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Extractive of humulus plants, its use and pharmaceutical composition containing the extractive

A technology of extracts and compositions, which is applied in the field of traditional Chinese medicine preparations, can solve the problems of undiscovered application significance and value of Humulus japonicus extract, difficulty in processing, and difficulty in preservation, etc., and achieve rich plant resources of the genus Humulus genus, increase the content of effective substances, Ease of preservation and processing

Inactive Publication Date: 2008-02-27
王宝民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these two studies have done some research on the extraction of total flavonoids from Humulus japonicus, the optimal conditions are different, the results vary greatly, the quality is difficult to control, the product has poor physical properties, difficult to preserve, difficult to process, etc., more importantly, there is no Further separation and purification of the extract resulted in a lower content of total flavonoids in the active substance Humulus japonicus in the extract, and the specific application significance and value of the Humulus japonicus extract were not found in these studies

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Water Extracted Humulus officinalis Extract

[0029] Take the whole humulus herb (dried humulus or fresh humulus converted into dry humulus), grind it appropriately, add 12 times of water for the first extraction, and reflux extraction at 80°C for 1.5h (preferably), after filtering, add 8 times of water to the filter residue water, reflux extraction again for 1.0h, combine the secondary extracts, concentrate the extracts under reduced pressure to a crude drug concentration equivalent to 0.3g / ml, use ZTC1+1 natural clarifier, chitin or 101 fruit juice clarifier to remove impurities (preferably ZTC1+ 1 natural clarifying agent, dosage 5g / kg crude drug), filter and discard the precipitate, macroporous resin adsorption on the filtrate (macroporous resin column capacity and original medicinal material weight ratio is 1: 1.5), take a certain amount of pretreated weak polarity AB -8 resin, packed into a glass column with an inner diameter of 8 cm and a column height of 100 cm,...

Embodiment 2

[0031] Alcohol-extracted Humulus japonicus extract

[0032]Take the whole humulus herb (dry humulus or fresh humulus converted into dry humulus), crush it properly, add 12 times of 5%-90% lower alcohol for the first extraction, and reflux extraction at 75°C (preferably) for 1.5h, After filtering, add 8 times lower alcohol to the filter residue, reflux and extract again for 1.0 h, combine the secondary extracts, concentrate the extracts under reduced pressure, and recover the lower alcohols, adjust the concentration of the extracts to be equivalent to the concentration of crude drugs 0.3g / ml, use ZTC1+1 natural clarifier, chitin or 101 fruit juice clarifier for impurity removal (preferably ZTC1+1 natural clarifier, dosage 5g / kg crude drug), filter and discard the precipitate, macroporous resin adsorption on the filtrate (macroporous resin column capacity is the same as the original The medicinal material weight ratio is 1:1.5), take a certain amount of pretreated D-101 resin, p...

Embodiment 3

[0034] tablet

[0035] Preparation method: Take 25 g of the water-extracted Humulus japonicus extract obtained in Example 1, add 5 g of compressible starch and 5 g of dextrin, mix well, use 50% ethanol wet method to granulate, cool to below 60 ° C for drying, and prepare granules, add 0.5g of talcum powder, mix well, and press into 100 tablets, the content of water-extracted Humulus japonicus extract is 0.25g / tablet.

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PUM

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Abstract

The invention discloses an extract of humulus scandens merr to be full-grass of Moraceae Humulus plant, which comprises the following steps: refluxing and extracting Humulus plant through solvent water or 5-90% low-grade alcohol at 50-90 deg. c; adsorbing through large-hole adsorbing resin; eluting; drying; obtaining the extract with total flavone content at 35-80%. The invention also provides an application as health product and drug composition of Humulus plant to release skin pruritus and allergic phenomenon.

Description

technical field [0001] The invention relates to a total flavonoid extract of plants of the genus Humulus, its use and a pharmaceutical composition containing the extract, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] Humulus is derived from the genus Moraceae, an angiosperm plant, and is the whole plant of Humulus scandens (Lour.) Merr. (English name of Humulus: Japanese Hop Herb, Latin name of Humulus: Herba Humuli Scandentis). [0003] The Humulus genus generally includes two species: Humulus and Humulus. [0004] Humulus (also known as Lalavine, Lalavine, Wugualong, Cutrenvine, Lalayang, Guogoulong) is distributed in all provinces except Xinjiang and Qinghai, especially in Northeast my country, North China, Central South and Southwest China , Shaanxi, and Gansu areas are mostly. [0005] Hubu H.lupulus L. originated from Europe and has been recorded in past herbal medicines. Its original name can be found in the Chines...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P17/00A61P17/04A61P37/08
Inventor 王宝民
Owner 王宝民
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