Preparing method of compound collagen hemostatic material

Abstract

A preparing method of complex collagen hemostatic material belongs to the field of medical biomaterials. Hemostatic time is the standard for evaluating the quality of hemostatic materials; therefore, increasing the hemostatic properties of collagen material is still the key point of research and development. The invention firstly uses aldehydes to do chemical modification to soluble collagen, thus making into modified collagen web, and as the water affinity of the collagen is improved, the hemostatic property is improved. Furthermore, Chinese herbal medicine that can catalyze soluble fibrin in plasma into dissoluble fibrin is chosen to prepare into solution; the wed of the modified collagen is immerged in the medical solution completely. Owning to the molecular bond of modified collagen and the herbal, the diffusion and permeability, drug molecules can enter the three-screw structure of the collagen, thus forming the complex collagen hemostatic material. The material has obvious improvement on the basis of modification in both normal coagulation and abnormal coagulation, and the hemostatic time is 45 seconds to 60 seconds, and the material is superior to medical collagen hemostatic materials in board and to similar medical collagen hemostatic materials in Japan.

Description

technical field [0001] The invention modifies the collagen, and the modified collagen is made into a composite material with Chinese herbal medicine, shortens the hemostatic time of the composite material, and is applicable to the hemostatic material category in the field of medical biological materials. Background technique [0002] Bleeding brings many risks and hazards to surgical operations and human life, and seeking ideal and effective hemostatic agents has always been a research hotspot at home and abroad. Following the war in Afghanistan, Iraq and anti-terrorism in the world, the U.S. military has developed a rapid hemostatic agent (the hemostasis time is 30s). The performance of the material puts forward higher requirements. With the continuous improvement of the level of medical technology, hemostatic materials and methods have been greatly developed. In recent years, many hemostatic agents have been developed at home and abroad, commonly used are gelatin sponge,...

AI Technical Summary

Problems solved by technology

In recent years, many hemostatic agents have been developed at home and abroad, commonly used are gelatin sponge, fibrin glue, oxidized cellulose, thrombin, etc. Compared with traditional hemostatic materials and methods such as gauze and ligation, the hemostatic effect is significantly better. But the speed is not very fast, and they also have certain disadvantages or side effects: gelatin may increase the infection rate of wounds, especially contaminated wounds, and its adhesion is poor and easy to fall off. If it is used for visceral hemostasis, it needs to be sutured and fixed. In addition, because its hemostatic effect depends on the participation of coagulation factors in the body, its hemostatic effect is often unsatisfactory when accompanied by coagulation mechanism disorders; fibrin glue is a blood product, and there is a risk of spreading blood-borne infectious diseases such as hepatitis or AIDS , and should not be directly injected into blood vessels during use to prevent thrombosis or allergic reactions. In addition, the hemostatic effect on arterial and large venous bleeding is not good; the acidity of oxidized cellulose may cause nerve fiber degeneration, and it has a strong If it is damp, it will affect its hemostatic effect; although thrombin can obviously promote the attachment and aggregation of platelets, it is more expensive; another effective hemostatic agent-collagen hemostatic agent does not have the above defects, and Compared with the above-mentioned ones, its hemostatic time is short, the effect is good, the side effect is small and it is more economical, it is an ideal hemostatic agent

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