it evenly with a shaker, spray it on the surface of the dried magnesi...

Embodiment 2

[0043] After the AZ91D magnesium alloy is polished, it is laser engraved into a vascular stent. Then cleaning, including (1) cleaning with a medical ethanol solvent with a concentration of 75%; (2) cleaning with acetone analytically pure solution with a concentration of 99.5%; (3) cleaning with deionized water in an ultrasonic wave with an ultrasonic frequency of 28 ~100khz. The cleaning time of each step is 10 minutes, and the cleaned bracket is placed in a dryer to dry.

[0044] Use chloroform as a solvent to dissolve the degradable polymer poly-L-lactic acid (PLLA), with a concentration of 1.5% (mass percentage), shake it evenly with a shaker, spray it on the surface of the magnesium alloy stent after cleaning, and let it dry naturally in the air. Put it into the LGJ-12 vacuum freeze dryer, negative pressure the polymer film layer for 30 minutes, and the negative pressure value is 6 Pascals. The number of times of spraying is determined by the thickness of the coating, an...

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Abstract

The invention relates to a magnesium / magnesium alloy biomedical appliance with compound coating and the preparation method thereof. The biomedical appliance comprises a magnesium / magnesium alloy matrix (1), a film (2) made of degradable high-polymer material on the surface of the magnesium / magnesium alloy matrix and an iron film (3) on the surface of the degradable high-polymer material; the preparation method comprises the following steps: firstly, the magnesium / magnesium alloy material is processed into a biomedical appliance in specific shape; secondly, the degradable polymer film is coated; and thirdly, the iron film is plated through magnetron sputtering. The magnesium / magnesium alloy biomedical appliance with compound coating has the advantages that not only the superior performances of metallic material and degradable high polymer material are maintained, but also the service life of the appliance is effectively prolonged, the operation is safe, and the medical clinical needs are met.

Description

technical field [0001] The invention relates to the field of biomedical devices, in particular to a magnesium / magnesium alloy medical device with a composite coating and a preparation method thereof. Background technique [0002] In 1964, Dotter (Dotter CT, Judkins MD. Transluminal treatment of arteriosclerotic obatruction: a new technique and a preliminary report of its application [J]. Circulation, 1964, 30: 654) proposed the concept of percutaneous transluminal angioplasty, and proposed The blood vessels are supported with silicone rubber or plastic to keep blood flowing through them. In 1976, German scholar Andrea Gronzgo first proposed the idea of ​​installing stents in arteries. After that, the technology developed rapidly. By the 1990s, coronary stents had been widely used in clinical treatment, and nearly 90% of coronary interventions were performed. Sexual therapy includes implantation of stents. At present, drug-eluting stents based on stainless steel and cobalt-...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/04A61L27/34A61L27/30A61L31/12A61L31/02A61L31/08A61L31/10A61F2/06
Inventor 董飒英钭一伟赵丽晓刘小刚蒲忠杰
Owner LEPU MEDICAL TECH (BEIJING) CO LTD
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