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Quality detecting method of mountain green tea blood pressure reducing preparations

A quality inspection method and technology for camellia green tea, applied in the direction of testing pharmaceutical preparations, measuring devices, material inspection products, etc., can solve problems such as poor stability, poor reproducibility, poor separation of rutin peaks and adjacent impurity peaks, etc. problem, to achieve the effect of good spot separation, stable and accurate curative effect, stable and controllable quality

Active Publication Date: 2010-09-08
广西万寿堂药业有限公司
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AI Technical Summary

Problems solved by technology

In the TLC identification item in the existing mountain green tea preparation quality detection method, the spot separation is not very ideal, and the reproducibility is poor, and the TLC identification is a qualitative identification, which cannot fully reflect the internal quality of the product
Rutin, the main component of camellia green tea, can be determined by high performance liquid chromatography. However, after many experiments and investigations, it was found that the separation between the rutin peak and the adjacent impurity peaks was not good enough, and the separation degree and plate number could not meet the requirements of high performance liquid chromatography. , the stability is not good, the error is too large, and it cannot accurately reflect the intrinsic quality of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Mountain Green Tea Antihypertensive Capsules

[0015] [Preparation method] Get 3600g of mountain green tea, be ground into coarse powder, sieve, get 180g fine powder for subsequent use, remaining coarse powder according to the percolation method under flow extract and extract item (Chinese Pharmacopoeia 2005 edition one appendix 10) , using 70% ethanol as solvent, percolating after soaking for 18 hours, until the filtrate is light in color, the filtrate is decompressed to recover ethanol and concentrated to a thick paste, add the above fine powder, mix, dry, pulverize, add appropriate amount The talc powder is mixed evenly, packed into capsules, and made into 1000 capsules, and the product is obtained.

[0016] 【Identification】Take 3 capsules of this product, take out the contents, add 20ml of water, grind for a few minutes, transfer to a separatory funnel, add 20ml of ether, shake and extract, separate the ether solution, add 0.5g of activated carbon, shake for a few m...

Embodiment 2

[0020] Mountain Green Tea Antihypertensive Tablets

[0021] [Preparation method] Take 1800g of mountain green tea, crush it into coarse powder, sieve, take 90g of fine powder for later use, make a thick paste according to the preparation method of capsules, add fine powder and appropriate amount of starch, mix well, make granules, dry, and press Into 1000 tablets, coated, that is.

[0022] [Identification] Take 6 tablets of this product, remove the coating, add 40ml of water, grind for several minutes, transfer to a separatory funnel, add 40ml of ether, shake and extract, separate the ether solution, add 1g of activated carbon, shake for several minutes, filter , The filtrate was evaporated to dryness, and the residue was dissolved in 1ml of methanol, filtered, and the filtrate was used as the test solution. In addition, take 5 g of mountain green tea reference medicinal material, add 50 ml of 70% ethanol, and make a reference medicinal material solution according to the prep...

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Abstract

The present invention relates to a quality inspection method for Chinese patent medicines, in particular to a quality inspection method for capsules and tablets with camellia ethanol extract, proper fine camellia powder as ingredients, which modifies folium authentication for camellia medicine in prior arts and selects an optimal expansion system and visualization reagent to ensure better and clearer spot separation, enable field technicians in the market to be faster and more skilled to confirm authenticity of products. In addition, the method adds a method to measure content of quercetin aseffective ingredients of the preparation to provide reliable guarantee to make product quality stable and controllable and its curative effect stable and accurate.

Description

technical field [0001] The invention relates to a quality detection method of a Chinese patent medicine, in particular to a quality detection method of camellia tea antihypertensive preparation. Background technique [0002] The medicinal material of mountain green tea is the dried leaves of Ilex hainanensis Merr., a plant of the Ilex family, which was recorded in the 1990 edition of "Guangxi Standards of Chinese Medicinal Materials". [0003] The preparations currently on the market are Shanlvcha Jiangya Tablets, which are recorded in Volume 15 of the "Ministry of Health Drug Standards for Traditional Chinese Medicine Prescriptions". The function of clearing heat and detoxifying, calming the liver and suppressing yang. It is used to treat dizziness, tinnitus, headache, fullness of the head, upset and irritability, less sleepiness and more dreams, high blood pressure, and high blood lipids. In the TLC identification item in the existing mountain green tea preparation quali...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/00G01N30/02G01N30/90G01N33/15
Inventor 韦宏官黎德南杨桂芳
Owner 广西万寿堂药业有限公司
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