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New use of scyphiphora hydrophyllacea and its extract in preparing anti-liver-cancer medicine

An extract, anti-liver cancer technology, used in anti-tumor drugs, drug combinations, drug delivery and other directions, can solve problems such as no patent disclosure, and achieve the effects of less toxic side effects, control of cancer cell proliferation, and significant curative effects

Inactive Publication Date: 2008-05-28
INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There is no patent disclosure about the use of the vase tree and its extracts in the preparation of anti-liver cancer drugs according to the present invention.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 2.0 kg of dried flowers and trees in a bottle, extract with 10 times the amount of 95% ethanol for 3 times (5, 3, 3 days), recover ethanol under reduced pressure, concentrate and dry to obtain extract powder, add appropriate amount of starch to the extract powder, and mix well , granulation, drying, granulation, and filling into capsules to make 1000 capsules.

Embodiment 2

[0027] Take 10.0 kg of dried flowers and trees in a bottle, percolate with 9 times the amount of 90% ethanol, concentrate the percolation liquid under reduced pressure until there is no alcohol smell to obtain a concentrated solution, add an appropriate amount of water to dilute the concentrated solution, and use petroleum ether, ethyl acetate, n-butyl Alcohol was extracted 4 times respectively, and petroleum ether, ethyl acetate, and n-butanol extract were recovered under reduced pressure to obtain petroleum ether section extract A, ethyl acetate section extract B, and extract B was dried to obtain bottle flower extract B . Take 100g of flower and tree extract B in a bottle, add appropriate amount of auxiliary materials such as starch, mix evenly, granulate, dry, and press into 1000 tablets.

Embodiment 3

[0029] Take 5.0 kg of dried flowers and trees in a bottle, percolate with 8 times the amount of 80% ethanol, concentrate the percolation liquid under reduced pressure until there is no alcohol smell to obtain a concentrated solution, add an appropriate amount of water to dilute the concentrated solution, and use petroleum ether, ethyl acetate, n-butyl Alcohol was extracted 4 times respectively, and the ethyl acetate extract was recovered under reduced pressure to obtain the ethyl acetate section extract, and the ethyl acetate section extract was dried to obtain the bottle flower extract B; take 25g bottle flower extract B, add appropriate amount of water for injection Dissolve, according to the conventional water injection process, adjust the pH value, filter, potting, and sterilize to make 1000ml; or add an appropriate amount of additives such as mannitol, dissolve and stir well, filter, sub-package, and freeze-dry to make 500 bottles That's it.

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PUM

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Abstract

The invention relates to a new function of Scyphiphora hydrophyllacea Gaertn.f. and the extractive thereof in the preparation of anti-hepatoma agents, disclosing the extractive method of the effective anti-hepatoma part of the Scyphiphora hydrophyllacea Gaertn.f., which is extracted by ethanol, and leached by petroleum ether, ethyl acetate and normal butanol, thus obtaining different extractive parts. The experiments prove that the ethyl acetate part derived from the extraction has stronger treatment function for hepatic tumor. The invention provides a new function for Scyphiphora hydrophyllacea Gaertn.f.

Description

technical field [0001] The invention relates to a new medical application of medicinal plants, in particular to the application of vase tree and its extract in the preparation of antitumor drugs, and belongs to the field of traditional Chinese medicine and natural medicine. Background technique [0002] Mangroves refer to woody plant communities that are naturally distributed in the intertidal zone of tropical and subtropical coasts. Due to its special growth environment, mangrove plants contain novel structures and biologically active compounds, and some mangrove plants have high medicinal value, and have become one of the important resources for finding natural bioactive ingredients ("China Natural Medicines") , 2004, 2: 137; "China Marine Drugs", 2004, 23: 26). The mangrove plant Scyphiphora hydrophyllacea Gaertn.f. belongs to Rubiaceae (Rubiaceae) Scyphiphora, distributed from south to southeast Asia, south to the Caroline Islands, Australia and New Caledonia, In my cou...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/08A61K9/10A61K9/16A61K9/19A61K9/20A61K9/48A61P1/16A61P35/00A61K127/00A61K135/00
Inventor 戴好富曾艳波梅文莉
Owner INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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