Injection type artificial crystalline lens material containing reversible disulfide bond and preparation method

An intraocular lens, disulfide bond technology, applied in intraocular lenses, prostheses, eye implants, etc., can solve the problems of low refractive index and poor AAM biocompatibility, and achieve high light transmittance and biocompatibility Good performance, the effect of solving the glare problem

Inactive Publication Date: 2008-07-09
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to prepare an intraocular lens material with a high refractive index and good biocompatibility for the defects that the existing injectable intraocular lens materials have a relatively low refractive index and relatively poor biocompatibility of AAM.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] The preparation of embodiment 1 ANSS gel

[0010] AAm, NVP and BAC were dissolved in 20-30% ethanol aqueous solution, stirred at room temperature, after the monomers were completely dissolved, TEMED and APS were added to polymerize the monomers, and the polymerization reaction continued at room temperature for 24 hours. Soak the hydrogel generated after polymerization in 200 ml of deionized water, replace the deionized water every 3 hours for the first 12 hours, and replace the deionized water every 12 hours after soaking for 5-8 days. The water that has passed is detected by a UV-Vis spectrophotometer, and the content of unreacted monomers and photoinitiators remaining in the gel is analyzed. The monomer ratio and results of the reaction are listed in Table 1. Unreacted monomers and photoinitiators inside the gel are toxic to eye cells, so purification of the gel is one of the key steps in the preparation of biocompatible intraocular lenses. It can be seen from Table...

Embodiment 2

[0014] The preparation of embodiment 2ANSH gel

[0015] Cut the ANSS sample into small pieces, and then add a certain amount of DTT. After the gel is completely transformed into a liquid, adjust the pH of the solution, and continue stirring at room temperature to convert the disulfide bonds in the solution into thiol groups. Adjust the solution The volume is 50 ml, and then precipitated in an excess of organic solvent, filtered, and the precipitated ANSH sample is collected. The ANSH yield was calculated by equation (1), and the thiol content was determined by the Ellman method. The reaction conditions and results are shown in Table 2. It can be seen from Table 2 that with the increase of the monomer concentration, the yield of the sample increases gradually. The increase of the initiator dose and the decrease of the amount of crosslinker BAC are not conducive to the improvement of the yield of ANSH. The ANSH yield decreased with the increase of NVP content in the sample. T...

Embodiment 3

[0018] The preparation of embodiment 3RANSS gel

[0019] ANSH was prepared into aqueous solutions of different concentrations, and then a certain amount of DTDP was added to cross-link the thiols in ANSH to form disulfide bonds, and the aqueous solution formed a gel. The time of gel formation was measured by the test tube inversion method, the light transmittance of the gel was measured with a UV-visible spectrophotometer, and the refractive index of the gel was measured with an Abbe refractometer. The experimental conditions and results are listed in Table 3. It can be seen from Table 3 that as the amount of DTDP added increases, the gelation time is significantly shortened from tens to hundreds of minutes to several minutes. It can be seen that the gelation time can be effectively adjusted by adjusting the content of DTDP. The gelation time is convenient for selecting the appropriate polymerization gelation time. At the same time, it can be seen that the gelation time of A...

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Abstract

The invention relates to an injection artificial lens material with disulfide bond and a preparation method thereof, which belongs to the field of organic polymer materials, and is characterized in that N, N dipropionamide (BAC) with invertible disulfide bond is taken as cross linker and N-vinyl pyrrolidone (NVP) with high refractive index and good biocompatibility is taken as comonomer, which is obtained by polymerization with AAm. First, the BAC, the NVP and the AAm are polymerized in 25 percent of ethanol aqueous solution to form aquagel ANSS, and the obtained aquagel is soaked in water and purified; and then the disulfide bond in the aquagel is cut off by dithiothreitol (DTT), to form water soluble polymer ANSH with sulfhydryl group; after deposition and purification, the ANSH is dissolved in water, disulfide bond exchanger is added in, to re-oxidate the ANSH and form aquagel RANSS, so as to form the injection artificial lens. The material of the invention has good biocompatibility and high light transmission of visible light zone, is used in the injection artificial lens, can solve the glare problem, and personalize the artificial lens.

Description

technical field [0001] The invention belongs to the field of organic macromolecular materials, relates to artificial lens materials and a preparation method, and particularly relates to the preparation of injectable artificial lens materials by adopting the reversibility of disulfide bonds. Background technique [0002] Intraocular lens implantation is the most effective way to restore vision to cataract patients, and the invention of this technology has brought a leap forward in the field of ophthalmology. The world's first intraocular lens implantation was completed in November 1949 by British ophthalmologist Ridley. Since then, the research of intraocular lens has been developed rapidly. At present, foldable intraocular lens has been widely used and relieved the pain of many patients. The foldable intraocular lens is processed outside the body, and the elastic model of the material is relatively large, so it is difficult to achieve the ability to truly adjust myopia-hype...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61F2/16C08F226/10C08F220/56C08F8/00
Inventor 杨槐牛国光张红斌宋黎李发胜郑裕东
Owner UNIV OF SCI & TECH BEIJING
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