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Agent for amelioration of insulin resistance

An insulin resistance and improving agent technology, which is applied in the fields of plant raw materials, food preparation, food science, etc., can solve the problems of unreported insulin resistance improvement effect of aloe vera, and achieve the effect of safe intake

Active Publication Date: 2008-09-24
MORINAGA MILK IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, an immunosuppression-improving agent (Patent Document 10), substances related to improving blood sugar levels (Patent Documents 11 to 14), and an obesity prevention improving agent (Patent Document 10) that are characterized by containing the butanol component of an aloe extract or aloin have been disclosed. Document 15), etc., but there is no report on the insulin resistance improving effect of Aloe plants

Method used

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  • Agent for amelioration of insulin resistance
  • Agent for amelioration of insulin resistance
  • Agent for amelioration of insulin resistance

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0083] Hereinafter, a production example of 3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol from Aloe vera is given as a production example of a Liliaceae plant.

[0084] 3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol was extracted and purified from Aloe vera as follows.

[0085] 100 kg of mesophyll (transparent gel part) of Aloe vera was liquidized with a homogenizer, and 100 L of ethyl acetate / butanol mixed solution (3:1) was added thereto and stirred. After standing overnight, the ethyl acetate / butanol mixture was separated from the water layer to recover the ethyl acetate / butanol mixture. The ethyl acetate / butanol mixture was concentrated under reduced pressure, and the obtained ethyl acetate / butanol mixture extract had a mass of 13.5 g. Using the above water layer and the ethyl acetate / butanol mixed solution extract, the insulin resistance improving effect was evaluated by the insulin tolerance test shown in Example 3 described later, and it was confirmed in the ethyl a...

preparation example 2

[0123] The mesophyll (transparent gel part) of Aloe vera is heated and dried and pulverized, and 60ml of 60%, 80% or 100% ethanol is added to 0.3g of dried Aloe vera powder, and then heated under reflux at 60°C for 1 Hour. The extract was centrifuged at 1500 rpm for 20 minutes, the supernatant was concentrated under reduced pressure, and ethanol was completely removed to obtain a crude extract. The dry masses of the crude extracts obtained by extraction with 60%, 80% and 100% ethanol were 65 mg, 42 mg and 18 mg, respectively. It was confirmed by thin layer chromatography that these crude extracts contained 3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol.

preparation example 3

[0125] The mesophyll (transparent gel part) of Aloe vera was heat-dried and pulverized, and 60 ml of water was added to 0.3 g of dried Aloe vera powder, followed by heating and reflux at 95° C. for 5 hours. The extract was centrifuged at 1500 rpm for 20 minutes, and the supernatant was freeze-dried to obtain 75 mg of crude extract. It was confirmed by thin layer chromatography that these crude extracts contained 3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol.

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PUM

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Abstract

Disclosed is a pharmaceutical or beverage / food which can inhibit the production of an adipocytokine, particularly an adipocytokine that can induce the resistance to insulin, to thereby prevent or ameliorate the occurrence of a morbid condition relating to insulin resistance. The pharmaceutical or beverage / food comprises, as an active ingredient, 3-O-beta-D-glucopyranosyl-4-methylergost-7-en-3-ol,or an extract of a plant belonging to the family Liliaceae with an organic solvent or hot water or a squeezed solution of the plant or a fractionated product of the extract or squeezed solution whichcontains the compound.

Description

technical field [0001] The present invention relates to an insulin resistance improving agent containing 3-O-β-D-glucopyranosyl-4-methylergost-7-en-3-ol as an active ingredient, and a food or drink containing the improving agent. More specifically, factors involved in regulating the onset and severity of insulin resistance-related pathologies - free fatty acids, plasminogen activator inhibitor, tumor necrosis factor, monocyte chemoattractant protein-1, resistin Insulin resistance improving agent with the effect of producing adipocytokines, etc., and beverages and foods containing the improving agent. Background technique [0002] Insulin is one of the hormones produced by β cells in the islets of the pancreas (Islets of Langer's), and is used not only in glucose metabolism but also in fat via insulin receptors present in insulin target tissues such as skeletal muscle, liver, and fat. It also plays a role in metabolism and protein metabolism, and plays an important role in m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A23L1/30A61K36/896A61P3/04A61P3/06A61P3/10A61P9/12C07J9/00C07J17/00
CPCA61K31/704A61K36/896A23L2/52A23L1/3002A23L33/105A61P3/04A61P3/06A61P3/08A61P3/10A61P5/50A61P9/00A61P9/10A61P9/12A61P13/12A61P27/02C07J7/00
Inventor 田中美顺三泽江里子
Owner MORINAGA MILK IND CO LTD
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