Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chinese traditional medicine compounds for treating vifiligo and preparing method thereof

A substance and main drug technology, applied in the field of preparation of drug gels, can solve problems such as loss of activity, broken bottle leakage, precipitation, etc., to achieve the effect of reducing adverse reactions, reducing doses, and increasing accumulation

Inactive Publication Date: 2008-07-23
FUREN PHARMA GROUP
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In our practical application, we found that psoralen injection has high requirements on transportation conditions, and it is easy to freeze in winter. If no attention is paid, the phenomenon of broken bottle and leakage will often occur; The components psoralen and isopsoralen are susceptible to the interference of external factors in the production, storage and transportation, etc., which will deteriorate and lose their activity, and are prone to precipitation and discoloration, which will affect the use of patients; more importantly, The treatment of vitiligo requires a long course of medication, usually for several months, or even several years. The use of injections brings more inconvenience to patients, and some patients have various degrees of allergies after injection. reaction

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0027] Experimental example: Pharmacodynamic comparison between gel of the present invention and psoralen injection for treating vitiligo

[0028] In this study, animal models of vitiligo were selected, and the pharmacodynamics of the gel (low, medium and high doses) of the present invention and psoralen injection were compared. The results are shown in Tables 1 and 2.

[0029] 1. Experimental materials

[0030] 1.1 Animal guinea pig, weighing 200-250g, both male and female.

[0031] 1.2 Experimental drugs

[0032] Gel of the present invention: provided by Henan Furen Pharmaceutical Technology Development Co., Ltd.; psoralen injection (provided by Henan Furen Huaiqingtang Pharmaceutical Co., Ltd.).

[0033] 2. Methods and Results

[0034] 2.1 Replication of Vitiligo Animal Model

[0035] Take 60 black guinea pigs, cut off the hair of the black skin area on the back about 40cm 2 . Ten rats were randomly selected as the control group, and the remaining 50 rats were coated...

Embodiment 1

[0056] The gel agent of the present invention and its preparation method will be further described below with specific examples.

[0057] Component Weight (g)

[0058] Psoralen 500g

[0059] 95% ethanol 450ml

[0060] Carbomer 5g

[0061] Propylene glycol 2g

[0062] Ethylparaben 0.5g

[0063] Triethanolamine, water appropriate amount

[0064] Preparation method: first crush 500g psoraleae into coarse powder, use 95% ethanol as solvent, soak for 24 hours, then slowly percolate, collect percolation liquid, filter, recover ethanol under reduced pressure at 70°C, and concentrate to relative A thick paste with a density of 1.30-1.35 (55°C) is set aside; another gel matrix is ​​evenly sprinkled on the surface of an appropriate amount of purified water, swelled overnight, and propylene glycol, ethyl paraben are added under stirring, and triethanolamine is added to adjust the pH value to 6.5 to 7.5 to make a gel base; then add psoralen thick paste to the co-solvent, stir evenly...

Embodiment 2

[0066] Component Weight (g)

[0067] Psoralen 350g

[0068] 80% ethanol 350ml

[0069] Carbomer 15g

[0070] Propylene glycol 10g

[0071] Ethylparaben 1g

[0072] Triethanolamine, water appropriate amount

[0073] Preparation method: first crush 350g psoraleae into coarse powder, use 80% ethanol as solvent, soak for 30 hours, then slowly percolate, collect percolation liquid, filter, recover ethanol under reduced pressure at 70°C, and concentrate to relative A thick paste with a density of 1.30-1.35 (55°C) is set aside; another gel matrix is ​​evenly sprinkled on the surface of an appropriate amount of purified water, swelled overnight, and propylene glycol, ethyl paraben are added under stirring, and triethanolamine is added to adjust the pH value to 6.5 to 7.5 to make a gel base; then add psoralen thick paste to the co-solvent, stir evenly, add water to the prepared gel base, add water to 1000g, stir evenly, let stand, remove air bubbles, pack separately , that is.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a drug combination, in particular to a traditional Chinese medicine combination used for treating vitiligo, pertaining to the traditional Chinese medicine field. The traditional Chinese medicine combination is mainly made from psoralen as the raw material. And through improving the psoralen injection formulation, the disadvantages existing in the prior art are overcome. An external gel is also provided by the invention, which has a simple preparation technology, novel formulation, high biological utilization and stable property and convenient use; the effect can be fast and good when the invention is directly used in the surface of affected skin; besides, drug accumulation on affected skin can be enhanced, thereby, the dosage can be reduced and adverse reaction caused by whole body absorption can be decreased.

Description

technical field [0001] The invention relates to a pharmaceutical composition with the traditional Chinese medicine Psoraleae as the main medicine and a preparation method of the pharmaceutical gel, belonging to the field of traditional Chinese medicines. Background technique [0002] Vitiligo (vitiligo) is called "Vitiligo", "White Mottled" and "White Spot" in traditional Chinese medicine. It is an acquired depigmentation disease, and the incidence rate in China is as high as 0.1% to 2%. It mostly occurs in adolescents aged 8 to 30. According to foreign reports, 30% of patients have family genetic history, and the incidence rate has been increasing year by year in recent years. [0003] Vitiligo is clinically manifested as depigmented spots with well-defined borders and is difficult to treat. Years of clinical research have shown that the body's immune function in patients with vitiligo is abnormal, especially the cellular immune function is low. Traditional Chinese medicin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/487A61K9/00A61K47/36A61K47/38A61K47/42A61P17/00A61K131/00A61K47/32
Inventor 朱成功
Owner FUREN PHARMA GROUP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com