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Intermediate compound of a liquid state traditional Chinese medicinal preparation and preparation method and application thereof

A technology of traditional Chinese medicine preparations and intermediates, applied in the field of traditional Chinese medicines, can solve the problems of increased environmental requirements, inconvenience of direct preparation, increased particle size and the like

Inactive Publication Date: 2008-05-28
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of preparation and storage, due to the large surface energy of the micropowder, there are van der Waals force, liquid bridge force, electrostatic force, etc. between the particles, and the number of surface charges increases, and the micropowder particles have a strong tendency to adsorb each other and agglomerate, which increases the particle size. It affects the effect of ultrafine pulverization; at the same time, due to the increase of the combined area of ​​the fine powder and the moisture in the air, it is easy to absorb moisture, the fluidity becomes poor, and the requirements for the environment are also correspondingly increased, which is extremely inconvenient for direct preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0145] Take leeches, wash them, dry them at low temperature, and crush them through a 50-mesh sieve; take 400-440 g of polyethylene glycol and 35 g of propylene glycol, and mix them to make a matrix. Minutes, the material is discharged to prepare an ultrafine mixture with a central particle diameter of less than 25 μm, which is directly used for pressing soft capsules.

Embodiment 2

[0147] Get leech, wash, dry at low temperature, pulverize through 50 mesh sieves; Get polyethylene glycol 400 345g, propylene glycol 30g, Tween 70g, mix, make matrix, add leech powder 125g, put in the vibrating micropowder machine, super Finely pulverize and mix for 60 minutes, and discharge to obtain an ultrafine mixture with a central particle diameter of less than 25 μm, which can be directly used for filling liquid hard capsules.

Embodiment 3

[0149] Take the leeches, wash them, dry them at low temperature, and crush them through a 20-mesh sieve; take 400 g of polyethylene glycol and 100 g of propylene glycol, and mix them to make a matrix. Minutes, the material is discharged, and a superfine mixture with a central particle diameter of less than 25 μm is obtained.

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PUM

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Abstract

The invention discloses an intermediate of a liquid Chinese medicine preparation, the preparation and the application thereof; the invention includes pulverization method of single leech ultrafine powder, in particular to a pulverization method for preparing leech ultrafine powder by wet-method ultrafine pulverization method. The method is that: leech medical material is ground through a traditional method, then added with any one or the compositions of a plurality of carbowax, propylene glycol, glycerol and tween, and then undergone ultrafine pulverization to obtain the preparation intermediate; the intermediate products can be prepared into required dosage forms. The method can improve pulverization efficiency and decrease raw material usage amount in the products.

Description

technical field [0001] The invention relates to an intermediate of a leech-containing single medicinal material preparation and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] 1. Research progress of leeches [0003] The effect of leech is to break blood, expel blood stasis, and eliminate symptoms. It can be used for lumps in the abdomen, blood stasis, amenorrhea, bruises, thrombocytosis, and cerebral hemorrhage. Leeches were first recorded in "Shen Nong's Materia Medica": "The main purpose is to drive away bad blood, blood stasis, moon closure, accumulation of broken blood, no children, and water passages." Salty and bitter, in order to remove blood accumulation, it is the medicine of the liver meridian blood, so it can dredge the liver meridian and gather blood." [0004] Leeches are highly specialized annelids. Currently, there are more than 300 species known in the world, and 62 species are distribut...

Claims

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Application Information

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IPC IPC(8): A61K35/62A61K9/14A61K9/107A61K9/48A61P3/06A61P7/02A61P9/00A61P15/00A61P17/00
Inventor 周小明刘国飞
Owner 北京凯瑞创新医药科技有限公司
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